CD Formulation excels in offering specialized VLPs development services to optimize the delivery of nucleic acid therapies. Leveraging vast industry expertise and advanced technologies, we craft bespoke VLPs designed for the secure and stable transport of diverse nucleic acid medications. Our dedicated team ensures adherence to strict quality benchmarks while adapting to unique client requirements, facilitating the transition of innovative treatments from research to real-world application.
Virus-like particles (VLPs) are large particles assembled from one or several structural proteins of various viruses, without viral nucleic acid, and cannot replicate autonomously, making them advantageous in terms of biosafety. Their nanoscale structure and modifiability confer excellent intracellular transport capabilities and targeted delivery potential. By adjusting characteristics such as size and surface charge, VLPs can enhance the stability and delivery efficiency of nucleic acid drugs, meeting the needs of modern biotechnology applications.
Fig.1 Schematic diagram of virus-like particles as nucleic acid carriers. (CD Formulation)
Items | Descriptions |
---|---|
Size Specification | Designing VLPs requires ensuring their size ranges between 10-200 nanometers to facilitate effective biological transportation. |
Structural Selection | The design must ensure high structural stability to adapt to various biological environments. |
Surface Optimization | Design modifications to surface characteristics should improve targeting capability and intracellular uptake efficiency. |
Morphological Design | Focus on the diversity of geometric shapes to ensure assembly into icosahedral or rod-like structures. |
Process Selection | Choose suitable expression systems and manufacturing processes to ensure quality and yield. |
CD Formulation demonstrates exceptional capability in the continuous production of VLPs, employing advanced technological means to significantly enhance production efficiency. By adopting innovative methods, we optimize production processes, achieving improvements in product quality consistency and efficiency. This progress has led to remarkable growth in the biopharmaceutical manufacturing field, ensuring that we provide clients with high-quality and efficient production solutions.
Items | Descriptions |
---|---|
Dynamic Light Scattering (DLS) Analysis | The analysis relies on the natural movement characteristics of particles in solution to determine their size and other physical properties. |
Multi-Scale Laser Diffraction Evaluation | We provide comprehensive characterization of VLPs by analyzing particle size distribution across different populations, revealing potential multiple particle groups within samples and aiding in product development, quality monitoring, and material optimization. |
In developing VLPs, quality control is vital to ensure consistent product quality and compliance with high standards. By implementing Quality by Design (QbD) methodology, we define product quality targets through scientific analysis and risk management from the outset, continuously evaluating and adjusting throughout the process. Establishing a reliable design space allows our R&D team to adjust process conditions flexibly to accommodate production changes while ensuring product quality and stability.
Fig.2 Flow chart of VLPs development. (CD Formulation)
Communicate with clients to understand their specific needs and project vision, laying the foundation for development work.
We develop customized VLP designs that meet specific nucleic acid drug delivery requirements.
We synthesize and test carriers in laboratory settings to ensure effectiveness and reliability in vitro.
Achieve large-scale preparation of carriers and conduct in-depth performance testing to ensure consistency.
We provide ongoing support and optimization suggestions to assist clients in smoothly transitioning to practical application.
We leverage a diverse range of technological platforms to analyze and verify the characteristics and performance of VLPs used for nucleic acid drug delivery.
Platforms | Descriptions |
---|---|
DLS Platform | The platform is applied to measure particle size distribution and aggregation states, aiding in evaluating uniformity and stability. |
Gel Electrophoresis Platform | The platform is used to determine encapsulation efficiency of nucleic acid drugs within particles, providing quantitative data with fluorescence tagging techniques. |
HPLC and MS Platforms | We can analyze in vivo metabolic pathways and evaluate the stability and distribution pattern of drugs within biological systems. |
Technology: Vaccine development utilizing virus-like particles (VLPs)
Journal: Health Sciences Review
IF: -
Published: 2023
Results:
Considering the evolving consequences of SARS-CoV-2, the article discusses the potential role of VLPs in the development of highly effective and reliable COVID-19 vaccines. In addition, the authors explain how VLPs can generate effective and durable immune responses and the recent use of VLPs in clinical trials. Furthermore, the authors highlight the limitations of VLPs, as well as possible solutions and future directions to overcome these limitations.
Fig.3 A range of different approaches to develop vaccines against the COVID-19. (Dhawan M, et al., 2023)
CD Formulation, specializing in virus-like particles development for nucleic acid therapeutic formulation, welcomes you to reach out to our skilled team for more detailed information and tailored service solutions, no matter the stage of your project. We are committed to providing full support from the initial concept design through to final implementation, aiding you in achieving your project goals.
References