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Nanotechnology for Transdermal Delivery

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Transdermal drug delivery offers a solution to the limitations of oral and injection methods by delivering drugs through the skin, bypassing first-pass metabolism. However, the skin acts as a natural barrier, making effective drug absorption a challenge. Nano-transdermal technology addresses this by using nanoparticles to enhance drug solubility and improve skin permeability. CD Formulation's advanced nanotechnology increases drug bioavailability, reduces systemic distribution, minimizes side effects, and ensures targeted delivery, supporting researchers and pharmaceutical development projects.

Introduction to Nanotechnology in Transdermal Delivery

A nanoparticle is a tiny drug carrier or particle, smaller than 1,000 nm. Its small size gives it special physical and chemical properties. CD Formulation uses several types of nanomaterials in transdermal delivery, like nanoemulsion, lipid-based nano-vesicles, lipid nanoparticles, polymer nanoparticles, and nanocrystals. These nanomaterials offer a new way to deliver drugs through the skin, using unique mechanisms for drug release and osmosis.

Fig.1 Schematic illustration of representative functional nanosystems for promoting transdermal drug delivery. (Lijun Liu, et al. 2023)

Key Advantages of Various Nanoformulations for Transdermal Systems

Types	Key Advantages
Nanoemulsion	Simple preparation process. It has a slow-release effect. Reduce drug irritation and side effects.
Lipid nanovesicles	Strong lipophilic, easy to pass through the stratum corneum. Strong elasticity and deformability, it can pass through the skin space completely. It can be loaded with both hydrophilic and lipophilic drugs.
Lipid nanoparticles	High drug loading rate. Improves drug stability. The blocking effect is strong, which is conducive to drug penetration.
Polymer nanoparticle	Improve drug stability. A drug reservoir is formed in the hair follicle for sustainable release. Targeted drug delivery can be achieved through surface modification.
Nanocrystals	It is composed of pure drugs, and the drug loading rate is close to 100%. Low stabilizer dosage, high safety. The preparation technology is mature and perfect, easy to mass production.

Our Advanced Nano-systems Fabrication Methods

Fig.2 Nano-systems fabrication methods for nano-enhanced transdermal delivery. Fig.2 Fabrication methods of nano-systems. (CD Formulation)

Our Nanoformulation Equipment Platform

Equipment	Specific Information
Nano spray dryer	The liquid material is atomized into tiny droplets through the atomizer. It is then rapidly dried into a nanoscale powder in hot air.
Chemical vapor deposition (CVD) equipment	Converts gaseous precursors to solid substances at high temperatures. Nanostructures are formed on the substrate.
Physical vapor deposition (PVD) equipment	The use of physical methods (such as evaporation, sputtering, etc.) to transform the material into a gaseous state. Nano-films or coatings are then deposited on the substrate.

Transdermal Formulations We Can Develop with Nanotechnology

Nanofiber/Microfiber Transdermal Patch Development

Nano and microfiber technologies enhance transdermal absorption, targeting drugs more effectively. This leads to the development of highly efficient treatment patches for specific diseases.

Solid Lipid Nano Transdermal Patch Development

It is designed to improve the skin permeability and stability of drugs for the development of highly efficient, low-irritant transdermal drug delivery systems.

Microemulsion/Nanoemulsion Transdermal Patch Development

Micro-emulsion and nano-emulsion technologies boost drug solubility and stability, enabling the development of highly bioavailable transdermal patches for systemic or local treatment with effective skin absorption.

Nano Gel Transdermal Patch Development

Nano gels, consisting of polymer networks with tunable sizes, excellent stability, and low toxicity, are ideal for drug delivery applications. Their ability to respond to stimuli makes them promising carriers.

Polymer Nano Transdermal Patch Development

Polymer-based controlled release systems allow the development of nanoscale transdermal patches that deliver drugs steadily, improving transdermal efficiency and providing long-lasting treatment for various skin conditions.

Vesicle Nano Transdermal Patch Development

Using the special properties of the vesicle structure, we can develop transdermal patches that can carry and deliver drugs effectively, enhancing skin permeability and bioavailability.

Liposome Transdermal Patch Development

Liposomes encapsulate active ingredients in lipid bilayers. Used in transdermal patches, they enhance drug stability, particularly for sensitive compounds.

Ethosomes Transdermal Patch Development

Ethosomes, with their small size and ethanol-enhanced flexibility, overcome the skin's barrier, delivering both hydrophilic and lipophilic drugs deeply for improved absorption.

Metal Nano Transdermal Patch Development

Using the unique properties of metal nanoparticles, transdermal patches with special functions can be developed, which may be used in fields such as promoting drug transdermal absorption, improving skin microcirculation, or cosmetic skin treatment.

Nanocrystal Transdermal Patch Development

Nano-carrier preparations like nanoemulsions and solid lipid nanoparticles have been used in skin drug delivery but face challenges like low drug loading and irritation. Nanocrystals offer high drug loading, stability, and improved skin delivery.

Why Choose CD Formulation for Nano-Enhanced Transdermal Solutions?

We have a professional research and development team. They have deep academic backgrounds and rich practical experience.
We are equipped with a range of advanced research and development equipment. These can meet the needs of every process from nanoparticle synthesis and characterization to transdermal absorption performance testing.
We have many years of research and development experience in nano transdermal technology. We have successfully developed a series of nano transdermal products with independent intellectual property rights.

Publication Data

Technology: Nanotechnology

Journal: Nanoscale Adv

IF: 4.6

Published: 2023

Results: Transdermal drug delivery is a gentle way to give medicine. Recently, functional nano-systems have shown great promise in treating skin diseases. They help drugs pass through the skin and reach effective levels in target tissues. Below is a brief look at these nano-systems. First, we'll cover the basics of transdermal delivery, like skin biology and how drugs enter the skin. Then, we'll explain the features of nano-systems that make them good for transdermal delivery. Moreover, the fabrication of various types of functional transdermal nano-systems is systematically presented. Multiple techniques for evaluating the transdermal capacities of nano-systems are illustrated.

With extensive expertise in nano-transdermal systems, we have developed a variety of nanoformulations, including lipid, solid lipid, and polymer nanoparticles. These formulations show great promise in enhancing transdermal drug delivery. For customized solutions and further assistance, feel free to contact us. Our team will respond within three working days.

References

Lijun Liu, Wenbin Zhao, et al. Functional nano-systems for transdermal drug delivery and skin therapy. Nanoscale Adv. 2023, 5, 1527.

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