Nucleic acid drug carriers are a class of technology platforms used to transport and deliver nucleic acid drugs, playing a crucial role in the field of nucleic acid therapy. As a high-tech company specializing in the development of nucleic acid drug delivery carriers, CD Formulation possesses strong R&D capabilities and extensive technical expertise. Our professional team is proficient in material chemistry, formulation technology, biological evaluation, and more, enabling us to offer comprehensive services for the development of nucleic acid carriers.

Why Develop Nucleic Acid Drug Delivery Carriers?

The primary objective of nucleic acid delivery vector development is to address the challenges of bioavailability and targeting of nucleic acid drugs in vivo. Naked nucleic acid molecules are easily degraded by enzymes in the organism and struggle to penetrate the cell membrane to access the target cell. Therefore, the development of efficient delivery carriers is crucial. Delivery carriers can encapsulate nucleic acid drugs, preventing their degradation by nucleases in the body and enhancing their stability. Additionally, carriers facilitate the transportation of nucleic acid drugs across bodily barriers to the disease site, thereby enhancing precision treatment. The use of carriers also helps prevent nonspecific binding to proteins in the body and aids in achieving lysosomal escape in the cell, ultimately improving the efficacy of nucleic acid drug therapy.

Fig.1 Different types of nucleic acid delivery carriers. (CD Formulation)

Characterization of Nucleic Acid Delivery Carriers

The ideal drug delivery system should have the following characteristics.

• Good biocompatibility, without triggering an immune response.
• The ability to circulate in the bloodstream for long periods of time without degradation by nucleases.
• Strong targeting and specificity, with the ability to concentrate at the site of the disease.
• High cell permeability facilitates cellular uptake.

Explore Our Nucleic Acid Delivery Carriers Development Services

CD Formulation, a company with years of experience in nucleic acid delivery system development, specializes in the development of drug delivery carriers. By integrating multiple advanced technology platforms, we have achieved significant results in improving delivery efficiency, safety, and specificity. We are committed to driving innovation and contributing to the success of your nucleic acid drug discovery program. Presently, we provide our customers with the development of various types of delivery carriers, such as conjugates, liposomes, nanoparticles, polymers, proteins...

Our Nucleic Acid Carriers Technology Platform

CD Formulation offers nucleic acid delivery technologies that enable efficient in vitro delivery of encoded gene editing proteins, including delivery to primary cells, insertion of exogenous DNA sequences into defined genomic locations, and efficient in vivo delivery of nucleic acids to the brain, eyes, skin, and lungs. These technology platforms provide crucial technical support for the development and application of nucleic acid drugs. We can select the appropriate carrier technology to optimize drug performance according to the specific needs of our customers.

Our Workflow for Nucleic Acid Carriers Development

Fig.2 Flow chart of nucleic acid delivery development. (CD Formulation)

Material Screening

This process involves evaluating the properties of various natural and synthetic polymers and selecting suitable base materials such as liposomes, polymers, and inorganic nanoparticles.

Carrier Structure Optimization

Subsequently, the selected carrier material is designed with a rational structure and composition, including factors such as size, surface charge, and affinity groups.

Preparation Process Establishment

Establishment of suitable carrier preparation processes, such as emulsification, self-assembly, centrifugation, etc., is essential to ensure the reproducibility and controllability of the preparation process.

Performance Evaluation and Characterization

Various characterization methods, such as dynamic light scattering, potentiometry, electron microscopy, etc., are used to comprehensively evaluate the physical and chemical properties of the carriers.

Process Optimization and Scale-Up

Based on the results of the preliminary evaluation, optimize and improve the formulation and preparation process of the carriers.

Why Choose Us for Nucleic Acid Carriers Development?

• Our comprehensive technology platform support includes liposomal, polymer, inorganic, viral, and other nucleic acid carrier technology platforms.
• Designing and optimizing a range of innovative delivery carriers, such as couplers, liposomes, polymers, peptides, etc., is crucial to ensure the successful implementation of various nucleic acid drug delivery system projects.
• We have a comprehensive performance evaluation that covers the physical and chemical properties, biocompatibility, and delivery effects of the carriers.
• Our team members have over 10 years of experience in developing nucleic acid drug carriers, with expertise in material chemistry, formulation processes, biological evaluation, and other related areas.

Published Data

CD Formulation has extensive experience in nucleic acid carrier research and development and can offer customers comprehensive technical support from the laboratory to industrialization. If you have any requirements, please contact us, and let's collaborate to enhance the development of superior nucleic acid drug carriers.