Bio-MOFs Development Services for Nucleic Acid Therapeutic Formulation

CD Formulation specializes in providing innovative Bio-MOFs carrier development services for constructing nucleic acid drug delivery systems. Leveraging cutting-edge materials science and nanotechnology, our team is dedicated to exploring and developing customized solutions that meet our clients' needs.

Why Choose Bio-metal-organic Frameworks (Bio-MOFs) as Carriers for Nucleic Acid Drug Delivery?

Bio-MOFs are 3D structures created from biocompatible metal ions and organic linkers via coordination bonds. They are seen as excellent nanodrug carriers due to their precise architecture, large surface areas, tunable pores, and ease of chemical modification. Incorporating nucleic acids into Bio-MOF nanocarriers can prevent degradation and accelerate cellular uptake. Additionally, modifying the surfaces of MOFs nanoparticles with nucleic acids can enhance colloidal stability through steric hindrance and electrostatic repulsion. Currently, MOFs are studied for the delivery or controlled release of DNA, small interfering RNA (siRNA), and aptamers.

Fig.1 Schematic diagram of Bio-MOFs coated nucleic acid. (CD Formulation)

Explore Our Bio-MOFs Development Services

Our Customers can select appropriate Bio-MOFs based on the nucleic acid drug to be delivered. Various types of MOFs can be chosen or modified to meet diverse delivery needs. Additionally, the loading method can be selected according to the properties of the nucleic acid drugs.

Considerations for Toxicity and Biocompatibility

MOFs' biocompatibility is significantly influenced by the toxicity of the organic ligands used. Therefore, selecting low-toxicity or non-toxic organic ligands is crucial during Bio-MOFs synthesis.

Synthesis of MOFs

Choosing suitable synthesis methods helps control the morphology, porosity, and crystallinity of the resulting product. Common synthesis methods include hydrothermal, ultrasonic, microwave-assisted, mechanochemical, and electrochemical methods.

MOFs Loading with Nucleic Acid Drugs

We offer multiple methods for loading nucleic acid drugs, including impregnation, co-crystallization, and click chemistry.

Characterization Services for Bio-MOFs Coated with Nucleic Acid Drugs

Workflow of Bio-MOFs Development in Nucleic Acid Drug Delivery

Fig.2 Flow chart of Bio-MOFs development. (CD Formulation)

• Material Design and Synthesis

The first step involves designing biocompatible metal-organic framework materials capable of binding and protecting nucleic acid molecules. The synthesis process must ensure that the MOFs' porosity and chemical properties are suitable for nucleic acid loading.

• Nucleic Acid and MOF Integration

Following synthesis, the next step is introducing nucleic acid molecules into the MOF structure. This can be achieved through various MOF nucleic acid loading methods.

• Characterization and Analysis

Once the nucleic acids are incorporated into the MOF, various characterization methods are used to verify the integration's effectiveness, including XRD, FTIR, and CD.

• Functional Testing of the Delivery System

Evaluating the stability of the MOF carrier in biological environments and the controllability of nucleic acid release.

• Safety Assessment

Finally, conducting a series of biocompatibility and toxicity tests ensures the safety of Bio-MOFs within biological systems.

Our Advantages of Bio-MOFs Development Services

• Bio-MOFs, with their highly porous architecture, efficiently encapsulate nucleic acid drugs. The pore sizes can be tailored to fit various nucleic acid molecule dimensions.
• Functionalizing MOFs structures enables controlled release at target locations, enhancing delivery precision and efficiency.
• Bio-MOFs are typically composed of biocompatible organic ligands and metal ions, lowering toxicity and immune responses, making them safer for in vivo environments.
• The unique net structure of MOFs provides excellent chemical and thermal stability, ensuring that nucleic acid drugs remain unaffected by external environmental degradation during transport.

Publication Data

CD Formulation strives for excellence in research and development capabilities and maintain a stringent quality control system, ensuring you experience seamless and attentive collaboration throughout the development process. Please contact us, we aim to provide robust support for your innovative projects.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.