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Genetic Engineering Technology for Nucleic Acid Drugs

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CD Formulation can design and prepare various therapeutic nucleic acid molecules, such as siRNA and mRNA, using genetic engineering technology platforms based on DNA recombination and gene synthesis technologies. These nucleic acid drugs can directly regulate gene expression and serve preventive and therapeutic purposes.

Advantages of Genetic Engineering Technology in Developing Nucleic Acid Drugs

Genetic engineering refers to the use of engineering design methods at the gene level to design and create a new biological line with a new trait that can be stably inherited by future generations. Its core technology is DNA recombination technology, which involves using genetic material from donor organisms or synthetic genes. This genetic material is cleaved by restriction enzymes and then connected to an appropriate vector to form a recombinant DNA molecule. Subsequently, the recombinant DNA molecules are introduced into recipient cells or organisms to create genetically modified organisms that exhibit specific traits according to the design.

Currently, the advantages of genetic engineering techniques for developing nucleic acid drugs include the following.

High Specificity - Nucleic acid drugs can precisely recognize and bind to specific gene sequences with extremely high specificity, reducing the impact on other genes or non-target tissues.
Versatility - Nucleic acid drugs can be designed to target a variety of entities, such as genes, mRNAs, microRNAs, etc., encompassing nearly all types of diseases.
Individualized Treatment - Genetic engineering technology can customize personalized treatment plans based on the genetic characteristics of patients and enhance treatment outcomes.
Long-lasting Therapeutic Effect - Some nucleic acid drugs, such as gene editing tools like CRISPR/Cas9, can permanently modify genes and provide long-lasting therapeutic effects.
Controllable Production - Nucleic acid drugs prepared through genetic engineering can be manufactured in a standardized way on laboratory and industrial scales to guarantee quality and consistency.

Expression Systems for Nucleic Acid Drugs Prepared by Genetic Engineering Technology

CD Formulation has outstanding technological innovation in the field of genetic engineering. We have extensive experience with bacterial, yeast, and other expression systems and can provide advanced technical support to significantly enhance nucleic acid production and quality. The systems we offer have various applications and benefits in different organisms. Below are some common expression systems:

Fig.1 Systems for the preparation of nucleic acid drugs. Fig.1 Expression systems for nucleic acid drugs preparation. (CD Formulation)

Systems	Descriptions
Bacterial Expression System	Bacterial expression systems include Escherichia coli (E. coli), Bacillus subtilis, and others. Among them, E. coli is the most commonly used bacterial expression system, known for its fast growth, easy handling, and high yield.
Yeast Expression System	Saccharomyces cerevisiae can perform specific eukaryotic post-translational modifications, such as glycosylation. It is well-suited for producing nucleic acid drugs that necessitate these modifications.
Insect Cell Expression System	The baculovirus-insect cell system is utilized for expressing complex eukaryotic proteins capable of undergoing post-translational modifications. It is suitable for the expression of large, multi-subunit nucleic acid drugs.
Mammalian Cell Expression System	CHO cells are widely used to produce biologics, particularly nucleic acid drugs that necessitate precise post-translational modifications.

Preparation Process of Genetic Engineering Technology for Nucleic Acid Drugs

The principle of genetic engineering for the preparation of nucleic acid drugs is mainly based on the manipulation and editing of DNA or RNA sequences of organisms by artificial methods to generate nucleic acid molecules with therapeutic effects. These nucleic acid molecules can precisely target specific genes or gene products, interfere with the expression of harmful genes, repair mutated genes, or replace the function of missing genes, in order to achieve the purpose of treating diseases. The process of preparing nucleic acids by genetic engineering technology includes target design, nucleic acid sequence synthesis, vector construction, cell transfection/transduction, and production scale-up.

Fig.2 Genetic engineering technology preparation process. Fig.2 Preparation process of genetic engineering technology. (CD Formulation)

Highlights of Genetic Engineering Technology for Nucleic Acid Drugs

Genetic engineering techniques enable the precise design and synthesis of target nucleic acid fragments, such as siRNAs, ASOs, and mRNAs, according to specific sequence requirements.
Utilizing multiple expression systems, various types of nucleic acid molecules can be efficiently produced to meet diverse drug development requirements.
The genetic engineering technology platform is equipped with efficient large-scale production capabilities. By optimizing the expression systems, high-yield nucleic acid drug production can be achieved to meet clinical and commercialization needs.

Custom Nucleic Acid Drug Development Services

With our advanced technology in genetically engineered nucleic acids, CD Formulation can rapidly design customized nucleic acid drug candidates for specific diseases and efficiently manufacture them using its established platform for genetically engineered drug production.

Custom Small Nucleic Acid Synthesis

Genetic engineering technology enables customized mini-nucleic acid drug services by utilizing advanced DNA and RNA synthesis technologies, along with efficient expression systems and precise delivery pathways. This approach is used to develop drugs based on molecules such as oligonucleotides, small interfering RNAs (siRNAs), and microRNAs (miRNAs).

Custom mRNA Synthesis

CD Formulation provides a modern genetic engineering technology platform focused on the development and production of custom mRNA drugs. We utilize state-of-the-art expression systems for efficient, high-density mRNA synthesis and expression.

CD Formulation offers services for customizing nucleic acid drugs using genetic engineering technology, covering the entire process from early research and development to large-scale production. Whether it's mRNA vaccines, siRNA, or ASO, our technology platform can provide high-quality customization services. Contact us for customized solutions to accelerate clinical translation and improve market competitiveness.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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