CD Formulation offers a stable and efficient drug dosage form development platform process. From oral, injectable, nasal to ophthalmic dosage forms, we have the capability to quickly and effectively screen long-term stable nucleic acid formulation prescriptions synthesized to support a broad spectrum of drug dosage form development efforts. Our global technical team possesses years of experience and expertise in the pharmaceutical field to assist you in easily overcoming the formulation challenges associated with next-generation drug development.

Advantages of Nucleic Acid Dosage Form Development

The development of various nucleic acid dosage forms is crucial for advancing the clinical application of nucleic acid drugs. This progress not only enhances therapeutic efficacy but also improves patient compliance and safety.

Fig.1 Different types of dosage forms.(CD Formulation)

Dosage form can alter the drug absorption rate and bioavailability

The same dose of the same drug, when formulated into different dosage forms, will result in varying speeds of action. Injections, inhalation aerosols, and other dosage forms are commonly employed in emergency treatment due to their quick onset of action. Extended and controlled-release dosage forms can significantly alter the drug absorption rate, thereby prolonging its effectiveness.

Different dosage forms can alter the adverse effects of drugs

The so-called adverse drug reaction occurs when a drug causes irritation or damage to the body. For instance, when aspirin tablets are taken orally, they can lead to adverse reactions such as nausea and vomiting. However, using aspirin capsules or aspirin tablets with an enteric coating can reduce or eliminate stomach irritation. Additionally, aspirin capsules can provide delayed release, ensuring a long-lasting effect.

Different dosage forms can lead to changes in drug targeting

Targeted dosage forms increase the concentration of the drug at a specific site and reduce systemic adverse effects. Some intravenous agents contain nanoparticle carriers, such as liposomes and microspheres. Once they enter the bloodstream, these particles can be effectively retained in tumor tissues due to the larger gaps in the endothelial cells of blood vessels in areas like tumors, enabling them to target the specific site.

Explore Our Dosage Form Development Services for Nucleic Acid Therapeutic Formulation

Through years of development, CD Formulation has established an outstanding process development team equipped with international standard equipment and instrumentation. This has significantly enhanced our capability and flexibility in nucleic acid dosage form development to cater to the diverse needs of our customers. Currently, we are able to conduct various types of pharmaceutical dosage form development based on our customers' specifications.

Our Solutions for Dosage Form Development

Technology Platform

Fig.2 Formulation development platform. (CD Formulation)

Available Technologies

• Spray Drying Solid Dispersions Technology
• Hot Melt Extrusion Technology
• Nanosuspensions Technology
• Liquid-filled capsules Technology

Testing Capabilities

• Chromatography: UPLC, HPLC, GC, IC, CE
• Solid State Characterization: DSC, PSD, Polarized light microscope
• Identification: FT-IR, UV
• Routine Testing: moisture, solubility, loss on drying, scorch residue, etc.
• Others: ICP-MS, viscosity, surface tension, osmotic pressure

Why Choose Us for Dosage Form Development Services?

Experienced Team

The members of the formulation development team possess robust expertise in formulation development and extensive experience in data analysis. They have actively contributed to and led the development of numerous nucleic acid formulation projects.

Wide Range of Development Categories

We provide extensive coverage of all nucleic acid drugs in the biopharmaceutical industry, including ASOs, siRNAs, aptamers, mRNAs, and more.

Wide Coverage of Development Technologies

Covering a wide range of formulation technologies and processes in the biopharmaceutical industry, the completed formulation prescriptions can be applied to oral formulations, injection formulations, nasal formulations, etc. Additionally, package compatibility studies are also conducted.

Introduction of international advanced instruments and equipment

Nucleic acid drug stability studies are conducted using internationally recognized first-line equipment, which is employed following appropriate validation. The equipment undergoes regular maintenance and calibration to guarantee precise and dependable data.

Customized Service

High-quality customized services include targeted dosage form design for customer projects, in accordance with regulations and requirements for temperature, oxidation, light, and other accelerated stability tests. Long-term stability tests are conducted for prescription screening to fully assess the stability of the target proteins in a specific formulation.

CD Formulation has a strong infrastructure and extensive facilities in the field of formulation type development. Presently, the company focuses on producing oral and injectable formulations that cover the entire product supply cycle, from initial development to large-scale production of nucleic acid drugs. Supported by a team of skilled and experienced professionals and cutting-edge production equipment, we are committed to providing high-quality formulation products to our clients. Contact us and allow us to assist you in maximizing the potential of your drug formulations effortlessly, effectively, and promptly.