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Nucleic Acid Customization Services

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Relying on our advanced molecular biology platform and experienced nucleic acid R&D and production team, CD Formulation offers high-quality, customized, and large-scale nucleic acid custom synthesis services. Our platform not only provides standard, unmodified nucleic acids but also produces complex nucleic acids that require multiple modifications and precisely matched nucleic acid drugs (siRNA, Aptamer, ASO, etc.).

Why Nucleic Acid Customization?

Nucleic acid drugs are drugs with specific base sequences, including mini-nucleic acid drugs and mRNA vaccines. Nucleic acid products are now widely used in basic research as well as in the clinical diagnosis and treatment of diseases such as tumors, infectious diseases, blood diseases and neurodegenerative diseases. Compared with other drugs, nucleic acid drugs do not require complex protein modification, the preparation process is relatively simple in the production stage, and large-scale mammalian cell fermentation and protein purification are not required, which has the advantages of rich candidate targets, short R&D cycle, long-lasting efficacy, and a high success rate in clinical development. Nucleic acid drugs are of great market potential, no matter from the perspective of basic research and development to industrial application and pharmaceutical process improvement, its application prospect is very broad, which requires researchers to continuously develop and study.

Explore Our Nucleic Acid Customization Services

CD Formulation has a powerful nucleic acid custom synthesis platform and a team of experienced nucleic acid experts capable of synthesizing nucleic acids with various sequences and lengths. Moreover, we provide a variety of nucleic acid modification services, including base modification, to improve the stability and structural flexibility of the nucleic acids.

Custom Small Nucleic Acid Synthesis Services

Custom mRNA Synthesis

Nucleic Acid Modification Services

Our Solutions and Technologies for Nucleic Acid Customization

CD Formulation provides comprehensive and specialized quality control analysis to ensure the quality, safety and efficacy of nucleic acid drug products, and is an integral part of the overall development solution.

Fig.1 Analysis of nucleic acid. Fig.1 Our Solutions for Nucleic Acid Customization. (CD Formulation)

Items	Technologies	Descriptions
Nucleic Acid Sequence Analysis	Capillary Electrophoresis Mass Spectrometry Bioinformatics Analysis Enzyme Sequencing High-throughput Sequencing	Capillary electrophoresis, mass spectrometry and other techniques are used to accurately determine nucleic acid sequences to ensure that they are consistent with the intended design.
Physicochemical Analysis	UV-Vis Absorption Spectroscopy Dynamic Light Scattering (DLS) Thermal Analysis Spectroscopy Chromatography	Determination of basic physicochemical parameters such as concentration, pH, ionic strength, melting point, etc.
Bioactivity Analysis	Enzyme Activity Assay Gene Expression Analysis Proteomics Analysis	Evaluate the targeting and biological activity of nucleic acid drugs using cellular assays or animal models.
Stability Analysis	Accelerated Stability Assay Light Stability Assay Thermodynamic Analysis pH Stability Analysis Chemical Stability Analysis Microbiological Testing	Examine the changes in physicochemical and biological properties of nucleic acid drugs over time under various conditions (such as temperature, light, pH, etc.).
Impurity Analysis	Capillary Electrophoresis (CE) Gel Electrophoresis Liquid Chromatography Mass Spectrometry (MS) Nuclear Magnetic Resonance (NMR)	Detects structural impurities such as nucleic acid strand breaks, mismatched bases, chemical modifications, etc.
Safety Analysis	Cytotoxicity Determination Genotoxicity Analysis Immunogenicity Assay Bioactivity Analysis Pharmacokinetic Analysis Toxicology Studies	Evaluate safety indicators such as cytotoxicity, immunogenicity, and genotoxicity.

Our Deliverables and Reports

Product types: ASO, siRNA, Aptamer, mRNA, etc.

Synthesized amount: from microgram to gram.

Modification types: there are more than 200 types of modifications available, and the range of modification options is expanding based on customers' requirements. Customized modification services are offered for reagents provided by customers.

Phase reports: sequence design results, synthetic sequence QC report, modification product QC report, experimental methodology development program, experimental test report, screening and validation report, and pharmacodynamic study report.

Why Choose Us for Nucleic Acid Customization?

We can provide integrated services for nucleic acids, including all aspects of custom design, process development, small-scale test validation, scale-up synthesis, and quality control of nucleic acids.
We have an experienced R&D team and an advanced nucleic acid synthesis technology platform. We have mastered all kinds of nucleic acid modification processes, such as the custom synthesis of phosphoric acid, bases, sugar bases and more.
We have advanced analytical and testing equipment, such as HPLC/MS, to analyze the physical and chemical properties of each batch of products.

Publication Data

Technology: Preparation of nucleic acids by solid-phase synthesis technology

Journal: Bioorganic Chemistry

IF: 4.5

Published: 2023

Results:

The authors state that solid-phase synthesis is the preferred method for manufacturing oligonucleotide in quantities ranging from a few micrograms for research to several kilograms for therapeutic or commercial use. However, for large-scale oligonucleotide production, scale-up and hazardous waste generation poses challenges, necessitating the investigation of alternative synthesis techniques. In this study, the authors review the current state of development, advantages, and difficulties of recently reported alternatives to support based on controlled pore glass, and discuss the importance of support selection for solving problems that arise during oligonucleotide synthesis.

Fig. 2 Various ways of synthesizing nucleic acids. Fig. 2 Chemical methods for nucleic acids synthesis. (Jolanta Brzezinska. et al., 2023)

CD Formulation, as a professional nucleic acid drug developer, can not only customize ASOs, siRNAs, mRNAs, etc., but also provide nucleic acid modification services for customers. If you are interested in our service, please feel free to contact us, we will provide the most efficient solution for your research.

References

Jolanta Brzezinska, et al. From CPG to hybrid support: Review on the approaches in nucleic acids synthesis in various media. Bioorganic Chemistry, 2023, 140.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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