Polymer-Based Nanoparticle Delivery System Platforms

Polymer nanoparticles are excellent materials for nucleic acid drug delivery because of their biodegradability, water solubility, biocompatibility, biomimetic properties, and storage stability. CD Formulation has developed a polymer-based nanoparticle delivery system platform for clients, offering professional solutions for nucleic acid drug delivery and expediting drug research progress.

About Polymer-Based Nanoparticle Drugs Delivery System

Polymer nanomaterials exhibit diverse drug delivery capabilities. Drugs can be encapsulated within the nanomaterials, wrapped in polymer molecules, chemically bonded to the polymers, or attached to the surface of the nanomaterials. This versatility enables the delivery of both hydrophobic and hydrophilic compounds. By modifying the composition, stability, responsiveness, and surface charge of the polymer nanomaterials, researchers can precisely control the drug loading capacity and release kinetics.

Polymer Delivery Carriers

• Polymer Microsphere
• Polymer Micelle
• Dendrimer
• ...

Fig.1 Polymer-based drug delivery systems. (Ding L, et al., 2024)

Types of Polymer-Based Nanoparticle Delivery System Platforms

CD Formulation offers a diverse range of polymer-based nanoparticle delivery systems designed for the administration of various types of nucleic acid drugs. Leveraging the unique properties and benefits of polymers, we provide the following types of polymer drug delivery platforms:

Polymer Microsphere Drug Delivery Platform

Polymer microspheres are typically composed of biodegradable polymers, such as PLGA (poly(lactic-co-glycolic acid)), which can encapsulate nucleic acid drugs, enhancing their efficacy and stability through controlled release.

Polymer Micelle Drug Delivery Platform

Formed from block copolymers, these nanomicelles can encapsulate hydrophobic drugs within their hydrophobic core while simultaneously enclosing hydrophilic nucleic acids in the hydrophilic shell. This structure enhances the stability and bioavailability of the drugs and nucleic acids in vivo.

Polymer Nanoparticle Drug Delivery Platform

These nanoparticles can be produced using various methods, such as nanoprecipitation and emulsion-solvent evaporation, to facilitate the efficient delivery of nucleic acid drugs.

Polyelectrolyte Complexes (PECs) Drug Delivery Platform

Formed through the electrostatic interaction between cationic polymers and anionic nucleic acids, these self-assembled complexes play a crucial role in protecting and delivering nucleic acid-based drugs.

Dendrimer Drug Delivery Platform

Highly branched synthetic polymers with multiple terminal functionalities can be utilized for the encapsulation and delivery of nucleic acid drugs, thereby enhancing their stability and delivery efficiency in vivo.

Our Solutions for Polymer-Based Nanoparticle Delivery Systems

As an innovative delivery system, polymer nanomaterials have emerged as essential tools for nucleic acid drug delivery, owing to their exceptional biocompatibility, tunability, and biodegradability. By harnessing the unique properties of polymers, CD Formulation consistently explores and optimizes various types of polymer nanomaterials to develop efficient and safe nucleic acid delivery solutions.

Optimization of Formulations with Polymer Nanoparticles and Nucleic Acid Drugs

After selecting the appropriate polymers, adjusting the ratio of polymer to nucleic acid can optimize encapsulation efficiency and enhance particle characteristics.

Construction of Delivery Systems

Technologies such as electrospinning are employed to blend polymer solutions with nucleic acids, resulting in the formation of uniform nanoparticles.

Surface Modification of Polymer Nanoparticles

Introducing targeting ligands, such as antibodies or peptides, on the surface of nanoparticles or coating them with materials like polyethylene oxide (PEO) enhances cellular selectivity and uptake efficiency while increasing biocompatibility and reducing immune responses.

Quality Control

A variety of characterization techniques are employed to assess the properties of polymer nanoparticles and to quantitatively analyze the encapsulation efficiency of nucleic acid drugs.

Characterization of Polymer-Based Nanoparticle Delivery Systems

• Dynamic Light Scattering (DLS) Testing
• Nanoparticle Tracking Analysis (NTA)
• Transmission Electron Microscopy (TEM) Testing
• Scanning Electron Microscopy (SEM) Testing
• UV-Visible Spectroscopy Testing
• Fluorescence Testing
• In Vitro Release Experiments
• Dialysis Testing
• Stability Testing
• Zeta Potential Measurement
• Fourier Transform Infrared Spectroscopy (FTIR) Testing

Highlights of Polymer-Based Nanoparticle Delivery Systems

• We employ cutting-edge polymer nanoparticle technology to ensure that drugs are precisely and efficiently delivered to their target locations, maximizing therapeutic efficacy while minimizing side effects.
• Based on the characteristics of different drugs and the needs of patients, we offer customized solutions to ensure the suitability and effectiveness of the delivery system.
• Our platform significantly enhances drug stability and bioavailability, ensuring that the drugs exert a long-lasting and stable effect in the body.
• Our team consists of top experts in the field of drug delivery, providing you with comprehensive technical support and consulting services.

Services Provided by the Polymer-Based Nanoparticle Delivery Systems

CD Formulation's polymer nanoparticle drug delivery platform offers specialized and reliable services to support you at every stage of nucleic acid drug development.

Publication Data

CD Formulation's polymer nanoparticle drug delivery platform offers high-end support for your research and clinical applications. Contact us, and we can help you overcome challenges in drug delivery.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.