Exosome Carrier Development

CD Formulation is dedicated to the creation of innovative exosome carriers, offering advanced platforms to facilitate efficient nucleic acid delivery. Utilizing cutting-edge technology and customized solutions, projects are tailored to precisely meet client needs, establishing a solid foundation for subsequent research and applications.

Why Choose Exosomes as Drug Delivery Carriers?

Exosomes, tiny vesicles released by cells, range from 30-150 nm in size and are present in body fluids like blood and saliva. They serve as natural carriers, preserving the bioactivity of their contents, and are known for their minimal immune response and high safety profile. Through genetic and chemical modifications, their targeting capabilities can be further enhanced. Exosomes circulate through all body compartments and hold significant potential for delivering non-hepatic-targeting nucleic acids.

Fig.1 General representation of the exosome structure. (Jan A T, et al., 2021)

Explore Our Exosome Carrier Development Services

CD Formulation specializes in developing exosome carriers to optimize nucleic acid delivery systems. By improving exosome extraction and purification techniques, this service aims to enhance intracellular transport efficiency of nucleic acids. This approach combines advanced biotechnology with tailored strategies, striving for greater stability and biocompatibility in carrier design, providing robust support for relevant research.

Exosome Isolation

To enhance exosome yield and quality, various isolation techniques have been refined to ensure consistency with exosome reagents. Assessing the purity of exosome samples is crucial before application in clinical contexts, as contaminants might lead to unintended effects. Current isolation methods include differential/ultracentrifugation, filtration, size-exclusion chromatography, immunoaffinity capture, and polymer precipitation.

Exosome Characterization

After isolation, exosomes undergo a series of characterizations to confirm their identity. The characterization process usually involves analyzing physical features such as size distribution and concentration using techniques like Dynamic Light Scattering (DLS) and Nanoparticle Tracking Analysis (NTA). Additionally, morphological observation via TEM and SEM further verifies the typical vesicular structure of exosomes.

Workflow of Exosome Carrier Development

Fig.2 Flow chart of exosome carrier development. (CD Formulation)

• Exosome Extraction

Exosomes are extracted from suitable biological samples using techniques like centrifugation and ultrafiltration for initial separation.

• Exosome Purification

Further purification is done via gradient centrifugation or affinity chromatography to enhance exosome purity and quality.

• Nucleic Acid Loading

Target nucleic acids (e.g., mRNA, miRNA) are combined with purified exosomes, optimizing loading conditions to improve delivery efficiency.

• Characterization Analysis

Prepared exosome carriers undergo characterization, including size, surface markers, and nucleic acid content, to ensure compliance with research requirements.

Our Technology Platforms

Our Advantages of Exosome Carrier Development Services

• As a professional provider of exosome carrier development, we possess extensive experience in exosomal RNA projects, delivering high-quality services to our clients.
• We have professional detection platforms to meet diverse exosomal RNA analysis needs, ensuring data accuracy and reliability.
• We offer multiple exosomal RNA research solutions, covering different types like exosomal mRNA, lncRNA, miRNA, and circRNA, catering to various research needs.
• Our bioinformatics team has deep expertise, providing clients with detailed data analysis services to facilitate comprehensive research progress.

Publication Data

CD Formulation boasts strong technical service capabilities and a professional marketing and after-sales service team. In the future, we will continue adhering to the spirit of endless progress and advancement, keeping pace with life sciences industry trends, providing more outstanding products and quality services to customers. If you are interested in our services and products, please feel free to contact us.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.