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Microfluidics Technology for Nucleic Acid Formulations

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Microfluidics technology for nucleic acid formulations and bioanalysis has been widely used in the fields of drug formulation and bioanalysis. It facilitates the rapid screening of new drugs, optimization of the preparation process, and promotes the advancement of biomedical research and material science. Through this advanced technology, CD Formulation is dedicated to providing more efficient and reliable solutions for drug development and research.

Advantages of Microfluidics Technology for Nucleic Acid Formulations

Microfluidics is the precise manipulation of fluids in micro- and nanoscale spaces, enabling miniaturization to a few square centimeters on a chip for essential functions in biology, chemistry, and other laboratories. These functions include sample preparation, reactions, separations, and assays. The fundamental feature and greatest advantage of microfluidics lie in the flexible combination and scale integration of multiple unit technologies on an overall controllable tiny platform. The benefits of microfluidic technology in nucleic acid preparation are mainly evident in the following aspects.

Fig.1 Advantages of microfluidics technology. (CD Formulation)

Types of Microfluidics Technologies for Nucleic Acid Formulations

CD Formulation offers microfluidic technologies that provide significant advantages in the field of nucleic acid formulation, enabling efficient and personalized nucleic acid drug development through precise control and diverse preparation pathways. We offer the following types of technologies.

Items	Descriptions
Microdroplet Microfluidics Technology	By forming and manipulating microdroplets in a microfluidic channel, each microdroplet can package and process various nucleic acid molecules.
Continuous Flow Microfluidics Technology	Relying on the characteristics of laminar flow within the microfluidic channel, samples are separated and reacted along the channel based on their distinct physicochemical properties.
Digital Microfluidics Technology	Precise manipulation of droplet movement, splitting, fusion, and mixing can be achieved through electrical wetting or other physical effects.
Lab-on-a-Chip Technology Technology	Integrate multiple experimental steps, such as nucleic acid extraction, amplification, and detection, onto a microfluidic chip to achieve automation and integrated operation.

Our Workflow for Preparing Nucleic Acid Formulations Using Microfluidic Technology

Fig.2 Overview of the iterative 3D printing process Fig.2 Flow chart of nucleic acid formulation preparation. (CD Formulation)

Design and Development

Based on customer requirements and scientific principles, and combined with the latest microfluidic technology, design and develop a suitable microfluidic chip and control system.

Material Selection

Selection of suitable nucleic acid molecules (e.g., siRNA, mRNA, DNA, etc.) and other necessary raw materials (including buffers, protectants, encapsulation materials, etc.) is essential to ensure the biocompatibility and stability of the materials.

Microdroplet Generation

In microfluidic chips, homogeneous microdroplets are generated by precisely controlling the liquid flow rate and pressure. These microdroplets contain the desired nucleic acid formulation components.

Droplet Processing

After droplet generation, the microdroplets undergo further processing using the microfluidic technology platform. This includes mixing, separation, reaction, and cooling steps to ensure that each droplet meets the established quality standards.

Detection and Characterization

Highly sophisticated testing equipment, such as high-resolution microscopy, mass spectrometry, and nuclear magnetic resonance (NMR), is used to fully characterize the generated microdroplets of nucleic acid formulations. This ensures that their size, consistency, encapsulation efficiency, and stability meet the expected requirements.

Highlights of Nucleic Acid Preparation Using Microfluidic Technology

Microfluidics enables precise control of the formulation preparation process, including particle size, shape, and surface modification, thereby enhancing drug consistency and reproducibility.
Microfluidic systems enable rapid and efficient mixing of chemicals, reducing preparation time and increasing yield.
Microfluidics enables the integration of multiple functional units into a tiny platform, allowing for automation and high-throughput control of the entire process from sample preparation, mixing, reactions, to detection.

Custom Nucleic Acid Formulation Development Services

Microfluidic technology demonstrates a wide range of potential applications in the preparation of nucleic acid formulations. These formulations can be utilized to create various dosage forms to cater to different delivery modes and therapeutic requirements.

Oral Nucleic Acid Formulation Development

Microfluidics can be used to prepare oral nucleic acid formulations, such as capsules, tablets, and particles, with good bioavailability and stability.

Injectable Nucleic Acid Formulation Development

Microfluidic technology can precisely control the preparation process of nucleic acid drugs, forming nanoparticles, liposomes, and other structures to enhance the stability and targeted delivery of drugs.

Ophthalmic Nucleic Acid Formulation Development

Microfluidic technology can produce uniform nanoparticles with controlled particle size to improve drug retention time and penetration in the eye, thereby enhancing therapeutic efficacy.

Nasal Nucleic Acid Formulation Development

Utilizing microfluidic technology, particles like nanocapsules or microgels can be prepared. These particles can effectively cross the nasal mucosal barrier, enabling more direct and rapid drug delivery.

Transdermal Nucleic Acid Formulation Development

Microfluidic technology enables the preparation of small, uniform microemulsions or nanocarriers that can efficiently penetrate the skin barrier and enhance the effectiveness of transdermal drug absorption.

Publication Data

Technology: Preparation of drugs by microfluidic technology

Journal: Molecular Pharmaceutics

IF: 4.5

Published: 2020

Results:

Drug delivery systems (DDSs) have great potential to improve the treatment of a wide range of diseases, especially microbial infections and cancer. However, formulation procedures for DDSs remain challenging, especially at the nanoscale. Reducing batch-to-batch variation and increasing productivity are some of the fundamental requirements to accelerate the translation of DDSs from small-scale to industrialized levels. To address these issues, microfluidics has emerged as an alternative to traditional bench-scale methods. Through precise control of fluid flow and rapid mixing, microfluidic systems can be used to fabricate and design different types of DDSs with specific properties for efficient delivery of a wide range of drugs and genetic material. This review discusses the principles of controlled rapid mixing in different microfluidic strategies for the production of DDSs. In addition, the impact of microfluidic device design and parameters on the type and properties of DDS formulations is evaluated, and recent applications in drug and gene delivery are considered.

Fig.3 Microfluidics for the preparation of drug. (Tomeh M A, et al., 2020)

CD Formulation offers customized nucleic acid formulation solutions and has the flexibility to adjust microfluidic channel design and system parameters based on our customers' specific needs to achieve optimal preparation results. Contact us for our comprehensive one-stop service that covers the entire process from design and experimentation to large-scale production.

References

Tomeh M A, Zhao X. Recent advances in microfluidics for the preparation of drug and gene delivery systems. Mol. Pharm. 2020, 17(12): 4421-4434.

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