The primary goal of modern drug discovery is to screen, identify, and prepare effective drug targets. Our nucleic acid drug target screening platform can systematically discover disease-related potential targets from massive biological data. Through high-throughput biological validation, quantitative analysis, and mechanism of action studies, CD Formulation can identify the most valuable nucleic acid drug targets for development. Additionally, we can integrate this platform with Next-Generation Sequencing (NGS) and data analysis, which is crucial for identifying the appropriate drug targets and developing new drugs, particularly in the field of cancer therapeutics.
Our nucleic acid drug target screening platform is an integrated system for target discovery and validation. It combines robust bioinformatics analysis, high-throughput biological validation, and in-depth mechanism of action research capabilities. Our interdisciplinary team of experts provides technical support for the rapid development of nucleic acid drugs.
Fig.1 Advantages of target screening platform for nucleic acid drugs. (CD Formulation)
CD Formulation's nucleic acid drug target screening platform plays a key role in different disease areas, providing efficient and comprehensive technical support for target discovery and validation of nucleic acid drugs. Our capabilities include the following:
Utilizing our platform's biological tools and data analysis systems, we can identify targets with disease relevance, modulability and reliability.
Utilizing our platform's high-throughput screening technologies and analytical methods, we can deeply explore the impact of target regulation on cells or biological systems.
Integrate multiple levels of data and systematically evaluate and screen to identify the most promising target candidates.
Using optimized targets as breakthroughs, systematically evaluate the regulatory effects of nucleic acid drug molecules on targets.
Relying on professional analytical testing methods, we can deeply explore the regulatory mechanisms of nucleic acid drug candidates on targets.
CD Formulation's target screening platform provides a comprehensive and efficient solution for target identification and validation in nucleic acid drug development. At the core of our target screening platform are two complementary approaches:
We utilize advanced bioinformatics algorithms and in-lab modeling to perform a comprehensive analysis of genomic, transcriptomic and proteomic data to identify the most promising targets. This includes evaluating factors such as target expression patterns, disease relevance, druggability, and potential for modulation through nucleic acid therapy.
Our platform also employs a robust set of experimental techniques to validate identified targets. This includes cell-based assays, high-throughput screening, and targeted functional studies to assess the biological impact of target modulation and to confirm their viability as drug candidates.
CD Formulation offers professional nucleic acid drug target screening services to assist customers in promptly identifying potential biomarkers and targets associated with the target disease. Leveraging the bioinformatics analysis results from the platform, we can tailor nucleic acid sequences and offer additional experimental validation and optimization support to aid customers in developing targeted nucleic acid drugs.
Technology: Drug development utilizing target screening platforms
Journal: Pharmaceutica Analytica Acta
IF: 14.5
Published: 2015
Results:
The main applications of zebrafish in drug research, drug discovery and development are target screening, target identification, target validation and drug toxicity studies. Recently, zebrafish has become a model animal for certain human diseases. Zebrafish has many properties for toxicology studies and high-throughput screening. Perhaps surprisingly, zebrafish have disease-causing genes similar to humans. Zebrafish is a non-mammal and it is easier to test the toxicity of drugs and their potential therapeutic activity on targets than mammals. Zebrafish embryos have become an important vertebrate model for assessing drug effects. Zebrafish embryos have unique properties, including ease of maintenance and drug administration, short reproductive cycles, high transparency, and visual assessment of developing cells and organs. Results can be obtained quickly and at a low cost using zebrafish.
Fig. 2 Using an in vivo screening platform earlier in the discovery process. (Bhusnure O G, et al., 2015)
CD Formulation's nucleic acid drug target screening platform brings together a team of experts from bioinformatics, molecular biology, cell biology, and other disciplines, forming an efficient interdisciplinary collaborative mechanism that enhances the scientific rigor and relevance of target screening. Contact us for solutions to expedite nucleic acid drug development.
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