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Solid Dispersion Preparation Technology for Nucleic Acid Formulations

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Based on years of solid dispersion preparation experience and a professional technical team, CD Formulation offers efficient and customized solid dispersion preparation services for nucleic acid drug development. By considering the unique characteristics of various nucleic acid drugs, we can choose the suitable carrier material and preparation process to create nucleic acid formulations with outstanding performance.

Advantages of Solid Dispersion Technology for Nucleic Acid Formulations

Solid dispersions, as preparation intermediates, can be transformed into various dosage forms based on specific requirements through the addition of suitable excipients and the implementation of an appropriate preparation process. By altering the dosage form, the drug's dispersion state can be modified, offering a distinct advantage in enhancing the bioavailability of challenging-to-solve drugs.

Fig.1 Advantages of solid dispersion technology. (CD Formulation)

Carrier Materials for Solid Dispersion

CD Formulation offers a comprehensive product line of solid dispersion carriers and can provide customized solid dispersion technology development services to meet a wide variety of application needs.

Carrier Materials	Descriptions	Examples
Water-soluble Carrier Materials	Water-soluble carriers can accelerate the dissolution rate of the drug, improve the solubility of the drug, and effectively enhance the bioavailability of the drug. Therefore, they are commonly used in the production of rapid-release solid dispersions.	Commonly used materials include PEG, PVP, poloxamer, chitosan, carbomer, urea, citric acid, succinic acid, and mannitol.
Insoluble Carrier Materials	Water-insoluble or fat-soluble carriers are predominantly utilized in the production of slow (controlled) release solid dispersions in actual manufacturing processes.	Commonly used water-insoluble carriers include ethyl cellulose, polyacrylic acid resin containing quaternary ammonium groups, cholesterol, sterol, and silica.
Enteric Soluble Carrier Materials	Enteric solid dispersion involves using enteric-soluble materials as a carrier and preparing solid dispersions located in the intestinal tract to dissolve and release drugs.	Commonly used carriers include cellulose and polyacrylic acid resins, such as hydroxypropyl methyl cellulose phthalate, cellulose acetate phthalate, carboxymethyl ethyl cellulose and so on.

Characterization of Solid Dispersions

Physical Structure Characterization

Scanning Electron Microscopy
Surface Area Analysis
Surface Characterization
Dynamic Vapor Sorption
Reverse Phase Gas Chromatography
Atomic Force Microscopy
Raman Microscopy

Stability Studies

Humidity Studies
DSC (Tg, temperature of recrystallization)
Dynamic Vapor Sorption
Saturation Solubility Studies

Drug Carrier Interactions

Infrared Spectroscopy
Raman spectroscopy
Solid State Nuclear Magnetic Resonance

Fig.2 Characterization methods for solid dispersions Fig.2 Characterization of solid dispersions. (CD Formulation)

Highlights of Solid Dispersion Technology for Nucleic Acid Formulations

Solid dispersion technology can be used to prepare a variety of dosage forms, such as tablets, capsules, and orally dissolved films, to meet various clinical applications and patient requirements.
Solid dispersion technology service platforms are typically equipped with advanced quality control and analytical instruments, such as DSC (Differential Scanning Calorimeter), XRD (X-ray Diffractometer), FTIR (Fourier Transform Infrared Spectroscopy), SEM (Scanning Electron Microscope), etc., to ensure product quality and consistency.
Solid dispersions can enhance the physical and chemical stability of drugs. For example, they can improve the stability of a drug during storage by preventing crystalline transformation or reducing degradation.

Custom Nucleic Acid Formulation Development Services

Whether it is to improve drug solubility and bioavailability or to enhance the stability and targeting of biomolecules, CD Formulation can offer customized solutions for high-performance solid dispersions.

Oral Nucleic Acid Formulation Development

Solid dispersion technology can help enhance the solubility and stability of nucleic acid drugs, thereby increasing their bioavailability.

Ophthalmic Nucleic Acid Formulation Development

Solid dispersion technology can be utilized to create carriers for extended drug release, thus improving the effectiveness of ophthalmic nucleic acid medications.

Nasal Nucleic Acid Formulation Development

Solid dispersion technology can enhance the solubility and adhesion of nucleic acid drugs, thereby boosting the efficiency of transnasal drug delivery.

Transdermal Nucleic Acid Formulation Development

Solid dispersion technology offers the opportunity to improve the transdermal absorption of nucleic acid drugs by combining them with suitable transdermal absorption enhancers and carrier systems.

Publication Data

Technology: Preparation of oral dispersible tablets using solid dispersion technology

Journal: Beni-Suef University Journal of Basic and Applied Sciences

IF: 2.5

Published: 2017

Results:

The article highlights the advances in the methods of manufacturing orally disintegrating tablets and the various state-of-the-art technologies involved in the development process. Solid dispersion technology is one of the new technologies for manufacturing orally disintegrating tablets. Solid dispersion is basically a drug polymer two-component system.

Fig.3 Preparation of oral dispersible tablets using solid dispersion technology Fig. 3 Classification of solid dispersion. (Nikam V K, et al., 2020)

CD Formulation's solid dispersion technology effectively overcomes the challenges of poor solubility and susceptibility to degradation encountered in the preparation and storage of nucleic acid drugs by uniformly dispersing them in a solid matrix. Contact us for a solution to your nucleic acid dosage form development.

References

Nikam V K, Shete S K, Khapare J P. Most promising solid dispersion technique of oral dispersible tablet. Beni-Suef univ. j. basic appl. sci. 2020, 9: 1-16.

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STEP 3

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