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Protein Carrier Development

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At CD Formulation, we specialize in the development of protein carriers tailored for the delivery of nucleic acid therapies. Our experts are committed to advancing cutting-edge carrier systems that improve the efficiency and stability of these nucleic acid drug deliveries.

Why Develop Protein Carriers?

Proteins are known for their excellent biocompatibility, ability to degrade naturally, and low toxicity levels. Their amphiphilic nature enables interactions with solvents and certain therapeutic compounds like DNA and RNA, making them ideal candidates for nucleic acid transport. A range of proteins, including gelatin, albumin, silk protein, elastin, and zein, can be effectively employed for the transportation of nucleic acids.

Fig.1 Illustration of proteins functioning as carriers for nucleic acids. Fig.1 Schematic diagram of proteins as nucleic acid carriers. (CD Formulation)

Explore Our Protein Carrier Development Services

Albumin Carrier Development Services

Albumin is a natural transport protein in the blood. Its internal binding sites and surface active groups allow it to carry multiple molecules simultaneously and be easily modified for versatile applications.

Items	Descriptions
Bovine Serum Albumin (BSA) Carrier Development	BSA is a robust and easily purified protein frequently employed to sustain the solubility and stability of drugs. Its excellent compatibility with biological systems and minimal immune response make it a preferred choice.
Human Serum Albumin (HSA) Carrier Development	HSA carriers are utilized in drug delivery by taking advantage of their inherent features, such as strong binding capabilities and robust stability. They can be tailored according to specific client needs to support the delivery of various nucleic acid drugs.

Zein Carrier Development

Zein, found in corn seeds, is a naturally occurring storage protein known for its distinct hydrophobic characteristics. These properties make it a promising option for transporting nucleic acids, as it can effectively enclose and shield these molecules, enabling stable and prolonged delivery.

Ferritin Carrier Development

With a unique cage-like structure, ferritin efficiently loads and protects nucleic acid drugs. Modified to enhance positive charge on the inner surface, this carrier improves loading efficiency, reduces immunogenicity, and offers tumor-targeting capabilities with good biocompatibility.

Our Solutions for Protein Carrier Development Services

CD Formulation's protein carrier solutions include multiple characterization analyses to evaluate their physical and chemical properties and performance.

Items	Descriptions
Particle Size Analysis	Using dynamic light scattering (DLS) to measure the size distribution of carriers helps understand protein carrier stability.
Morphological Analysis	Use TEM or SEM to observe carrier morphology and structure for characteristic information.
Chemical Composition Analysis	Analyze the chemical composition and structural features via NMR, IR, UV-Vis technologies.
Thermogravimetric Analysis (TGA)	Assess carrier thermal stability and transition properties.
Encapsulation Efficiency Measurement	Use HPLC or GC to determine the carrier's drug-loading capacity and encapsulation efficiency.

Our Workflow of Protein Carrier Development

Fig.2 Development process of protein-based carriers depicted in a flowchart. Fig.2 Flow chart of protein carrier development. (CD Formulation)

Carrier Design

Design protein carriers according to the nucleic acid drug properties and target cell types.

Carrier Production

Produce designed protein carriers using biotechnological methods.

Carrier Modification

Modify carriers chemically or biologically to enhance delivery efficiency and targeting.

Sampling and Analysis

Characterize carrier morphology and size using electron microscopy and dynamic light scattering to ensure compliance with design standards.

Stability Testing

Evaluate carrier stability under various storage conditions to ensure effective application life.

Our Technology Platforms

Our protein carrier development involves multiple analytical and testing platforms to ensure the stability, purity, activity, and safety of the protein.

Our Advantages of Protein Carrier Development

Protein carriers, being made from natural biomaterials, have excellent biocompatibility and reduce potential irritation.
Protein carriers can be diversified in structure and function through genetic engineering or chemical modifications to meet different delivery requirements.
Protein structures possess inherent precision and complexity, offering design flexibility to enhance drug stability and transmission efficiency.
Structural modifications can achieve targeted drug release, improving effectiveness while reducing side effects.
Using biotechnology, protein carriers can be efficiently produced in bioreactors and easily purified through standard bioseparation techniques.

Publication Data

Technology: Development of Protein Carriers - Utilizing Drug Delivery System Platforms

Journal: Pharmaceutics

IF: 6.525

Published: 2024

Results:

Proteins, being natural biomolecules, present distinct benefits like safety, compatibility with biological systems, and the ability to decompose naturally, positioning them as excellent substitutes for artificial polymers. Moreover, carriers made from proteins such as gelatin, albumin, collagen, gliadin, and silk proteins demonstrate enhanced stability in physiological environments and facilitate the regulated and prolonged release of medications for increased effectiveness.

Fig.3 Benefits of utilizing nanoparticles derived from proteins in drug delivery systems. Fig.3 Advantages in the adoption of protein-based nanoparticles as drug delivery systems. (Ferraro C, et al., 2024)

CD Formulation's professional team uses advanced technology and rich experience to provide customized solutions. Feel free to contact us for more information about our services and how we can assist your project.

References

Ferraro C, Dattilo M, Patitucci F, et al. Exploring Protein-Based Carriers in Drug Delivery: A Review. Pharmaceutics. 2024, 16(9): 1172.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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