Nanoparticle Development for Nanomedicine
Inquiry
Nanoparticles have gained significant interest in pharmaceutical fields due to their unique properties and potential applications. CD Formulation has been committed to nanoparticle research for many years, assisting researchers from various countries in the formulation development and commercial manufacturing of nanoparticles.
Advantages of Nanoparticles
Nanoparticles are small particles with a size between 1 and 100 nanometers, with unique physical, chemical, and biological properties, and can be used for drug delivery and imaging. Its advantages include:
- Small size: Allows them to penetrate deep into tissues and cells, making them ideal for targeted drug delivery and imaging applications.
- High surface area: Allows for increased reactivity and interaction with other molecules, making them efficient in catalysis and as sensors.
- Enhanced properties: Exhibit unique physical and chemical properties that are different from their bulk counterparts, leading to improved strength, conductivity, and optical properties, making them useful in a wide range of applications.
- Controlled release: Nanoparticles can be manipulated to release their payload in a controlled manner, allowing for sustained drug release and reducing the frequency of dosing.
- Biocompatibility: Many nanoparticles are biocompatible and non-toxic, making them suitable for use in medical applications such as drug delivery, imaging, and medical diagnostics.
- Versatile: Nanoparticles can be synthesized from a variety of materials and can be tailored to meet specific requirements for various applications.
Our Nanoparticle Development Services
CD Formulation, as a world-leading pharmaceutical service company integrating formulation development, process conversion and manufacturing, has accumulated many years of rich experience in nanomedicine formulation development and production, focusing on the formulation development of nanomedicine. We can provide formulation development and manufacturing services for the following nanoparticles including but not limited to solid lipid nanoparticles (SLNs), albumin nanoparticles, liposome nanoparticles (LNPs), polymer nanoparticles, biomimetic nanoparticles, and environmentally responsive nanoparticles according to the different needs of our customers.
Our Nanoparticle Preparation Process
We are committed to the research of the preparation process of nanoparticles. The methods of preparing nanomedicines are mainly "bottom-up" and "top-down" technologies.
- "Bottom-up" technology is the traditional precipitation method, which generates particle precipitation in the solution through chemical reactions and controls the growth of the precipitated particle size through the control of various reaction conditions to prepare nanoparticles.
- "Top-down" technology uses external force to split drugs or carrier materials down to nanometer size. The technologies for reducing particle size are mainly milling and high-pressure homogenization.
Our Solutions for Nanoparticle Fabrication
We have advanced instruments and equipment and rich experience in the fabrication of nanoparticles. We can provide a variety of nanoparticle service solutions based on our customers' existing research and development progress.
- If you have selected an active pharmaceutical ingredient (API) and carrier formula but are suffering from no effective and precise synthesis method. We can use our advanced nanomedicine preparation system to synthesize nanoparticles for you and perform process optimization and nanoparticle characterization, such as particle size, zeta potential, encapsulation efficiency, drug loading, and drug release, etc.
- If you have a selected API but no carrier formulation. We can provide you with formulation development and nanoparticle characterization, such as particle size, zeta potential, encapsulation efficiency, drug loading, and drug release, etc.
- If you have already synthesized nanoparticles and only need to characterize the nanoparticles. We can provide you with the nanoparticle characterization, such as particle size, zeta potential, encapsulation efficiency, drug loading and drug release from nanoparticles, etc.
Why Choose Us to Develop Nanoparticles?
- We have an efficient team that delivers on time, and our core technicians have excellent nanoformulation expertise, and can quickly respond to customers' needs for nanoparticle development services and customize personalized research strategies.
- We have established multiple advanced nanoparticle technology platforms based on different drug delivery characteristics, which provides us with a strong guarantee for the development of nanoparticles.
- We have a lot of experience in the formulation development and characterization services for nanoparticles including solid lipid nanoparticles (SLNs), albumin nanoparticles, liposome nanoparticles (LNPs), polymer nanoparticles, biomimetic nanoparticles, and environmentally responsive nanoparticles and are willing to provide first-class nanoparticle services.
Published Data
Technology: Machine learning-guided synthesis of nanoparticles
Journal: Nature Reviews Materials
IF: 60.458
Published: 2021
Results:
The authors examine machine learning-guided synthesis of semiconductor, metallic, carbon-based, and polymeric nanoparticles, discuss machine learning algorithms that can be used for nanoparticle synthesis, and highlight key methods for collecting large data sets. Machine learning (ML) provides a promising tool for accelerating the development of efficient protocols for nanoparticle synthesis and has the potential to be used in the synthesis of novel nanoparticles.
Here are ML-guided synthesis methods shown in this article:
Fig.1 Machine learning algorithms in nanoparticle synthesis. (Huachen Tao, et al. 2021)
CD Formulation has always been at the forefront of nanoparticle development and is pleased to be your partner in nanoparticle development. If you are interested in our nanoparticle development services, please feel free to contact us via phone or email, we will reply to you within three working days.
References
- Murthy SK. Nanoparticles in modern medicine: state of the art and future challenges. Int J Nanomedicine. 2007, 2(2):129-41.
- Altammar KA. A review on nanoparticles: characteristics, synthesis, applications, and challenges. Front Microbiol. 2023, 14:1155622.
- Huachen Tao, Tianyi Wu, Matteo Aldeghi, et al. Nanoparticle synthesis assisted by machine learning. Nature Reviews Materials. 2021,6:701-716.
How It Works
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