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Nanocapsule Development for Nanomedicine

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Nanocapsules are microcontainers made of natural or synthetic polymer materials. By surface treatment of materials, nanocapsules can protect materials from environmental influences, shield taste, color, odor, isolate active ingredients, etc. Due to the targeting and sustained-release properties of nanocapsules, they have been widely used in various industries and play a huge role in the fields of medicine, food and cosmetics. CD Formulation can provide our clients with nanocapsule development services for nanomedicines to meet the different requirements using our advanced nanocapsule preparation methods. Our highly qualified nanoformulation development team can design and explore nanocapsule fabrication techniques, thus promoting research of nanocapsules for nanomedicine.

Advantages of Nanocapsule as Drug Delivery System

Nanocapsules use natural or synthetic polymer encapsulation materials to wrap solid, liquid or even gaseous core materials to form microcapsules with a diameter of 1 to 1000 nm. Nanocapsules are formed from shell-like wall coverings containing liquid contents, nanocapsules walls are composed of biodegradable polymers, often producing particles or self-assembly of amphiphilic polymer molecules at spherical interfaces. APIs are dissolved, entrapped, or encapsulated within the solid matrix of such particles of colloidal particles.

Fig.1 Structure of drug loading nanocapsule.Fig.1 Structure of nanocapsule. (Deepika Purohit, et al. 2023)

Nanocapsules, as multi-phase functional materials, have small particle size and are easy to disperse and suspend in water to form a clear and transparent colloidal solution. Here are advantages of nanocapsules as follows:

  • Minimization of the drug discomfort at the place of administration.
  • High loading dose.
  • Enhance bioavailability of the pharmaceutical active ingredient.
  • Have a greater defense against deterioration under the storage conditions.
  • Effectively control the sustained release of the active ingredient.
  • Utilization for different administration routes such as oral, nasal, parenteral, intraocular, etc.

Explore Our Nanocapsule Preparation Methods

Nanocapsule technology mainly uses nanocomposite materials, nanoemulsification, and nanostructure technology to encapsulate biologically active substances in nanoscale spaces and release functional ingredients under the action of specific environmental initiators. We are committed to the research of nanocapsule preparation technology for many years. We can provide our customers with nanocapsule preparation technology based on chemical methods, physicochemical methods, physical methods, etc.

Fig.2 Nanocapsule fabrication methods.Fig.2 Preparation techniques of nanocapsules. (CD Formulation)

Our Analytical Capabilities for Nanocapsules

The important physical and chemical properties of the individual capsules become crucial characteristics, such as capsule radius distribution, the capsule surface, the thickness and the permeability of the capsule membrane and capsule decomposition. We can provide you with the following characterization services for nanocapsules.

  • Physical and Chemical Properties (capsule radius distribution, capsule surface, thickness and permeability of the capsule membrane and capsule decomposition)
  • Particle Size
  • Surface Morphology
  • Zeta potential
  • Drug Content
  • In Vitro Drug Release

Why Choose Us to Develop Nanocapsules?

  • We utilize nanocapsule technology to encapsulate active pharmaceutical ingredients, which not only increases drug solubility and bioavailability but also changes the drug's distribution in the body to achieve targeted drug delivery.
  • Relying on our advanced instruments and equipment, we are highly focused on the exploration and research of nanocapsule preparation technology, including emulsion polymerization, interfacial polymerization, LBL self-assembly, Nanoprecipitation, SCF, etc.
  • We can also provide a quick response to your requirements for our analysis and characterization services for nanocapsules immediately, including capsule radius distribution, capsule surface, particle size, zeta potential, etc.
  • All experiments are signed confidentiality agreements, focusing on protecting customer privacy.

Published Data

Technology: Synthesis technology of glutathione (GSH)-cleavable covalently cross-linked polymer coatings (nanocapsules)

Journal: Nature Nanotechnology

IF: 38.3

Published: 2019

Results:

The authors report the design of customizable synthetic nanoparticles for the delivery of Cas9 nuclease and single guide RNA (sgRNA), enabling stoichiometric control of CRISPR components and limiting possible safety concerns in vivo. The authors also describe the synthesis of a thin glutathione (GSH)-cleavable covalently cross-linked polymer coating, termed nanocapsules.

The synthesis of nanocapsules was shown in Fig.3.

Fig.3 Nanocapsules synthesis process.Fig.3 Design, synthesis and optimization of nanocapsules. (Guojun Chen, et al. 2019)

CD Formulation, a prominent company in the nanomedicine field, has been dedicated to advancing nanocapsule development for many years. If you have a requirement about our services, please do not hesitate to contact us.

References

  1. Deepika Purohit, Pawan Jalwal, Deeksha Manchanda, et al. Nanocapsules: An Emerging Drug Delivery System. Recent Patents on Nanotechnology.2023, 17, 190-207.
  2. Guojun Chen, Amr A. Abdeen, Yuyuan Wang, et al. A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing. Nature Nanotechnology. 2019, 14, 974-980.
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As a specialized brand under CD Formulation, we utilize an advanced nanotechnology platform to provide exceptional support in the creation and characterization of nanomedical solutions.

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