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Nucleic Acid Drug Preparation Technology

Inquiry

CD Formulation's nucleic acid drug synthesis platform is equipped with state-of-the-art equipment and technology to synthesize small nucleic acids and mRNAs in the milligram to kilogram range. The platform not only provides standard, unmodified nucleic acid molecules but also produces complex nucleic acid molecules that require multiple modifications, precisely matching nucleic acid drug development (siRNA, aptamer, ASO, etc.) as well as other nucleic acid research areas.

Advantages of Nucleic Acid Drug Preparation Technology

Nucleic acid drugs are innovative therapeutics based on nucleic acid molecules that treat a variety of diseases, including genetic disorders, cancers, and viral infections, by affecting gene expression or modifying gene function. Leveraging our advanced preparation technology platform, we offer comprehensive nucleic acid drug discovery and development services, which encompass genetic engineering technology, solid-phase synthesis technology, and enzymatic synthesis technology. The benefits of our nucleic acid drug preparation technologies include the following:

Fig.1 Advantages of nucleic acid drug preparation. (CD Formulation)

Our Technology Platform for Nucleic Acid Drug Preparation

CD Formulation possesses leading synthetic biology technologies and is committed to combining technology and methodology to establish a comprehensive system for optimizing advanced technology development and innovative drug applications. This ensures the provision of high-quality nucleic acid products to customers.

Solid Phase Synthesis Technology

Enzymatic Synthesis Technology

Genetic Engineering Technology

This technology enables large-scale production of high-quality nucleic acids and is particularly suitable for the production of complex large molecule RNAs, such as mRNA vaccines, macrocyclic RNAs, and gene editing-related nucleic acids. With the help of host cell expression systems, efficient nucleic acid production and predetermined modifications can be realized to further enhance the functionality and stability of drugs.

Highlights of Nucleic Acid Drug Preparation Technology

Nucleic acid preparation technologies can be applied to DNA, RNA, and various other types of nucleic acid samples to meet diverse experimental requirements.
Combining a flexible development and manufacturing approach with key foundational capabilities, such as analytical methodologies and regulatory compliance support, contributes to rapid success in today's rapidly evolving nucleic acid formulations market.
A professional laboratory technology team utilizes standardized procedures to ensure that nucleic acid concentration, purity, integrity, and other indicators meet experimental requirements, thereby establishing a reliable database for subsequent analysis.

Our Solutions for Customized Nucleic Acid Drugs

CD Formulation's team is well-versed in new route design and route optimization. With our proficiency in problem-solving and high project success rate, we are capable of providing the following high-quality custom nucleic acid synthesis services to our customers.

Custom Small Nucleic Acid Synthesis

Our advanced mini-nucleic acid synthesis and modification technologies enable us to precisely control the sequence, chemical structure, and conformation of nucleic acids to produce highly pure customized mini-nucleic acid drugs. We employ mild synthesis conditions to maximize the biological activity of the mini-nucleic acids. This precision and high activity form the foundation for the development of highly targeted and effective mini-nucleic acid drugs.

Custom mRNA Synthesis

We also have a unique advantage in mRNA drug synthesis and preparation. We can utilize enzyme synthesis and genetic engineering technology to efficiently synthesize various functionalized mRNA molecules. Additionally, we have mastered the technology of mRNA nanopreparation, which enables us to effectively encapsulate and deliver mRNAs to target cells. This process improves the stability and transcription efficiency of mRNAs in vivo.

Publication Data

Technology: Nucleic acid synthesis by solid-phase technology

Journal: Chemical Society Reviews

IF: 40.4

Published: 2020

Results:

DNA and RNA labeling is a rapidly growing field that brings together several areas of research: on the one hand, synthetic and biophysical chemists have developed new fluorescent markers and isoforms of nucleobases, as well as faster and more selective bioorthogonal reactions. On the other hand, the number of enzymes available for post-synthesis and site-specific labeling of nucleic acids has increased significantly. With the development of protein engineering and cytogenetic manipulation, intracellular and cell-specific labeling has become possible. In this review, the authors will provide a structured overview of nucleic acid covalent labeling methods and highlight notable developments, especially recent examples. The bulk of this review will focus on fluorescent labeling; however, the principles can often be readily applied to other markers as well. The authors will begin with fully chemical approaches, followed by chemoenzymatic strategies and nucleases, and finally metabolic labeling of nucleic acids. Each section is subdivided into direct (or one-step) labeling and two-step labeling methods, and will begin with DNA before dealing with RNA.

Fig.2 Nucleic acid synthesis by solid-phase technology Fig.2 Strategies for labeling nucleic acids based on solid-phase synthesis. (Klöcker N, et al., 2020)

CD Formulation is proficient in independently designing nucleic acid drug synthesis pathways and possesses extensive experience in working with complex compounds. We provide the global life sciences industry with efficient, flexible, and high-quality custom nucleic acid drugs. Contact us for specialized solutions tailored to your nucleic acid drug needs.

References

Klöcker N, Weissenboeck F P, Rentmeister A. Covalent labeling of nucleic acids. Chem. Soc. Rev. 2020, 49(23): 8749-8773.

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