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Nucleic Acid Formulation Preparation Technology

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CD Formulation has an experienced team in the field of nucleic acid formulation technology and has built a formulation preparation technology platform. We are well-versed in developing formulation technologies for various dosage forms, including oral, injectable, and transdermal formulations.

Advantages of Nucleic Acid Formulation Technology

Nucleic acid formulation preparation technology involves multi-step processes for the synthesis, modification, and delivery of small nucleic acids (such as siRNA, mRNA, and antisense oligonucleotides). The background of formulation preparation technology includes a combination of molecular biology, chemical synthesis, and nanotechnology aimed at disease intervention and treatment through precise gene regulation and therapeutics. Scientific and effective design and optimization of these nucleic acid drugs can not only improve their biological activity and stability but also enhance their in vivo stability and delivery efficiency, thus enhancing the effectiveness of clinical applications.

Technological diversity
High stability and efficient delivery
Flexible customization services
Innovative technology platform

Fig.1 Systems for the preparation of nucleic acid drugs. Fig.1 Advantages of nucleic acid formulation technology. (CD Formulation)

Our Capabilities for Nucleic Acid Formulations

Tablet, capsule and pediatric formulation development
Stability registration batches
Stability assessment
Process optimization and validation
Scale-up to commercial production
Control of critical steps
Batch production

Means of Characterizing Nucleic Acid Formulations

Particle Size Analyzer
High-Performance Liquid Chromatography (HPLC)
Capillary Electrophoresis
Mass Spectrometer
UV-Vis Spectrophotometer
Circular Dichroism (CD)

Types of Nucleic Acid Formulation Technology

CD Formulation is committed to providing cutting-edge nucleic acid formulation technologies to our global customers. Our technology platform encompasses solid dispersion preparation, hot melt extrusion, drug nanocrystals, coating, 3D printing, and microfluidics. These technologies are tailored to improve the stability, effectiveness, and patient adherence of nucleic acid drugs.

Items	Descriptions	Applications
Solid Dispersion Preparation Technology	Uniformly dispersing nucleic acid drugs in solid carriers can enhance the solubility and stability of the drugs.	It is suitable for oral and topical administration, improving the bioavailability of the drug.
Hot Melt Extrusion Technology	Utilizing hot melt extrusion to mix nucleic acid drugs with polymer carriers to form homogeneous solid formulations.	It is used for the preparation of oral and controlled-release formulations to enhance the release characteristics of the drug.
Drug Nanocrystal Technology	Nucleic acid drugs are processed into nanoscale particles using nanocrystal technology to enhance the solubility and bioavailability of the drugs.	It is suitable for intravenous injection and local drug delivery to enhance the effective concentration of the drug.
Coating Technology	Multi-layer coating technology is used to protect nucleic acid drugs and enhance their stability and targeting.	It is used for oral and local administration to prevent drug degradation in the gastrointestinal tract.
3D Printing Technology	Using 3D printing technology to precisely control the dosage and release pattern of nucleic acid drugs can help achieve personalized treatment.	It is suitable for creating customized treatment plans to meet the unique needs of patients.
Microfluidics Technology	Efficient preparation and screening of nucleic acid drugs using microfluidic technology aim to enhance the homogeneity and efficiency of formulations.	Efficient preparation and screening of nucleic acid drugs using microfluidic technology aim to enhance the homogeneity and efficiency of formulations.

Highlights of Nucleic Acid Preparation Technology

Formulation preparation technologies can be combined with a wide range of drug discovery and development processes, accommodating various types of nucleic acid drugs such as mRNA, siRNA, and others.
All types of technologies can significantly enhance the stability of nucleic acid drugs and extend their effectiveness period.
By adopting modern production processes, high yield and high purity can be ensured to meet commercialization needs.
Nanocrystal technology and solid dispersion technology are utilized to enhance the solubility and absorption rate of nucleic acid drugs in the body.
Personalized and precise drug formulation is achieved through advanced 3D printing technology and microfluidic technology.

Custom Nucleic Acid Formulation Development Services

With our advanced technology platform and rich expertise, CD Formulation helps customers develop various types of nucleic acid formulations for different therapeutic needs, spanning from oral and injectable to transdermal routes.

Oral Nucleic Acid Formulation Development

Innovative formulation technologies that enable nucleic acid drugs to be efficiently absorbed through the gastrointestinal tract have shown great potential for oral drug applications.

Injectable Nucleic Acid Formulation Development

Injectable formulations need to be stable and biocompatible in vivo, which is particularly important for efficient gene therapy and vaccination.

Ophthalmic Nucleic Acid Formulation Development

Nucleic acid drugs for ophthalmic diseases must penetrate the corneal and intraocular barriers to enable effective topical therapy.

Nasal Nucleic Acid Formulation Development

Nasal formulations deliver nucleic acids directly to the nasal mucosa, bypassing hepatic first-pass effects and providing a rapid response.

Transdermal Nucleic Acid Formulation Development

Transdermal nucleic acid formulation is a non-invasive method of delivering nucleic acid drugs to the body, bypassing the side effects and inconvenience of internal administration and injections.

CD Formulation boasts a professional technical team and advanced R&D equipment, dedicated to delivering high-quality nucleic acid formulation services. If you require assistance with nucleic acid formulation development, please don't hesitate to contact us to jointly promote the innovation and development of nucleic acid drugs.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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