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Nanoformulation Development

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Nanoformulations are mainly made of nanocarriers that bind drugs to the carrier surface through electrostatic adsorption, covalent or non-covalent connection, or directly wrap the drug inside the carrier. With the advantages of improving the stability of drugs, prolonging the circulation time in the body, increasing safety, and enabling targeted delivery, nanoformulations show great potential in improving the tissue distribution of drugs and thus increasing bioavailability. CD Formulation has been committed to nanoformulation development for many years, assisting researchers or companies from various countries in the formulation development, process optimization, quality control and commercial manufacturing of nanoformulations.

Therapeutic Fields of Nanoformulation

Nanoformulations refer to a new type of pharmaceutical formulations developed using nanocarrier technology, are widely used in therapeutic or diagnostic applications. In particular, nanoformulations have great potential in multiple therapeutic fields such as radiation therapy, chemotherapy, immunotherapy, nucleic acid therapeutics, postoperative medication, and photothermal therapy, etc.

Fig.1 Therapeutic fields of nanomedicines.Fig.1 Therapeutic landscape of nanomedicines. (Qiuyue Liu, et al., 2023)

Our Nanoformulation Development Services

CD Formulation, as a world-leading pharmaceutical service company integrating formulation development, process conversion and manufacturing, has accumulated many years of rich experience in nanoformulation development. We can provide our client with formulation development services for the following nanoformulations including but not limited to nanoparticle, nanosuspension, liposome, exosome, nanostructured lipid carrier, nanoemulsion, nanocrystal, polymeric micelle, nanofiber, nanocapsule, nanogel, microparticle, targeting nanoformulation, generic nanoformulation and oral nanoformulation according to the different needs of our customers.

Our Solutions for Nanoformulation Development

CD Formulation is committed to the formulation development and quality analysis for nanoformulations based on different nanocarrier delivery technologies, such as liposome technology, lipid nanoparticle technology, nanoemulsion technology, nanocrystal technology, polymeric micelle technology, etc. Our solutions for nanoformulation development include developing formulation and process, quality analysis and evaluation.

Developing Formulation and Process

  • Screening nanomaterials and synthesizing nanocarriers
  • Formulation and process studies

Quality Analysis and Evaluation

  • Characterization of nanoformulations
  • In vitro drug release
  • Non-clinical safety evaluation

Why Choose Us to Develop Nanoformulation?

  • We have established an advanced nanoformulatin R&D platform to comprehensively assist researchers in taking the transformation of nanoformulations from non-clinical research to commercial production to a new level.
  • We hold a variety of advanced instruments and equipment, and the support of the rapid nanomedicine preparation system has fully realized the seamless scale-up of nanoformulations from laboratory development to commercial production.
  • Our R&D team has active innovative thinking, rich nanomedicine expertise, and experimental research experience in nanoformulation development. They can provide a quick response to your requirements for nanoformulation development immediately.
  • We can provide nanoformulation development and various analysis services to characterize nanoformulations, to match customers' different requirements.

Published Data

Technology: Key technologies for porous carbon nanoparticles including spherical porous carbon nanoparticles (SPCN) and metal-organic framework (MOF)-derived porous carbon

Journal: Coordination Chemistry Reviews

IF: 20.6

Published: 2019

Results:

The authors introduce the main techniques for the preparation of porous carbon nanoparticles containing spherical porous carbon nanoparticles (SPCN) and metal-organic framework (MOF)-derived porous carbon, including (soft/hard) templates, self-assembly, Stöber method and hydrothermal carbonization, in particular to study the design and functionalization of spherical mesoporous carbon nanoparticles (MCN) at the molecular level. The synthesis of MOF nanoparticles (nanoMOF) via coordination modulation was then considered. Finally, key therapeutic applications of porous carbon materials in controlled drug delivery, bioimaging, and photothermal and multimodal therapies are outlined.

CD Formulation has been focused on nanoformulation development for years. If you have a requirement about our nanoformulation development services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

  1. Qiuyue Liu, Jiahui Zou, Zhongjian Chen, et al. Current research trends of nanomedicines. Acta Pharmaceutica Sinica B. 2023, 13(11):4391-4416.
  2. Yang Zhang, Lu Yang, Lu Yan, et al. Recent advances in the synthesis of spherical and nanoMOF-derived multifunctional porous carbon for nanomedicine applications. Coordination Chemistry Reviews. 2019,391,69-89.
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