Targeting Nanoformulation Development

Targeting nanoformulations can improve drug efficacy, reduce toxicity, improve the safety, effectiveness, reliability and patient compliance of drugs, they have increasingly received widespread attention from the global pharmaceutical community. CD Formulation has been committed to preparation of targeting nanoformulations for many years, assisting researchers or pharmaceutical companies from various countries in targeting nanoformulation development and analysis.

Classification and Advantages of Targeting Nanoformulations

Targeting nanoformulations are nanodrug delivery systems in which nanocarriers selectively concentrate and locate drugs in targeting tissues, targeting organs, targeting cells, or intracellular structures through local administration or systemic blood circulation. According to the targeted delivery mechanism, they are divided into three types, such as passive targeting nanoformulations, active targeting nanoformulations, and physical and chemical targeting nanoformulations.

Fig.1 Classification of targeting nanoformulations. (CD Formulation)

Targeting nanoformulations have good stability, high bioavailability, and good therapeutic effects. They can improve the efficacy of drugs while significantly reducing the toxic and side effects of drugs on other tissues, organs, and the whole body. Targeting nanoformulations have the following advantages:

• Improve drug solubility and reduce dosage.
• Utilize hypertonicity of tumor tissue to form the EPR effect and extend the drug's action time.
• Reduce the toxicity of drugs to normal cells, reduce the occurrence of adverse reactions, and reduce drug resistance.
• Easier to penetrate biological barriers (such as blood-bone marrow barrier, etc.) to achieve efficient drug delivery.
• Drug targeting is enhanced, increasing drug availability in target tissues.

Our Targeting Nanoformulation Development Services

CD Formulation is committed to the targeting nanoformulation development based on our advanced design concept, instruments and equipment many years. Drug targeting is essentially the interaction between functional groups, that is, the core group on the surface of the nanodrug is chemically combined with the group at the receptor site to achieve targeting purposes. Our solutions for targeting nanoformulation development according to different types of targeting nanoformulation as follows.

Passive Targeting Nanoformulations

Passive targeting nanocarriers include liposomes, emulsions, microspheres, nanocapsules and nanospheres, nanoparticles, and polymeric micelles. We will prepare the targeting nanoformulations based on different nanocarrier preparation methods, such as liposome preparation methods which include injection method, film dispersion method, ultrasonic dispersion method, reverse phase evaporation method, freeze-drying method, etc.

Active Targeting Nanoformulations

Active targeting nanoformulations are modified nanodrug carriers, including modified liposomes, modified microspheres, modified nanoparticles, etc. We can prepare the following modified nanodrug carriers.

Fig.2 Preparation of active targeting nanoformulations. (CD Formulation)

Physical and Chemical Targeting Nanoformulations

CD Formulation is committed to the formulation development and characterization services for physical and chemical targeting nanoformulations including magnetic targeting nanoformulations, heat-sensitive nanoformulations, pH-sensitive nanoformulations, etc. Taking preparation of magnetic targeting nanoformulations as an example, we combine magnetic materials and drugs through appropriate carriers to prepare magnetic oriented systems, covering magnetic microspheres, magnetic nanoparticles, magnetic liposomes, etc.

Our Analytical Capabilities for Targeting Nanoformulations

We can also provide our clients with in vitro and in vivo evaluation services for targeting nanoformulations.

Why Choose Us to Develop Targeting Nanoformulations?

• Our core technical team, as a strong and elite team of experts, has professional nanomedicine knowledge and rich experience in targeting nanoformulation development.
• With the help of a variety of advanced instruments and equipment, we are good at developing different targeting nanoformulations including passive targeting nanoformulations, active targeting nanoformulations, physical and chemical targeting nanoformulations.
• We can respond immediately and quickly to your target nanoformulation development needs and also offer in vitro and in vivo evaluation services for targeting nanoformulations.

Published Data

Targeting nanoformulations have the characteristics of localized concentration, controlled drug release, non-toxic and biodegradable, and are widely used in the field of tumor treatment. CD Formulation, as the world's leading pharmaceutical R&D company, has rich experience in targeting nanoformulation development covering passive targeting nanoformulations, active targeting nanoformulations, and physical and chemical targeting nanoformulations. If you are interested in our services, please do not hesitate to contact us for in-depth communication and exploring.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.