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Peptide Nanoparticles Delivery Platforms

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CD Formulation possesses extensive expertise and a wealth of technological advancements in the development and application of peptide nanomaterials. Our cutting-edge peptide drug delivery platform significantly enhances drug stability, bioavailability, and targeting, thereby accelerating the processes of new drug development and clinical application.

About Peptide Nanoparticles Delivery Platforms

Peptides are common natural polymers composed of multiple amino acids that can form secondary structures, such as α-helices and β-sheets, through hydrogen bonding. Peptides serve as highly effective building blocks for emerging drug delivery systems. They can carry a variety of active functional groups (such as -COOH, -OH, -NH₂, and -SH) on their side chains, which can undergo various chemical modifications to enhance the functionality of drug delivery systems.

Advantages of Peptide Nanoparticles

Easy Metabolism
Low Immunogenicity
Low Toxicity
..

Fig.1 Advantages of peptide nanoparticles. (CD Formulation)

Types of Peptide Nanoparticle Delivery Platforms

CD Formulation, a company specializing in the research and development of drug delivery systems, offers a diverse range of peptide nanoparticle drug delivery platforms. Below are some of the types of peptide nanoparticle drug delivery platforms we provide.

Items	Descriptions
Targeted Peptide Drug Delivery Platforms	Targeted peptides can serve as effective targeting moieties for nanodrug delivery systems. By harnessing the capability of these peptides to specifically recognize their targets, nucleic acid drugs can be precisely delivered to the intended organ or cell. This targeted approach enhances drug concentration and improves the therapeutic effect in the desired area.
Penetrating Peptide Drug Delivery Platform	Penetrating peptides are a class of peptides capable of transporting macromolecules into cells, and their ability to penetrate does not rely on classical endocytosis. By combining tumor-targeting peptides with cell-penetrating peptides, it is possible to selectively direct drug delivery to specific tissues and cells, thereby enhancing therapeutic efficacy.
Responsive Peptide Drug Delivery Platform	The responsive peptide drug delivery platform is an advanced nano-loading system designed to leverage the unique properties of peptide responses to external stimuli, such as pH, enzymes, and temperature. This platform enables the targeted release of drugs in specific pathological environments, such as low pH levels or the presence of particular enzymes in the tumor microenvironment, thereby facilitating precise drug release and enhancing treatment efficacy.
Assembled Peptide Drug Delivery Platform	The assembled peptide drug delivery platform constructs nanoscale drug carriers by harnessing the self-assembling properties of peptide molecules. These self-assembled peptide nanomaterials exhibit greater stability and extended blood circulation times compared to individual peptide molecules, and they can be more effectively targeted through surface functionalization.

Our Solution of Peptide Nanoparticle Delivery Platforms

CD Formulation's peptide nanomaterials drug delivery platform offers efficient, safe, and controlled drug delivery solutions through advanced technological development. The goal is to enhance therapeutic efficacy while minimizing side effects, thereby providing innovative solutions for the treatment of various diseases.

Nucleic Acid Drug Delivery Services

PNP delivery platforms can deliver nucleic acid drugs, such as siRNAs and mRNAs, to cells via local or systemic administration. These PNP delivery systems not only enhance the efficiency of cellular uptake and endosomal release but also have the capacity to carry multiple siRNA segments, enabling the simultaneous silencing of multiple target genes.

Peptide Nanoparticle Characterization Services

Our peptide nanoparticle delivery platform offers expert characterization solutions that employ a range of advanced technological tools, including dynamic light scattering (DLS), transmission electron microscopy (TEM), and nuclear magnetic resonance (NMR). These tools enable a comprehensive analysis of particle size, morphology, surface charge, and dispersibility, ensuring the quality and performance of formulations for various biomedical applications.

Highlights of Peptide Nanoparticle Delivery Platforms

Using targeted peptide and penetrating peptide technologies, drugs can be delivered with precision, significantly increasing their concentration in target tissues or cells. This approach reduces side effects and enhances therapeutic efficacy.
The platform utilizes responsive peptide design to facilitate the intelligent release of drugs under specific conditions (e.g., pH, enzyme concentration, etc.), thereby enhancing therapeutic accuracy and efficacy.
By combining tumor-targeting peptides with cell-penetrating peptides, selective drug release and transmembrane delivery are achieved, significantly enhancing the therapeutic efficacy and safety of medications.
Peptide nanomaterials with self-assembled structures exhibit prolonged blood circulation times, enhancing the sustained release of drugs within the body.

Custom Nucleic Acid Formulation Carrier Services

CD Formulation's peptide nanoparticles drug delivery platform offers customers tailored carrier customization services aimed at ensuring efficient and precise drug delivery to target sites, thereby enhancing efficacy and minimizing side effects.

Peptide-Based Carrier Development Services

We offer customized peptide vector development services tailored for researchers and pharmaceutical companies. Our specific services include, but are not limited to, targeted peptide design, penetrating peptide screening, and the synthesis and optimization of reactive peptide nanomaterials.

Publication Data

Technology: Peptide nanoparticle platforms for drug delivery

Journal: Talanta

IF: 6.1

Published: 2021

Results:

In this paper, we successfully established dipeptide nanoparticles/cyclic peptide/aptamer AS1411/influenza hemagglutinin peptide/siRNA/doxorubicin (DNPs/Clolar/AS1411/HA/RNA/DOX) multifunctional nanoparticles for specific delivery, cancer therapy, and bioimaging. It is ideal for the synergistic treatment of multiple drugs. First, the DNPs formed from the self-assembly of dipeptides are non-toxic, providing safe and biocompatible effects. Second, from the perspective of the multi-functional nanoparticles for nano-drug tumors imaging monitoring, AS1411 and HA were used as cell permits for enhancing the specificity of cell drug delivery ability and improving the endosomal escape, respectively. Third, multifunctional nanoparticles synergized with three drugs, Clolar, siRNA and DOX, to improve the therapeutic effect on tumors. Both cellular and in vivo experiments showed that multidrug synergistic therapy was superior to monotherapy. Therefore, the proposal of multifunctional nanoparticles provides new ideas for these hybrid anticancer drugs based on peptide self-assembled nanocarriers and their wide application in biomedicine.

Fig.2 Peptide nanoparticles for drug delivery Fig.2 Self-assembled peptide nanoparticles for co-drug delivery. (Guo Y, et al., 2021)

CD Formulation provides a diverse array of research and development tools, along with technical support, through our peptide nanomaterial drug delivery platform. If you are seeking innovative and efficient drug delivery solutions, please do not hesitate to contact us.

References

Guo Y, Hu Y, Zheng X, et al. Self-assembled peptide nanoparticles with endosome escaping permits for co-drug delivery. Talanta, 2021, 221: 121572.

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