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Nanofiber Development for Nanomedicine

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Nanofibers, as drug-controlled release carriers, have attracted widespread attention due to their large specific surface area, high porosity, easy operation and low production cost. They show great flexibility in the application of drug delivery systems. CD Formulation focuses on the nanoformulation development and has many years of experience in nanofiber manufacturing. We can provide researchers or enterprises with nanofiber preparation or technical support services according to clients' different needs.

Advantages of Nanofibers

Nanofibers typically range from a few nanometers to hundreds of nanometers in diameter, and their unique properties including extremely high surface area, tunable mechanical properties, and flexibility have made them useful in biomedical applications such as drug delivery systems and tissue scaffolds. Nanofibers have a large area of surface variable 3D topography, porosity, and adaptable surface functions. Nanofibers have their unique advantages as follows:

  • Nanofibers have a high surface-to-volume ratio.
  • Nanofibers are made by different materials and polymers.
  • Ease of the fiber functionalization and fiber deposition onto other substrates.
  • Different materials could be easily used for electrospinning, with low requirements for creating fibers.
  • Relatively low startup cost.
  • We are easy to learn the technique for nanofiber preparation and arrange commercial production.
  • Electrospun fiber deposition necessitates a lower static charge on the collecting surface and are frequently deposited on metal, glass, micro-fibrous mats, and water.

Our Nanofiber Customization Service

Nanofibers and nanofibrils are categorized according to their size, form, and content, such as metals, metal oxides, ceramics, polymers, carbon, nonporous, mesoporous, hollow, core-shell, bicomponent and multi-component. CD Formulation is committed to preparate nanofibers many years, and we can customize the following different types of nanofibers to meet our clients' requirements.

Inorganic Nanofibers

We can customize inorganic nanofibers to meet different needs based on the following inorganics, for example, oxide-based nanofibers (CuO, ZnO, SnO2, BaTiO3), sulfide-based nanofibers (ZnS), and TiO2/Bi2WO6-based, LiCl/TiO2 multi-component composite nanofibers, and metal nanofibers based on copper, nickel and silver, etc.

Carbon Nanofibers

Carbon nanofibers (CNFs), due to their high electrical conductivity, excellent mechanical strength, and promising morphological properties, and huge surface area can adsorb different sensing and therapeutic agents in diagnosis and therapy. Our scientists have also conducted extensive research on CNFs, accumulated rich experience, and can provide CNF preparation and technical support services to our customers.

Polymer-Based Nanofibers

Morphology of polymer-based nanofibers is basically flat, branched, split and ribbon-shaped nanofibers, which are widely used in different area, such as heart valves, vascular grafts, etc. We usually use electrospinning to produce ultrafine fibers with a variety of polymers, and then produce nanofibers with various morphological and structural characteristics by improving the spinneret design and collection system.

Composite Nanofibers

Composite nanofibers are characterized by large surface area, small pore size, high temperature resistance, excellent electrical conductivity, and high cycle stability. This type of nanofibers is used in many fields due to its improved physical and chemical properties. We usually customize composite nanofibers by electrospinning a polymer solution containing nanoparticles and use a polymer template process to produce composite nanofibers.

Our Nanofiber Fabrication Methods

Nanofibers can be customized by different fabrication techniques, such as "top-down" and "bottom-up" methods, physical, chemical, and biological methods, spinning or non-spinning methods. We can provide our clients with nanofiber development using the following methods.

Fig.1 Nanofiber preparation methods.Fig.1 Our nanofiber fabrication methods. (CD Formulation)

Why Choose Us to Develop Nanofibers?

  • Based on our sophisticated nanofiber preparation technology platform, CD Formulation customizes different types of high-quality nanofibers for customers, including inorganic nanofibers, carbon nanofibers, polymer-based nanofibers, and composite nanofibers.
  • We are deeply engaged in the research and update of nanofiber preparation methods, including electrospinning, self-assembly, phase separation, template synthesis, drawing, and centrifugal spinning, to ensure the preparation of nanofibers that meet quality requirements in terms of morphology and diameter, etc.
  • Equipped with advanced instruments and a skilled team, we can promptly meet your nanofiber development needs for nanomedicine.

Published Data

Technology: Fabrication Technology of Supramolecular peptide nanofiber hydrogels (SPNHs)

Journal: Advanced Science

IF: 15.1

Published: 2022

Results:

The authors introduce that supramolecular peptide nanofibrous hydrogels (SPNHs) are emerging biomaterials due to their inherent biocompatibility, satisfactory biodegradability, high purity, easy functionalization, and tunable mechanical properties. The authors also report the comprehensive application of SPNH in bone tissue engineering.

Here is an overview of supramolecular peptide nanofiber hydrogels(SPNHs) for bone tissue engineering shown in this article:

Fig.2 Supramolecular peptide nanofiber hydrogels fabrication.Fig.2 Overview of supramolecular peptide nanofiber hydrogels for bone tissue engineering. (Zhuowen Hao, et al. 2022)

CD Formulation has been developing nanofibers for many years with our nanofiber technology platform. If you have a requirement about our services, please contact us by phone or email, and our team will reply to you within three working days.

References

  1. Zhuowen Hao, Hanke Li, Yi Wang, et al. Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications. Advanced Science. 2022, 9, 2103820.
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