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Coating Technology for Nucleic Acid Formulations

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Nucleic acid formulations (e.g., DNA and RNA vaccines, RNAi therapeutics, etc.) are increasingly being emphasized for their potential in gene therapy and molecular biology research. CD Formulation has developed a series of advanced coating technology platforms to enhance the stability, bioavailability, and targeted delivery of nucleic acid formulations.

Advantages of Coating Technology for Nucleic Acid Formulations

Coating technology can effectively isolate light, oxygen, humidity and other environmental factors on the stability of the drug damage, improve the stability of the drug, increase the storage cycle of the drug, improve the palatability of the drug, to achieve the drug in the stomach or intestines of the localization of the target release.

Fig.1 Advantages of coating technology. (CD Formulation)

Types of Coating Technology for Nucleic Acid Formulations

CD Formulation has not only solved the problem of stability of nucleic acid drugs in organisms through advanced coating technology but also improved the targeting and controlled release of drugs, thus achieving better therapeutic effects. Below are some common types of coating technologies and their characteristics.

Items	Descriptions	Characteristics
Film Coating Technology	Film coating mainly consists of polymers, plasticizers, and pigments that form a thin protective layer.	Film coating technology improves the stability of the drug, controls the release of the drug, protects the drug from environmental factors (e.g., moisture, light), and also masks the bitter taste and odor of the drug.
Sugar Coating Technology	Sugar coating technology involves applying multiple layers of sweeteners, such as syrups.	This technology enhances the appearance and taste of medicines, especially for children's medications.
Enteric Coating Technology	Enteric coating technology utilizes polymers that are stable in stomach acid but dissolve in the alkaline environment of the intestine.	This technology protects the drug from destruction in the stomach and ensures release in the intestine, making it suitable for drugs that need to avoid gastric irritation and for drugs that require absorption in the intestine.
Controlled Release Coating Technology	Controlled release coating technology enables the sustained, controlled, or burst release of drugs through specific polymers and coating technologies.	This technology allows for the modulation of the release rate of the drug, prolonging the duration of efficacy, reducing the frequency of administration, and improving patient compliance.
Functional Coating Technology	Functional coating technology includes, but is not limited to, moisture-proof coatings and taste improvement coatings.	This technology has multifunctional properties, such as preventing moisture absorption of drugs and enhancing the taste experience.
Nanoscale Coating Technology	Nanoscale coating technology utilizes nanoscale materials for coating.	This technology offers ultra-high dispersibility and bioavailability for targeted release, enhancing drug absorption.

Highlights of Nucleic Acid Preparation Using Coating Technology

We have a team of experienced researchers and engineers dedicated to developing cutting-edge coating technologies to guarantee the optimal performance of nucleic acid formulations.
We can provide a one-stop service, from drug design and selection of coating technology to final productization, with comprehensive support to meet customer-specific needs.
Through strict quality control and testing standards, we ensure the stability and reliability of each batch of products, providing customers with peace of mind.
Continuous technology development and innovation, combined with the latest coating technologies, enable us to offer our customers cutting-edge solutions to advance the development of nucleic acid drugs.

Custom Nucleic Acid Formulation Development Services

CD Formulation's coating technology services cover multiple stages from initial development to commercial production, ensuring the efficacy and safety of nucleic acid drugs in vivo, and providing customized solutions for our clients.

Oral Nucleic Acid Formulation Development

Coating technology can enhance the solubility and stability of nucleic acids, ensure the efficient release of drugs in the gastrointestinal tract, and improve bioavailability.

Injectable Nucleic Acid Formulation Development

The coating technology enhances the stability and targeting of nucleic acid formulations, reduces drug degradation in the body, and improves efficacy.

Ophthalmic Nucleic Acid Formulation Development

Coating can improve the residence time of the drug in the eye, enhance the adhesion of ophthalmic preparations, and effectively enhance the therapeutic effect.

Nasal Nucleic Acid Formulation Development

Coating technology helps protect the nucleic acid drug, enhances its absorption in the nasal cavity, increases the local concentration, and improves bioavailability.

Transdermal Nucleic Acid Formulation Development

Utilizing coating technology can achieve slow release and long duration of drugs, enhancing the permeability of nucleic acid drugs through the skin to achieve the therapeutic effect.

Publication Data

Technology: Therapeutic disease utilizing biopolymer coating technology

Journal: Advanced Science

IF: 14.3

Published: 2023

Results:

The use of structures capable of localized release of biologically active molecules can improve the efficiency of disease treatment and better integration of implantable bionic devices. Strategic design of biopolymer coatings can be used to design optimal release profiles based on the task at hand. This paper reviews advances in this area using drug release from bone, brain, eye and cardiovascular implants as examples. The focus in these areas is to emphasize that both hard and soft tissue implants can benefit from controlled local drug delivery. The composition of biopolymers used to achieve appropriate drug delivery to selected tissue types and their corresponding outcomes are also highlighted. Finally, key factors in designing drug-loaded biopolymer coatings for biomedical implants are emphasized.

Fig.2 Therapeutic release profile from nonresponsive and responsive biopolymer coatings. (Talebian S, et al., 2023)

CD Formulation offers a cutting-edge coating technology platform that provides innovative solutions for nucleic acid formulations. Our technology is adaptable to meet individual requirements, improving the stability and effectiveness of nucleic acid drugs. Contact us and we will collaborate with our customers to propel the progress of nucleic acid formulations, contributing to the advancement of medicine and biotechnology.

References

Talebian S, Mendes B, Conniot J, et al. Biopolymeric coatings for local release of therapeutics from biomedical implants. Adv. Sci. 2023, 10(12): 2207603.

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