Biomimetic Nanoparticle Development for Nanomedicine
Inquiry
Biomimetic nanoparticles are an emerging class of nanoparticles whose surfaces are integrated or fabricated with biomaterials capable of mimicking the biological characteristics and functions of natural cells. CD Formulation utilizes cutting-edge polymeric nanoparticle preparation technology to offer clients services in developing biomimetic nanoparticles formulations that cater to customers' various requirements, such as natural protein-based biomimetic nanoparticles, cell membrane-coated biomimetic nanoparticles and biomimetic ligand nanoparticles.
Types and Advantages of Biomimetic Nanoparticles
Biomimetic nanoparticles have greatly improved biocompatibility, high target specificity, long retention time, and minimal adverse immune responses. Biomimetic nanoparticles as drug delivery systems have the following three advantages:
- Inert exclusion. Biomimetic nanoparticles physically protect incorporated drugs from damaging factors such as oxygen, light, enzymes, etc.
- Overcome barriers. Biomimetic nanoparticles can cross natural biological barriers and overcome endocytic barriers.
- Active effect. Specific activation of target biological processes.
There are various types of biomaterials that can be used to coat nanoparticles to achieve their biomimetic capabilities, such as from red blood cells, neutrophils, natural killer cells, macrophages, platelets, extracellular vesicles, and cancer cells. In addition, there are biomaterials inspired by nature, such as monoclonal antibodies, natural proteins, and viral capsids, as well as synthetic biomaterials, such as targeting peptides and aptamers. And we are good at designing and researching the fabrication of the following types of biomimetic nanoparticles.
Fig.1 Three types of biomimetic nanoparticles. (CD Formulation)
Our Biomimetic Nanoparticle Development & Customization Services
Biomimetic nanoparticles are nanoparticles with drug-loading functions that are inspired by nature and designed as carriers based on the characteristics of natural biomaterials. CD Formulation is committed to researching the following three main types of biomimetic nanoparticles, namely the preparation technology of natural protein-based, targeting ligand and cell membrane-coated biomimetic nanoparticles. We are able to provide customers with design and fabrication services for the following types of bionic nanoparticles to meet the needs of different customers.
Natural Protein-Based Biomimetic Nanoparticles
Proteins used in protein-based biomimetic nanoparticles include serum albumin, ferritin, lipoproteins, and virus-like particles. We can design and customize the following natural protein-based biomimetic nanoparticles based on our advanced design concept and rich preparation experience.
- Serum Albumin-Fabricated Nanoparticle
- Ferritin Protein Cage
- Virus-Like Particles
Cell Membrane-Coated Biomimetic Nanoparticles
We prepare the cell membrane-wrapped nanoparticles through such three key steps, that is membrane extraction, preparation and fusion of core nanocarriers. And we can customize the following cell membrane-coated biomimetic nanoparticles based on your requirements for different cell membranes.
- RBC Membrane-Coated Nanoparticles
- Immune Cell Membrane-Coated Nanoparticles
- Platelet Membrane-Coated Nanoparticles
- Cancer Cell Membrane-Coated Nanoparticles
- Exosome Membrane-Coated Nanoparticles
Biomimetic Ligand Nanoparticles
We focus on modifying the surface of nanoparticles with targeting moieties to enhance the nanoparticles' ability to actively target and accumulate in tumors. We can provide you with our customization services for biomimetic ligand nanoparticles based on the following targeting ligands.
- Folic Acid as a Targeting Ligand
- Monoclonal Antibodies (mAbs) as Targeting Ligands
- Tumor-Penetrating Peptides as Targeting Ligands
- Aptamers as Targeting Ligands
In addition to preparation of the above-mentioned biomimetic nanoparticles, we can also provide you with customizing biomimetic nanoparticles including mesoporous silica nanoparticles wrapping the cell membrane, cell membrane biomimetic modified dendritic polyamide-amine, cell membrane biomimetic polymer vesicles, disulfide bond cross-linked bioresponsive cell membrane biomimetic micelles, and cell membrane modified nanocarbon sphere materials, etc.
Our Analytical Capabilities for Biomimetic Nanoparticles
After preparing biomimetic nanoparticles, it is necessary to characterize the biomimetic nanoparticles, including characterization of their physical, chemical and biological properties. For example, cell membrane-coated biomimetic nanoparticles require confirmation that the cell membrane has successfully coated the nanoparticle surface, as well as the size, surface charge, and protein composition of the nanoparticle. We can provide you with the following characterization services for biomimetic nanoparticles including:
- Particle Size and Distribution
- Morphology
- Surface Charge and Zeta Potential
- Drug Loading
- Encapsulation Efficiency
- In Vitro Drug Release
- Stability
Why Choose Us to Develop Biomimetic Nanoparticles?
- Depending on our biomimetic nanoparticle technology platform, we can help global researchers design and fabricate natural protein-based biomimetic nanoparticles, cell membrane-coated biomimetic nanoparticles and biomimetic ligand nanoparticles.
- We have complete nanoformulation development equipment and precision analytical instruments to fully assist in the formulation development and quality control of biomimetic nanoparticles.
- We can also provide customers with various analyses and characterization of biomimetic nanoparticles including particle size and distribution, zeta potential, drug loading, etc. Our technical team can give a quick response to your requirements for biomimetic nanoparticle formulation development for nanomedicine immediately.
Published Data
Technology: Preparation method for biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs)
Journal: Nature Communications
IF: 16.6
Published: 2019
Results:
The authors constructed a kind of exosome biomimetic porous silicon nanoparticles (E-PSiNPs) effluxed by tumor cells for targeted drug delivery to cancer stem cells, which has good anti-tumor and killing cancer stem cell capabilities. Research shows that exosomes-biomimetic nanoparticles have the potential to serve as drug carriers to improve anti-cancer efficacy. This study provides a new idea for the use of exosome biomimetic nanomedicines derived from tumor cells for tumor treatment.
Here is the authors' preparation and targeted cancer chemotherapy process of DOX@E-PSiNPs.
a Schematic illustration of the preparation of DOX@E-PSiNPs.
b Schematics showing how DOX@E-PSiNPs effeciently target tumor cells after intravenous injection into tumor-bearing mice.
Fig.2 Schematic illustration of E-PSiNPs as drug carriers for targeted cancer chemotherapy. (Tuying Young, et al. 2019)
CD Formulation has rich experience in exploring biomimetic nanoparticle formulation development and can create and characterize different types of biomimetic nanoparticles to realize your drug delivery research. If you are interested in our biomimetic nanoparticle development services, please do not hesitate to contact us.
References
- Tuying Yong, Xiaoqiong Zhang, Nana Bie, et al. Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy. Nature Communications. 2019(10):3838.
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