Protein Nanoparticles Delivery System Platforms

CD Formulation is dedicated to developing a range of protein nanoparticle-based drug delivery platforms. By employing various preparation methods and selecting and modifying different proteins, we can offer personalized and efficient drug delivery solutions tailored to meet diverse clinical needs.

Advantages of Protein Nanoparticles Delivery System

Due to their small size, protein nanoparticles can be transported through cells via endocytosis. These nanoparticles offer several advantages as drug delivery systems, including biodegradability, stability, surface modification, ease of size control, and high biocompatibility. In particular, the stability, activity, and half-life of drugs can be enhanced by protecting them from enzymatic degradation and renal clearance. Because of their non-antigenic properties, protein nanoparticles are suitable for various targeted therapies, including lung delivery, cancer treatment, oncology therapies, and vaccines.

Fig.1 Advantages of protein nanoparticles. (CD Formulation)

Types of Protein Nanoparticle Delivery Platforms

CD Formulation's protein nanoparticle platform enhances overall therapeutic efficacy by optimizing the delivery of drugs and nucleic acids, thereby increasing the stability, potency, and specificity of the treatment. Below are the various types of protein nanoparticle platforms.

Filipin Protein Nanoparticle Delivery Platforms

Drug molecules primarily bind to filipin proteins through electrostatic interactions, hydrogen bonding, and/or hydrophobic interactions. Filipin protein nanoparticles also possess a high drug loading capacity and adjustable release properties, making them widely utilized in drug delivery systems.

Human Serum Albumin Nanoparticle Delivery Platforms

Reactive groups on the surface of human serum albumin (HSA) nanoparticles, including amino, thiol, and carboxyl groups, facilitate covalent ligand binding and surface modification. HSA exhibits excellent ligand binding properties, making it suitable for loading a variety of drugs for delivery through the circulatory system. Additionally, HSA possesses high stability and multiple binding affinity sites, allowing for the loading of high concentrations of therapeutic drugs.

Gelatin Nanoparticle Delivery Platforms

Gelatin nanoparticles are widely used to encapsulate DNA and RNA. When gelatin is utilized to create nanoparticles, it must be physically, biologically, or chemically cross-linked with various cross-linking agents (e.g., glutaraldehyde, GA) to enhance mechanical strength and reduce the rate of decomposition and solubility in aqueous solutions.

Lipoprotein Nanoparticle Delivery Platforms

Lipoprotein nanoparticles present promising alternatives to synthetic nanocarriers for drug delivery, owing to their biocompatibility, non-immunogenicity, biodegradability, and inherent targeting capabilities. Compared to non-lipoprotein nanoparticles, lipoproteins exhibit a relatively long circulating half-life, typically ranging from 48 to 72 hours. Drugs and nucleic acids encapsulated within lipoprotein nanoparticles can be biologically targeted, leveraging the natural targeting properties of the protein.

Design Methods for Protein Nanoparticles

As a drug delivery system, the primary objective of designing nanoparticles is to control their particle size, surface area, and surface properties. This ensures that the nanoparticles, which carry the required amount of drug, can achieve site-specific action by releasing the active agent, thereby exhibiting the desired pharmacological activity.

Fig.2 Protein-based nanoparticles for drug delivery purposes. (Martínez-López A L, et al., 2020)

Highlights of Protein Nanoparticle Delivery Platforms

• The use of natural protein materials ensures that the platform is highly biocompatible, thereby reducing the risk of immune reactions.
• With precisely designed protein nanoparticles, we can achieve efficient delivery of drugs or genes, thereby enhancing therapeutic effects.
• The platform facilitates the encapsulation and delivery of a diverse array of drugs and genes targeting various therapeutic areas, including cancer, infectious diseases, and genetic disorders.
• Leading manufacturing processes and advanced technical equipment are employed to optimize the quality and performance of each nanoparticle.

Custom Nucleic Acid Formulation Carrier Services

By meticulously designing, optimizing, and developing protein nanoparticles, CD Formulation aims to enhance the efficiency and precision of drug delivery, minimize side effects, and improve drug bioavailability. We provide a comprehensive range of protein nanoparticle design platforms, encompassing everything from material selection to final product manufacturing.

Publication Data

CD Formulation is equipped to address a diverse array of drug delivery requirements, enhancing the safety and efficacy of therapeutic options. If you are interested in our protein nanoparticle delivery platform, please do not hesitate to contact us so we can collaborate on advancing drug delivery technology.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.