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Nucleic Acid Drug Delivery Platforms

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CD Formulation's nucleic acid drug delivery technology platform is dedicated to developing new nucleic acid drug delivery technologies for novel nucleic acid drugs and therapies such as nucleic acid vaccines and gene therapy. Additionally, the platform provides customized nucleic acid drug synthesis services based on demand, facilitating the translation and application of basic research.

Types of Nucleic Acid Drug Delivery Systems

Nucleic acid drug delivery systems can be categorized into the following types:

Fig.1 Classess of nucleic acid drug delivery systems. Fig.1 Types of nucleic acid drug delivery systems. (CD Formulation)

Viral Vectors

Utilizing genetically engineered viral vectors (such as adenovirus, lentivirus, retrovirus) to deliver nucleic acid drugs to target cells. These systems offer high delivery efficiency but pose potential immunogenicity and safety concerns.

Lipid Nanoparticle Carriers

These systems encapsulate nucleic acid drugs in lipid bilayers or nanoparticles, aiding in protecting the nucleic acids' stability and promoting their cellular uptake. This type of delivery system is commonly used in mRNA vaccines.

Polymer Nanoparticle Carriers

Polymer-based nanoparticles, made from natural or synthetic polymers, encapsulate nucleic acid drugs to enhance their stability and biodistribution, enabling controlled release and reducing side effects.

Peptide Nanoparticle Carriers

Specific transmembrane peptides or cell-penetrating peptides (CPPs) can bind to nucleic acids, assisting them in crossing the cell membrane into cells.

Protein Nanoparticle Carriers

Incorporating or binding nucleic acid drugs to specific protein nanoparticles not only protects the nucleic acids from degradation but also leverages the targeting functions of proteins to improve the specificity of drug delivery.

Exosome Carriers

Exosomes are natural extracellular vesicles that can carry nucleic acid drugs into cells via endocytosis, offering low toxicity and high biocompatibility attributes advantageous for precision drug delivery.

Our Nucleic Acid Drug Delivery Platforms

Our Solutions of Nucleic Acid Drug Delivery Platforms

CD Formulation's nucleic acid drug delivery technology platforms utilize advanced nanotechnology for manufacturing and characterization. Our platforms encompass various stages of nucleic acid drug delivery, including early research and development (R&D), micro-preparation, and quality control. Additionally, the platform is equipped with instruments for measuring nanoparticle size and conducting quality testing, as well as performance characterization of drug delivery systems.

Preparation of Nucleic Acid Nanoparticles for Drug Delivery Systems

Preparation Methods	Descriptions
Lipid Nanoparticle Assembly	Nucleic acids are encapsulated in lipid bilayers to form nanoparticles through ultrasonic emulsification or thin-film evaporation.
Double Emulsion Method	Nucleic acids are encapsulated in polymeric nanoparticles through an emulsification and solvent evaporation process that utilizes a water-in-oil-in-water (W/O/W) structure.
Magnetic Nanoparticle Method	Encapsulation of nucleic acids in magnetic materials, such as iron oxide, enables targeted delivery and internalization through the application of magnetic fields.
Microfluidics Method	Precise control and scale-up preparation of nanoparticles through microfluidic chips, ensuring high reproducibility and a favorable particle size distribution.
Freeze-Drying Method	A nucleic acid solution is combined with a carrier and rapidly frozen. Subsequently, the solvent is removed through sublimation to yield dried nanoparticles.

Performance Characterization of Drug Delivery Systems

Items	Descriptions
Particle Size and Distribution Analysis	The average particle size of nanoparticles and their distribution are determined using methods such as Dynamic Light Scattering (DLS) or Laser Particle Size Analysis (LPSA) to evaluate the homogeneity and stability of the particles.
Morphological Analysis	The morphology, structure, and surface features of nanoparticles are examined using TEM or SEM to provide detailed morphological information about the particles.
Zeta Potential Analysis	Zeta potential of nanoparticles is measured using laser Doppler electrophoresis to evaluate the surface charge properties of the particles. This assessment helps predict their stability and interactions within a biological environment.
Drug Loading and Encapsulation Rate Analysis	HPLC and UV-Vis were employed to assess the drug loading and encapsulation efficiency of nucleic acid drugs within the delivery system. This analysis also aimed to evaluate the delivery system's capacity for drug loading.
Stability Studies	Assess the physical and chemical stability of nanoparticles by conducting a series of physicochemical tests, including TGA and DSC.

Custom Drug Delivery Carrier Development Services

Our nucleic acid drug delivery platform provides custom drug delivery carrier development services. Leveraging advanced nanotechnology and precise material science, we design and optimize various delivery systems, including nanoparticles, liposomes, and polymer carriers, according to client specifications. Our platform offers comprehensive support from formulation design and process development to scale-up production. Using state-of-the-art characterization and evaluation techniques, we ensure efficient transport and targeting capabilities of the carriers, tailored to meet specific therapeutic needs of different nucleic acid drugs.

Highlights of Nucleic Acid Drug Delivery Platforms

Diverse Delivery Systems - Including GalNAc conjugated delivery systems, lipid nanoparticles, polymer-based nanoparticles, exosomes, inorganic nanoparticles, peptide nanoparticles, and protein nanoparticles.
Precise RNA Targeting - Employing cutting-edge nanotechnology to ensure precise targeting of RNA drugs in vivo, enhancing therapeutic efficacy.
Customized Services - Providing tailored delivery carriers to significantly improve the efficiency of personalized drug treatments.
Comprehensive Technical Platforms - Covering preparation, characterization, and application, ensuring efficient development and utilization of delivery carriers.

Publication Data

Technology: Multiple delivery system platforms for nucleic acid drug delivery

Journal: Journal of Controlled Release

IF: 10.5

Published: 2020

Results:

Nucleic acids have not been widely recognized as optimal drug delivery materials. Indeed, unmodified nucleases are unstable and too hydrophilic for cellular uptake and payload encapsulation, and may also cause unintended biological reactions, such as activation of the immune system and prolongation of the blood coagulation pathway. However, three major areas of recent development around nucleic acids warrant reconsideration of their role in drug delivery. These areas include DNA/RNA nanotechnology, multivalent nucleic acid nanostructures, and nucleic acid aptamers, which offer, respectively, the ability to design nanostructures with an unparalleled level of structural control, the ability to completely reverse some of the biological properties of linear/cyclic nucleic acids, and the ability to use all-nucleic-acid constructs for antibody-level targeting.

Fig.2 Drug delivery strategies for nucleic acids Fig.2 Nucleic acid-based drug delivery strategies. (Tan X, et al., 2020)

Through CD Formulation's platform, customers can achieve effective nucleic acid drug delivery systems to enhance drug stability and target cell delivery efficiency, advancing the clinical application of new therapeutic methods. If you are interested in our platform and services, please feel free to contact us.

References

Tan X, Jia F, Wang P, et al. Nucleic acid-based drug delivery strategies. J Control Release. 2020, 323: 240-252.

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