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3D Printing Technology for Nucleic Acid Formulations

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With the development of gene therapy and personalized medicine, nucleic acid formulations are emerging as potential treatments for a wide range of diseases. CD Formulation introduces advanced 3D printing technology, which enables precise control of the composition and structure of the formulation, thereby enhancing the efficacy and stability of the drug.

Advantages of 3D Printing for Nucleic Acid Formulations

3D printing technology enables the design of various printed models to customize formulations with specific drug structures, drug release capabilities, and drug dosages to meet the needs of different individuals. Additionally, the computer-controlled printing manufacturing model allows artificial intelligence (AI) to be applied to 3D printing for retrieving, screening, predicting, and constructing drug formulations that meet expectations.

Fig.1 Advantages of 3D printing technology. (CD Formulation)

Printing Structurally Specific Drugs

3D printing enables precise control over the type, distribution, and content of the drug in each layer, stacking them on top of one another to create structurally specific drug formulations.

Printing Drugs with Precise Release Capabilities

The release of 3D printed drugs can be influenced by a variety of factors. Studying the mechanisms of these factors can help understand the release of 3D printed drugs and achieve precise control over drug release.

Printing Drugs with Dose Control

3D printing technology can design pills with the correct dosage and precision, thus preventing toxicity issues resulting from overdosing patients.

Printing Customized Drugs Predicted by AI

Using AI technology, researchers can accurately analyze and measure the required release capacity and composition of a drug to screen for the appropriate customized medication.

Classification of 3D Printing Technologies for Nucleic Acid Formulations

CD Formulation utilizes advanced 3D printing technology in the development of nucleic acid formulations. This not only expands the possibilities for preparing nucleic acid drugs but also enhances the stability and bioavailability of the formulations. 3D printing enables the customization of nucleic acid formulation treatments by accurately regulating drug dosages and release profiles, thereby enhancing therapeutic effectiveness and minimizing side effects. Below are some of the key 3D printing technologies.

Items	Descriptions
Binder Jetting Technology	Binder jetting technology refers to the formation of solid bridges between powders and particles, based on binders, or the formation of particles through dissolution and recrystallization.
Material Extrusion Technology	Material extrusion is the most widely used 3D printing technology, where material is extruded from the nozzle of the machine during the printing process and can be printed on any substrate.
Light Curing Technology	Light-curing molding technology utilizes liquid photosensitive resins that cure quickly when exposed to a UV laser beam to produce 3D printed products.

Characterization of Nucleic Acid Preparations Produced by 3D Printing Technology

Scanning Electron Microscopy (SEM) Analysis
X-ray Computed Tomography (XCT) Analysis
Differential Scanning Calorimetry (DSC) Analysis
Fourier Transform Infrared Spectroscopy (FTIR) Analysis
Raman Spectroscopy Analysis
Compression and Stretching Testing
In Vitro Release Studies
Cytotoxicity and Biocompatibility Testing
Stability Testing
...

Highlights of Nucleic Acid Preparation Using 3D Printing Technology

Through 3D printing technology, we can design and fabricate complex drug carrier structures. All of these complex carriers can improve the bioavailability of drugs and enable targeted delivery, making treatment more efficient and precise.
With 3D printing, we are able to create nucleic acid formulations in a variety of dosage forms. This diverse selection of dosage forms broadens the range of applications for nucleic acid drugs and meets the needs of different patients and therapeutic regimens.
Our 3D printing technology allows for customized manufacturing based on individual patient needs, with the flexibility to adjust either the dosage, shape or release mechanism.

Custom Nucleic Acid Formulation Development Services

In nucleic acid drug delivery systems, 3D printing technology has opened up new avenues for drug preparation with its precision and flexibility. CD Formulation has successfully developed a wide range of nucleic acid formulation dosage forms to meet various therapeutic needs and patient populations using different 3D printing technologies, such as oral, injectable, nasal, ophthalmic, and transdermal formulations.

Oral Nucleic Acid Formulation Development

We utilize 3D printing technology to blend nucleic acid drugs to create oral tablets or capsules. These formulations can be tailored for release in the gastrointestinal tract, ensuring efficient absorption of the drug at specific sites while minimizing degradation of nucleic acids in the gastrointestinal tract.

Injectable Nucleic Acid Formulation Development

With 3D printing, we can create innovative injectable devices like microneedle arrays, enabling efficient and painless drug delivery through the skin barrier and into the bloodstream. Moreover, 3D printing enables customization of drug dosages and release rates.

Ophthalmic Nucleic Acid Formulation Development

Ophthalmic formulations of nucleic acid drugs need to overcome the barrier of the cornea and conjunctiva. We utilize 3D printing technology to create gels, ophthalmic films, or eye drops that are applicable for ocular use. These formulations enable a consistent release of the drug over an extended period, enhancing therapeutic effectiveness and minimizing eye irritation.

Nasal Nucleic Acid Formulation Development

For nasal formulations, 3D printing technology provides an effective way to deliver nucleic acid drugs through the nasal mucosa to the systemic circulation or central nervous system. We utilize 3D printing technology to prepare nasal spray devices that can accurately control the release rate and dosage of the drug, improving the bioavailability of the drug.

Transdermal Nucleic Acid Formulation Development

Transdermal formulations are a non-invasive delivery route for absorbing drugs through the skin. By leveraging 3D printing technology, we can create transdermal patches with microneedles that penetrate the stratum corneum of the skin to deliver nucleic acid drugs into the epidermis or dermis for extended drug release and efficient systemic absorption.

Publication Data

Technology: 3D printing technology for the preparation of pharmaceutical materials

Journal: Microchimica Acta

IF: 6.232

Published: 2021

Results:

The authors have utilized 3-D printing to fabricate tools ranging from common laboratory hardware to fluidic systems, sample handling platforms, sensing structures, and complete full-featured analytical equipment. Over time, this technology has become increasingly affordable, making it more popular than commonly used manufacturing processes such as hot embossing, soft lithography, injection molding and microdrilling. However, to better utilize 3D printing manufacturing methods, it is important to fully understand their benefits and limitations, which are also directly related to the properties of the materials used for printing. Cost, print resolution, chemical and biological compatibility of the material, design complexity, robustness of the printed object, and integration with commercially available systems are important aspects that need to be weighed against the intended task.

Fig.2 Overview of the iterative 3D printing process Fig.2 General scheme of the iterative 3D printing process. (Ambrosi A, et al., 2021)

CD Formulation utilizes 3D printing technology to drive scientific and industrial advances in nucleic acid formulation preparation, greatly enhancing drug stability, efficacy, and patient compliance. Contact us for a safer, more efficient, and personalized solution for your project.

References

Ambrosi A, Bonanni A. How 3D printing can boost advances in analytical and bioanalytical chemistry. Microchimica Acta. 2021, 188: 1-17.

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