Services

Start Your Project Now!

Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.

Here's how you can reach us...

Tel:
Email:

Peptide-based Carriers Development

Inquiry

CD Formulation is committed to the development of innovative peptide carriers for precise drug delivery systems. These carriers demonstrate vast potential in the biotechnology sector, providing new avenues for the transport of complex molecules, optimizing delivery efficiency, and enhancing safety.

About Peptides as Drug Delivery Carriers

Peptides are commonly occurring natural polymers, generally composed of multiple amino acids, capable of forming secondary structures (α-helix, β-sheet) via hydrogen bonds. They are easily synthesized through solid-phase methods. Peptides offer biological activity with advantages such as easy metabolism, low immunogenicity, and minimal side effects. As components of emerging drug delivery systems, they exhibit high biological activity. Their side chains can carry various active functional groups (carboxyl, hydroxyl, amino, and thiol groups) for diverse chemical modifications, facilitating the functionality of the drug delivery systems.

Fig.1 Benefits of peptide-based delivery systems. Fig.1 Advantages of peptides as drug delivery systems. (CD Formulation)

Explore Our Peptide Carrier Development Services

Cell-Penetrating Peptide Carriers Development

Cell-penetrating peptides (CPPs) are a class of oligopeptides with strong membrane activity. They simplify and increase the flexibility of nucleic acid delivery vector design, suitable for various modifications. CPPs can directly complex with nucleic acid drugs through electrostatic and hydrogen bond interactions. They can also be chemically conjugated with nucleic acid drugs or modified on other delivery systems' surfaces to enhance cellular uptake and transfection efficiency.

Multifunctional Design of Peptide Carriers

Items	Descriptions
Branched Peptide Carriers	As gene delivery vectors, branched peptides offer multi-arm modification sites conducive to multifunctionalization, designed into Y-shaped or dendritic structures to enlarge interaction areas with nucleic acid drugs and cell membranes, thereby enhancing nucleic acid loading and cellular entry efficiency.
Membrane-Affinity Peptide Carriers	By incorporating basic amino acids or side chain functional groups prone to forming hydrogen bonds, the carrier's affinity with cell membranes is improved.
Self-Crosslinking Peptide Carriers	Introducing cysteine into peptide sequences can add special functionalities by forming disulfide bonds, creating cyclic peptide structures within, inter-molecular crosslinking to encapsulate drugs, or complexing with other components like nucleic acid drugs for stable nanocomposite preparations.
Endosomal Escape Peptide Carriers	Histidine's protonation in acidic endosomal environments can trigger swelling or rupture, aiding nucleic acid escape when included in peptide sequences.

Characterization of Peptide Carriers

Analysis	Descriptions
Physicochemical Property Analysis	Analyze the basic physicochemical properties, such as molecular weight, morphology, and aggregation state.
Binding Efficiency Analysis	Evaluate the carrier's binding efficiency and stability with nucleic acids to ensure effective loading capacity.
Size and Morphology Analysis	Measurement of carrier size and shape in solution, typically using dynamic light scattering.
Biocompatibility Testing	Test the biocompatibility of carriers to ensure safety within biological systems.

Our Workflow of Peptide Carrier Development

Fig.2 Diagram outlining peptide carrier progression. Fig.2 Flow chart of peptide carrier development. (CD Formulation)

Needs Analysis - Determine the type of nucleic acid and its delivery objectives, specifying carrier characteristics and performance requirements.
Peptide Design and Synthesis - Design appropriate peptide sequences, synthesize and optimize structures to enhance nucleic acid binding and cellular uptake efficiency.
Complex Construction - Combine peptides with nucleic acid drugs to form stable complexes, optimize preparation conditions to boost delivery effectiveness.
Function Evaluation - Evaluate delivery efficiency and biological activity in cell experiments, analyze effects on target gene expression to validate application potential.

Our Technology Platforms

DLS Platform	Peptide Nanoparticles Platforms
The platform is used for measuring the size distribution of nanoparticles to assess stability and uniformity.	Our peptide nanomaterials drug delivery platform offers efficient, safe, and controlled drug delivery solutions.

Our Advantages of Peptide Carrier Development

Peptide carriers enhance the speed and precision of material transport through optimized design.
Utilizing advanced targeting technology, peptide carriers precisely deliver materials to predetermined locations, maximizing their potential effects.
The selection of high-quality materials ensures the safety of peptide carriers, minimizing unnecessary reactions.
Production of peptide carriers can be adjusted according to needs, flexibly meeting applications across various fields.

Publication Data

Technology: Development of peptide-based drug delivery platforms

Journal: Medicina

IF: 1.3

Published: 2021

Results:

Compared to synthetic systems, peptide delivery systems offer several advantages such as better biocompatibility, improved biochemical and biophysical properties, and non-toxicity. These systems can be manipulated through solid-phase synthesis and purification to control molecular weight. Peptide delivery platforms can serve as peptide-drug conjugates, injectable biodegradable particles, and reservoirs for delivering small molecular substances (500 Da). This article explores controlled delivery systems that efficiently convey anticancer compounds, facilitating recovery without significant side effects. Additionally, it reviews cell-penetrating peptides as targeting agents along with their molecular mechanisms, as well as stimuli-responsive peptides (enzyme-responsive and pH-responsive) and peptide-based self-assembling scaffolds.

Fig.3 Drug delivery via peptide carriers. Fig.3 Peptide-based drug delivery systems. (Berillo D, et al., 2021)

If you are interested in delving deeper into our peptide carrier technology or wish to explore collaboration opportunities, please contact us. Our team is ready to provide support and customized solutions tailored to your needs.

References

Berillo D, Yeskendir A, Zharkinbekov Z, et al. Peptide-based drug delivery systems. Medicina. 2021, 57(11): 1209.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

Related Services