Nanostructured Lipid Carrier Development for Nanomedicine

CD Formulation can provide our clients with nanostructured lipid carrier development services for nanomedicines to meet the different requirements using our advanced preparation methods of nanostructured lipid carriers (NLCs). Our highly qualified nanoformulation development team can design and prepare the NLCs that can be used in a wide variety of drug delivery systems by different routes including oral, transdermal, ocular, pulmonary, and intravenous delivery systems.

Advantages of Nanostructured Lipid Carriers

Nanostructured lipid carriers (NLCs) are the second-generation solid lipid nanoparticles (SLNs), which consist of a binary mixture of solid lipids and liquid lipids with an average size of 10 -500 nm. And the NLCs can be divided into three types, such as imperfect type, amorphous type, and multiple type based on differences in their lipid and oil composition.

Fig.1 Diagrammatic presentation of imperfect, amorphous, and multiple type NLCs. (Neerupma Dhiman, et al. 2021)

The significant advantages of nanostructured lipid carriers (NLCs) include easy scale-up, drug targeting, controlled drug release profile, longer stability profile, high drug loading (DL), biocompatibility, biodegradability and non-toxicity, etc.

Our Production Techniques for Nanostructured Lipid Carriers

The main ingredients of nanostructured lipid carriers (NLCs) include solid lipids, liquid lipids, surfactants and surface modifiers. CD Formulation relies on our advanced design concept to use the following main three fabrication methods for NLCs, including high energy input methods (hot/cold pressure homogenization, high shear/high speed homogenization, and ultrasonication), lower energy input methods (microemulsion, double emulsion, phase inversion temperature, and membrane contactor), and preparation with organic solvent involvement (emulsification solvent diffusion, emulsification solvent evaporation, and Solvent injection). In addition, we can utilize spray drying technology and lyophilization technology to prolong the stability of NLCs and make them into powder, and then create suitable dosage form (such as, powder, capsule or tablet) according to the customer's different requirements.

Fig.2 NLCs fabrication methods. (Van Hong Nguyen, et al. 2022)

In addition to the above fabrication methods for nanostructured lipid carriers (NLCs), we are committed to researching emerging technologies to explore advanced technologies for NLCs fabrication to provide professional support for researchers. And the additional techniques for NLCs fabrication, such as, hydrophobic ion pairing and surface modification (including surface charge modification and surface modification for targeting delivery).

Our Analytical Capabilities for Nanostructured Lipid Carriers

The stability of nanostructured lipid carriers (NLCs) during prolonged storage can be determined by monitoring changes in particle size, zeta potential, surface morphology, drug encapsulation efficiency, crystallinity and polymorphism, etc. We can provide you with the following characterization of nanostructured lipid carriers including:

Why Choose Us to Develop Nanostructured Lipid Carriers?

• The development of NLC formulations adds the advantage of drug release regulation. We have created a nanostructured lipid carrier technology platform based on this advantage and can develop personalized NLC formulation development strategies according to the different needs of customers.
• We have a first-class R&D team to help the research and development of nanostructured lipid carriers reach a new stage, and efficiently promote NLC formulations to quickly enter clinical applications and even the market.
• We also explore and fabricate advanced preparation technology for nanostructured lipid carriers including hot/cold pressure homogenization, high shear/high-speed homogenization, microemulsion, emulsification solvent diffusion, emulsification solvent evaporation, etc.
• With our excellent professional technology and strong resource integration capabilities, we can serve our customers more professionally, including nanostructured lipid carrier production technology, characterization, in vitro drug release, stability, toxicity, and potential application research.

Publication Data

CD Formulation has always been at the forefront of nanostructured lipid carrier development for years. If you are interested in our services, please do not hesitate to contact us for in-depth discussion and communication.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.