Oral Nanoformulation Development

Oral nanoformulations have gained significant interest in medicine fields due to their unique preparation properties and potential applications. CD Formulation has been committed to oral nanoformulation research for many years, assisting researchers from various countries in the formulation development and commercial manufacturing of oral nanoformulations.

Advantages of Nanomertials in Oral Nanoformulations

Nanomaterial-based oral nanoformulations can improve drug stability in the harsh gastrointestinal (GI) tract environment, providing opportunities for targeting specific sites in the GI tract, increasing drug solubility and bioavailability, and providing sustained release in the GI tract. Its advantages include:

Fig.1 Advantages of nanomaterials in oral nanoformulation. (CD Formulation)

Our Oral Nanoformulation Development Services

The main bottleneck affecting the bioavailability of oral nanoformulation is biological barriers including gastric acid barrier and intestinal mucosal barrier. CD Formulation is committed to researching strategies based on organic and inorganic nanomaterials to solve this problem. It provides necessary technical support to global companies or researchers in improving the bioavailability of oral nanoformulation.

Oral Nanoformulation Development Based on Organic Nanomaterials

Organic nanomaterials can be used as candidates for oral delivery carriers. They have various advantages such as biodegradability, biocompatibility, non-immunogenicity, extended delivery, and easy modification, and have been widely used in multiple oral nanoformulations. CD Formulation is committed to developing the following oral nanoformations, such as polymeric nanoparticle-based oral nanoformulation, micelle-based oral nanoformulation, liposome-based oral nanoformulation, etc...

Oral Nanoformulation Development Based on Inorganic Nanomaterials

Inorganic nanomaterials produced from non-metallic and metallic systems have unique advantages in terms of excellent physical and chemical properties and mild synthesis processes. In addition, the size, morphology, and surface functionalization of inorganic nanomaterials are more controllable and have great potential to enhance the bioavailability of oral nanoformulations. CD Formulation can provide our clients with our professional formulation development services for silica nanoparticle-based oral nanoformulation, porous nanoparticle-based oral nanoformulation, etc...

Our Strategies for Oral Nanoformulation Development

CD Formulation has advanced instruments, such as rapid nanomedicine preparation system, and rich experience in the oral nanoformulation development. We can provide organic nanomaterial or inorganic nanomaterial-based oral nanoformulation development service solutions based on our customers' existing research and development progress or new R&D requirements. Our research and development solutions include but are not limited to the following processes.

In-Depth Analysis of Drug Types and Metabolic Properties

At this stage, we conduct in-depth analysis of the physicochemical properties, pharmacokinetic properties (including absorption, distribution, metabolism, and elimination), drug targeting, and immunogenicity of your target small molecule drugs or biologic drugs.

Design of Carrier

Commonly used carrier structures include nanostructures, liposomes, hydrogels, membrane-controlled structures, and skeleton structures. We confirm the carrier type by analyzing their respective mechanisms of action and applicable drugs. It is an integral carrier (the drug will be dissolved or dispersed in the carrier matrix, and the drug will become an integral body with the delivery carrier through non-covalent bonds such as covalent bonds or electrostatic forces). Or it is a storage carrier (the drug is stored and delivered in the form of a package by the carrier, and the drug is carried to the target location and the release of the drug is controlled through the physical and chemical properties of the carrier or its modified group, such as active or passive targeting).

Nanocarrier Materials Screening and Preparation

We can screen and prepare nanocarrier materials including organic nanomaterials (polymeric nanoparticle, micelle, liposome, etc.) and inorganic nanomaterials (silica nanoparticle, porous nanoparticle, etc.).

Drug Loading Modification

Through the selection of carriers (nanomaterials), the design of drug loading methods, and the introduction of modification groups, we enable drugs to complete the circulation in the body conveniently and safely, achieve maximum utilization in the body, and achieve targeted delivery and improve transmission efficiency. and loading rate, protecting drugs, and reducing toxicity.

Targeting and Controlled Release

By decorating the drug surface with ligands that can bind to specific receptors on the disease surface, the drug can accurately reach diseased cells. At the same time, the carrier is monitored to release the active pharmaceutical ingredient at the appropriate time and location.

Evaluation and Testing

We also provide testing services such as analysis of physicochemical properties of nanomaterial components, characterization of oral nanoformulation, In vitro dissolution evaluation of oral nanoformulation, stabilization testing, and preclinical testing.

Scale-Up and Production of Oral Nanoformulation

Through research on the formulation process of oral nanoformulation, we confirm the feasibility of its scale-up and commercial production, and guide scale-up and industrial production according to customer needs.

Why Choose Us to Develop Oral Nanoformulations?

• Our core technical team has professional subject knowledge and skilled professional operation skills in the nanoformulation development, pilot scale-up production and clinical transformation, which is a professional guarantee for the smooth implementation of your project.
• We hold a variety of advanced instruments and equipment, such as rapid nanomedicine preparation system, which greatly saves raw materials and time in preparing samples during the formulation screening and optimization stages.
• We have accumulated rich experience in the formulation development of oral nanoformulations. We can provide customers with one-stop services for personalized professional research solutions, the design and preparation of nanomaterial carriers, formulation process development, quality control and scale-up production of oral nanoformulations.

Published Data

Oral nanoformulation has attracted close attention from many researchers because of its advantages such as ease of administration and good patient compliance. CD Formulation follows the golden trend in the research field and has achieved gratifying results in the nanoformulation process research and quality control research. If you are interested in our oral nanoformulation development services, please do not hesitate to contact us for more in-depth communication and discussion.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.