One-Stop Solution for Nucleic Acid Drug Formulations

From standard gene monomer feedstocks to intricate mini-nucleic acids and mRNAs, CD Formulation provides outstanding quality and value to our customers. We provide our customers with a comprehensive one-stop solution for nucleic acid drug formulation, encompassing a full range of services from sequence design and synthesis to optimization and delivery systems.

About Nucleic Acid Drugs

Nucleic acid drugs are therapeutics that regulate gene expression at the post-transcriptional and pre-translational stages, acting upstream of protein synthesis. Compared to traditional small molecule drugs and antibody therapies, nucleic acid drugs offer several advantages, including ease of design, shorter development cycles, high target specificity, broad therapeutic applications, and prolonged efficacy.

Fig.1 Aptamer-based DDSs. (Tan X, et al., 2020)

Types of Nucleic acid drugs

• mRNA
• Antisense Oligonucleotides (ASOs)
• Small Interfering RNA (siRNA)
• Aptamer
• Small activating RNA (saRNA)
• Single Guide RNA (sgRNA)
• MicroRNA (miRNA)
• Circular RNA (circRNA)
• Ribozyme
• DNAzyme
• ...

One-Stop Solution for Nucleic Acid Drug Formulations

CD Formulation offers comprehensive solutions for nucleic acid formulations, focusing on delivering end-to-end services from project design to production. We ensure the efficiency, safety, and stability of nucleic acid drugs while providing robust technical support for both research and industrialization. By partnering with us, you can significantly expedite the development and commercialization of nucleic acid drugs.

Fig.2 Solutions for nucleic acid formulations. (CD Formulation)

Nucleic Acid Design

Nucleic acid design encompasses the creation and optimization of nucleic acid sequences from the ground up to enhance their potency and specificity. This process includes designing oligonucleotide sequences that bind selectively to the target RNA or DNA, predicting secondary structures, and minimizing the formation of unintended secondary structures and potential off-target effects.

Custom Synthesis of Nucleic Acids

Based on the advanced nucleic acid synthesis platforms we provide, we can guarantee high purity, high yield, and superior quality of nucleic acid products. The synthesized nucleic acids undergo a rigorous purification process, which includes high-performance liquid chromatography (HPLC) and mass spectrometry analysis, to ensure the purity and consistency of the final products.

Nucleic Acid Optimization

Nucleic acid optimization involves the modification and transformation of initially synthesized oligonucleotides to enhance their stability, biological activity, and in vivo safety. Common optimization techniques include chemical modifications of nucleotides (e.g., phosphate bond modification, sugar ring modification), nucleic acid lock modifications, and 2'-O-methyl modifications, among others.

Drug Delivery System Development

According to the characteristics of the drug, appropriate delivery carriers (e.g., lipid nanoparticles, polymer nanoparticles, viral vectors, etc.) are selected. These systems can protect nucleic acid molecules, enhance their stability in vivo, and facilitate their entry into target cells by traversing cell membranes. Additionally, advanced delivery systems enable targeted delivery, which increases the accumulation of nucleic acid drugs in specific tissues or cells through the modification of specific targeting molecules.

Nucleic Acid Formulation Development

According to the characteristics of the drug, appropriate formulation types (e.g., liquid formulations, lyophilized powder injections, etc.) are developed to enhance the stability, solubility, and bioavailability of the drug. The preparation process necessitates the strict implementation of a quality control system to ensure the safety, consistency, and efficacy of the formulation.

Our Capabilities of Technology

Our core technologies for nucleic acid drugs encompass sequence design, synthesis, formulation development, and delivery technologies.

Our Highlights of One-Stop Solution for Nucleic Acid Drug Formulations

• Comprehensive Support Throughout the Entire Process - Covering the entire process from design to preparation and delivery, we ensure professionalism and efficiency at every stage.
• Customization - We offer personalized solutions tailored to our customers' specific needs, including sequence design, modification, and optimization.
• High Efficiency and Precision - With advanced synthesis and optimization technologies, we ensure high efficiency and precision in nucleic acid drug development.
• Strict Quality Control - Strict quality control at every stage guarantees the high quality and consistency of the final product.
• Multiple Delivery Options - Various delivery system options are available based on the characteristics of the drug to ensure efficient and safe delivery to the target.

Publication Data

Relying on our robust technology platform and professional team, CD Formulation is dedicated to providing customers with efficient and reliable nucleic acid drug formulation solutions. We focus not only on precise operations and high-quality standards at every stage of the process but also place special emphasis on the critical steps of process validation and scale-up production to ensure the safety and efficacy of our products. Contact us to help advance your nucleic acid drug development and production.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.