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Lipid Nanocarrier Drug Delivery System Platforms

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Lipid nanoparticles (LNPs) have emerged as a promising nanocarrier system in recent years, particularly for the delivery of nucleic acid drugs. As a leading company in the development of advanced drug delivery systems, CD Formulation is committed to creating efficient, stable, and biocompatible lipid nanoparticle delivery platforms.

Advantages of Lipid Nanocarrier Drug Delivery Systems

Lipid nanocarrier systems, which are constructed from lipid structures, have garnered significant attention for their applications in nucleic acid drug delivery. Liposomes, spherical vesicles composed of cholesterol and naturally occurring, non-toxic phospholipids, represent the most common type of lipid nanocarrier. With advancements in gene therapy and RNA interference (RNAi) technologies, the effectiveness and safety of these delivery systems have become the focal point of research. Due to their unique structure and properties, lipid nanocarriers can protect nucleic acid drugs while facilitating efficient and targeted delivery.

Fig.1 Advantages of lipid nanocarrier drug delivery platforms Fig.1 Features of lipid nanocarrier drug delivery platform. (CD Formulation)

Types of Lipid Nanocarrier Drug Delivery Platforms

Lipid nanocarrier system platforms have become ideal for delivering nucleic acid drugs and other therapeutic molecules due to their excellent biocompatibility and multiple drug loading capabilities. Currently, we provide the following types of platform:

Items	Descriptions	Characteristics
Lipid Nanoparticle Platform	Lipid nanoparticles possess a monolayer structure consisting of hydrophilic heads and hydrophobic tails, with a core formed by reverse micelles, typically ranging in size from 20 to 100 nm.	This lipid nanoparticle platform effectively transports oligonucleotides, such as siRNA and miRNA, safeguarding these nucleic acid drugs from enzymatic degradation and improving their stability within the body.
Liposome Platform	A liposome is a phospholipid bilayer structure that features a hydrophilic core for encapsulating hydrophilic small molecule drugs, while its hydrophobic layer is designed to carry hydrophobic drugs. The particle size of liposomes typically ranges from 50 to 1000 nm.	Liposomes can encapsulate and protect nucleic acid drugs while also enabling targeted delivery through surface modifications, such as PEGylation and antibody modification.
Solid Lipid Nanoparticle Platform	Solid lipid nanoparticles consist of surfactants in the outer shell and solid lipids in the inner core. They can encapsulate both hydrophilic and hydrophobic small molecule drugs, with particle sizes ranging from 40 to 1000 nm.	Solid lipid nanoparticle platform offers high stability due to their solid core and are well-suited for the delivery of various types of nucleic acid drugs, such as siRNA and antibody RNA.
Nanostructured Lipid Carrier Platform	The shell of a nanostructured lipid carrier is composed of surfactants, while the interior consists of both solid and liquid lipids. This structure enables the carrier to transport small molecule drugs that are either hydrophilic or hydrophobic, with particle sizes ranging from 40 to 1000 nm.	The nanostructured lipid carrier platform provides versatility in delivering gene editing tools, such as the CRISPR-Cas9 system. Its hybrid solid-liquid structure enables the encapsulation and protection of various forms of nucleic acid drugs, as well as the ability to modulate the rate of drug release by altering the internal lipid composition.
Liposomal Polycomplex (LPP) Nanodelivery Platform	The platform consists of a bilayer structure featuring a core of polymer-coated mRNA molecules encapsulated within a bilayer shell of phospholipids.	As a non-viral gene delivery vector, LPP integrates the benefits of both polymers and liposomes, demonstrating exceptional stability, lower cytotoxicity, high gene transfection efficiency, and the capability to gradually release mRNA molecules as the polymer degrades.

Our Solutions for Lipid Nanocarrier Drug Delivery Platforms

CD Formulation provides solutions for LNP delivery platforms, addressing several key areas, including:

Drug Encapsulation and Optimization

Design and optimize the formulation of LNPs based on the properties of the drug and specific requirements to enhance encapsulation efficiency and biocompatibility

Production and Scale-Up

Adopt an advanced nanoparticle preparation process to enhance production efficiency and yield.

Characterization and Analysis

A comprehensive characterization of LNPs is conducted through assessments of particle size, surface potential, drug release rate, and other indicators to ensure that their performance meets clinical requirements.

Highlights of Lipid Nanocarrier Drug Delivery Platforms

Lipid nanoparticles can be loaded with both hydrophobic and hydrophilic drugs, and in particular can efficiently load various nucleic acids (e.g., small interfering RNA, siRNA; antisense oligonucleotide, ASO).
By varying the lipid composition, the drug release rate can be adjusted to meet different therapeutic needs, e.g., slow release or fast release.
Lipid nanoparticles have a small particle size (typically 20-100 nm), which allows them to effectively cross cell membranes and improve drug absorption and utilization.

Services Provided by the Lipid Nanocarrier Drug Delivery Platforms

CD Formulation's lipid nanocarrier drug delivery platform focuses on providing efficient drug delivery solutions for nucleic acid therapies.

Lipid-based Nanoparticle Development Services

Whether for mRNA, siRNA, or other types of nucleic acid drugs, we can customize the most suitable delivery vehicles based on customer needs, significantly enhancing therapeutic efficacy while minimizing side effects, thereby supporting the development and application of nucleic acid drugs.

Publication Data

Technology: Delivering drugs by lipid nanocarrier systems

Journal: ACS omega

IF: 3.7

Published: 2021

Results:

Nanocarriers are extremely important for drug delivery and the development of nanomedicine technology. Depending on the composition, nanocarriers can be categorized as polymeric nanocarriers, lipid nanocarriers, viral nanoparticles or inorganic nanoparticles. Lipid nanocarrier systems have received much attention over the years due to their remarkable features such as high drug loading capacity, low toxicity, good bioavailability and biocompatibility, stability in the gastrointestinal tract, controlled release, and simple scale-up and validation process. Nanocarriers still have some drawbacks such as poor drug permeability, limited drug encapsulation and poor targeting. These drawbacks can be overcome by surface modification. Surface-modified nanocarriers can achieve controlled release, improved permeation efficiency and targeted drug delivery. In this review, the authors summarize numerous lipid-based nanocarriers and their functionalization through various surface modifiers such as polymers, ligands, surfactants and fatty acids.

Fig.2 Surface modification of lipid-based nanocarriers. (Priya S, et al., 2022)

Lipid nanocarrier drug delivery platform has shown their great potential in nucleic acid drug delivery, providing revolutionary therapeutics for cancer, genetic diseases, novel vaccines and more. Based on CD Formulation's advanced technology platform and stable and reliable preparation process, it is continuously advancing the application of lipid nanoparticles in nucleic acid drug delivery. Contact us and we will customize an exclusive solution for you.

References

Priya S, Desai V M, Singhvi G. Surface modification of lipid-based nanocarriers: a potential approach to enhance targeted drug delivery. ACS omega. 2022, 8(1): 74-86.

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