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Exosome Delivery System Platforms

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Exosomes, as natural vehicles for intercellular communication, are biocompatible and well-targeted, enabling the effective protection and delivery of nucleic acid drugs. CD Formulation offers an exosome drug delivery platform that combines advanced technology with extensive research and development experience, focusing on the use of exosomes as an innovative drug delivery vehicle.

Advantages of Exosome Delivery System

Exosomes are membrane-bound vesicles containing a variety of components that play roles in both biological and pathological processes. Since their discovery, they have been utilized as diagnostic biomarkers and potential drug delivery vehicles, facilitating the transfer of biological materials to recipient cells based on their size and functional capabilities. The characteristics of exosomes, including biocompatibility, tumor-targeting preference, adjustable targeting efficiency, and stability, render them appealing carriers for a range of diseases and cancer therapies.

Fig.1 Advantages of exosome delivery system Fig.1 Characteristics of exosomes. (CD Formulation)

Exosome Loading Technologies for Nucleic Acid Drugs

Passive Loading Technology

This method involves co-incubating drugs with exosomes or exosome donor cells, facilitating the entry of drugs into the exosomes or their secretion by the exosome donor cells that contain the loaded drugs.

Active Loading Technology

Active encapsulation employs mechanical techniques to temporarily and reversibly disrupt the exosome membrane, facilitating drug entry. Common methods include sonication, electroporation, freeze-thaw cycles, co-extrusion, and the use of surfactants.

Our Solutions of Exosome Drug Delivery System Platform

CD Formulation is committed to offering an advanced exosome delivery platform designed to address the delivery requirements of various nucleic acid drugs, including antisense oligonucleotides (ASOs), messenger RNA (mRNA), small interfering RNA (siRNA), and microRNA (miRNA). Our technology platform is founded on the principles of efficiency, precision, and safety, and it develops multiple innovative solutions for the effective delivery and targeted release of nucleic acid drugs in vivo, significantly improving therapeutic outcomes.

Items	Descriptions
Delivery of ASOs Drugs	Exosomes can stabilize ASOs in vivo, making them less susceptible to degradation and facilitating specific binding to target mRNA. This process ultimately reduces or suppresses the expression of pathological proteins.
Delivery of mRNA Drugs	Exosomes protect mRNA from degradation by in vivo enzymes and facilitate its effective entry into target cells, enabling successful transcription and expression of therapeutic proteins within the cells.
Delivery of siRNA Drugs	Exosome-mediated siRNA delivery effectively prevents degradation in vivo and ensures precise entry into target cells, resulting in specific gene silencing and therapeutic effects.
Delivery of miRNA Drugs	The exosome delivery platform can efficiently transport miRNA into target cells, thereby regulating gene expression at the post-transcriptional level. This method holds potential applications in the treatment of various diseases.

Characterization Technologies for Exosome Delivery System

Dynamic Light Scattering (DLS)
Nanoparticle Tracking Analysis (NTA)
Transmission Electron Microscopy (TEM)
Atomic Force Microscopy (AFM)
Enzyme-Linked Immunosorbent Assay (ELISA)
Fluorescence Correlation Microscopy (FCM)
Colorimetric Detection (CD)
Surface Plasmon Resonance (SPR) Detection
Nuclear Magnetic Resonance (NMR) Detection

Highlights of Exosome Delivery Systems

CD Formulation's exosome delivery platforms can be designed and adjusted to meet various therapeutic requirements.
Exosomes safeguard the delivered drug components, such as RNA, from enzymes and other degradation mechanisms within the body, thereby enhancing drug stability and efficacy.
Platforms can be customized to meet specific customer needs, including the source of exosomes, the type of contents, and the surface modifications of the exosomes for particular therapeutic or research purposes.

Custom Nucleic Acid Formulation Carrier Services

Through customized services and precise target optimization, CD Formulation is dedicated to enhancing the effective delivery of nucleic acid drugs. We offer comprehensive support and solutions in areas such as gene therapy and vaccine development. Our exosome delivery platform emphasizes exosome development and aims to provide innovative drug delivery solutions for the biopharmaceutical industry.

Exosome Development Services

CD Formulation provides an exosome drug delivery platform that integrates cutting-edge technology with extensive research and development experience, emphasizing the use of exosomes as novel drug delivery vehicles. We offer a comprehensive array of exosome development services, including isolation and purification, characterization, cargo loading, and functionalization modifications, to address our clients' needs in both basic research and clinical applications.

Publication Data

Technology: Exosomes platform for drug delivery

Journal: European Journal of Pharmaceutics and Biopharmaceutics

IF: 4.159

Published: 2020

Results:

Exosomes are intracellular vesicles based on cell membranes with diverse compositions that are involved in biological and pathological processes. Since their discovery, exosomes have been used as diagnostic biomarkers and as potential drug delivery vehicles based on their size and ability to transfer biomaterials to recipient cells. Properties such as biocompatibility, preferred tumor homing, tunable targeting efficiency and stability of exosomes make them compelling and excellent drug delivery vectors for a wide range of diseases and cancer therapies. In this article, the authors will provide a brief overview of exosome biogenesis, function, content, and isolation and characterization techniques.

Fig.2 Exosomes platform for drug delivery Fig.2 Exosomes as drug delivery systems. (Patil S M, et al., 2020)

CD Formulation's exosome delivery platform integrates cutting-edge science and technology to offer customers efficient, reliable, and innovative drug delivery solutions for new drug discovery and clinical applications. Contact us for a customized solution tailored to your project.

References

Patil S M, Sawant S S, Kunda N K. Exosomes as drug delivery systems: A brief overview and progress update. Eur J Pharm Biopharm. 2020, 154: 259-269.

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