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Target Screening Platform for Nucleic Acid Drugs

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The primary goal of modern drug discovery is to screen, identify, and prepare effective drug targets. Our nucleic acid drug target screening platform can systematically discover disease-related potential targets from massive biological data. Through high-throughput biological validation, quantitative analysis, and mechanism of action studies, CD Formulation can identify the most valuable nucleic acid drug targets for development. Additionally, we can integrate this platform with Next-Generation Sequencing (NGS) and data analysis, which is crucial for identifying the appropriate drug targets and developing new drugs, particularly in the field of cancer therapeutics.

Advantages of Our Nucleic Acid Drug Target Screening Platform

Our nucleic acid drug target screening platform is an integrated system for target discovery and validation. It combines robust bioinformatics analysis, high-throughput biological validation, and in-depth mechanism of action research capabilities. Our interdisciplinary team of experts provides technical support for the rapid development of nucleic acid drugs.

Fig.1 Advantages of target screening platforms.Fig.1 Advantages of target screening platform for nucleic acid drugs. (CD Formulation)

Application of Nucleic Acid Drug Target Screening Platform

CD Formulation's nucleic acid drug target screening platform plays a key role in different disease areas, providing efficient and comprehensive technical support for target discovery and validation of nucleic acid drugs. Our capabilities include the following:

Target Discovery

Utilizing our platform's biological tools and data analysis systems, we can identify targets with disease relevance, modulability and reliability.

Target Validation

Utilizing our platform's high-throughput screening technologies and analytical methods, we can deeply explore the impact of target regulation on cells or biological systems.

Target Optimization

Integrate multiple levels of data and systematically evaluate and screen to identify the most promising target candidates.

Drug Candidate Screening

Using optimized targets as breakthroughs, systematically evaluate the regulatory effects of nucleic acid drug molecules on targets.

Mechanism Research

Relying on professional analytical testing methods, we can deeply explore the regulatory mechanisms of nucleic acid drug candidates on targets.

Our Target Screening Platform Types

CD Formulation's target screening platform provides a comprehensive and efficient solution for target identification and validation in nucleic acid drug development. At the core of our target screening platform are two complementary approaches:

Computational Target Screening

We utilize advanced bioinformatics algorithms and in-lab modeling to perform a comprehensive analysis of genomic, transcriptomic and proteomic data to identify the most promising targets. This includes evaluating factors such as target expression patterns, disease relevance, druggability, and potential for modulation through nucleic acid therapy.

Experimental Target Validation

Our platform also employs a robust set of experimental techniques to validate identified targets. This includes cell-based assays, high-throughput screening, and targeted functional studies to assess the biological impact of target modulation and to confirm their viability as drug candidates.

Highlights of Our Nucleic Acid Drug Target Screening Platform

  • The platform integrates bioinformatics analysis, high-throughput experimental screening and mechanism of action research, providing customers with a full range of services from target discovery to action verification.
  • The platform is equipped with a new generation of gene synthesis technology, which can quickly and efficiently prepare various nucleic acid sequences and provide strong technical support for subsequent experiments.
  • The platform is equipped with a variety of high-throughput screening technologies, including cell model-based functional evaluation, enzyme activity-based activity detection, etc., which can rapidly evaluate a large number of candidate targets.
  • Experienced bioinformatics analysis team with strong technical support conducts in-depth analysis of NGS data to accurately screen target candidate genes.

Custom Nucleic Acid Drug Development Services

CD Formulation offers professional nucleic acid drug target screening services to assist customers in promptly identifying potential biomarkers and targets associated with the target disease. Leveraging the bioinformatics analysis results from the platform, we can tailor nucleic acid sequences and offer additional experimental validation and optimization support to aid customers in developing targeted nucleic acid drugs.

Custom Small Nucleic Acid Synthesis

The nucleic acid drug target screening platform can rapidly identify potential targets related to target diseases through bioinformatics analysis, providing valuable target information for customized mini-nucleic acid drug design.

Custom mRNA Synthesis

Based on the screening results, mRNA drugs with specific sequences and structures can be customized through in vitro and in vivo experiments for the treatment of relevant diseases.

Publication Data

Technology: Drug development utilizing target screening platforms

Journal: Pharmaceutica Analytica Acta

IF: 14.5

Published: 2015

Results:

The main applications of zebrafish in drug research, drug discovery and development are target screening, target identification, target validation and drug toxicity studies. Recently, zebrafish has become a model animal for certain human diseases. Zebrafish has many properties for toxicology studies and high-throughput screening. Perhaps surprisingly, zebrafish have disease-causing genes similar to humans. Zebrafish is a non-mammal and it is easier to test the toxicity of drugs and their potential therapeutic activity on targets than mammals. Zebrafish embryos have become an important vertebrate model for assessing drug effects. Zebrafish embryos have unique properties, including ease of maintenance and drug administration, short reproductive cycles, high transparency, and visual assessment of developing cells and organs. Results can be obtained quickly and at a low cost using zebrafish.

Fig. 2 Use of screening platforms for drug development.Fig. 2 Using an in vivo screening platform earlier in the discovery process. (Bhusnure O G, et al., 2015)

CD Formulation's nucleic acid drug target screening platform brings together a team of experts from bioinformatics, molecular biology, cell biology, and other disciplines, forming an efficient interdisciplinary collaborative mechanism that enhances the scientific rigor and relevance of target screening. Contact us for solutions to expedite nucleic acid drug development.

References

  1. Bhusnure O G, Mane J M, Gholve S B, et al. Drug target screening and its validation by zebrafish as a novel tool. Pharm. Anal. Acta, 2015, 6(426): 10.4172.
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