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Vesicle Nano Transdermal Patch Development

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Traditional drug delivery methods, such as oral tablets and injections, often face challenges like low bioavailability, fluctuating plasma levels, and inconsistent administration. CD Formulation specializes in creating custom transdermal delivery solutions, overcoming these challenges with a more controlled, consistent, and efficient method. Our Vesicle Nano Transdermal Patch leverages nanotechnology to enhance drug delivery through the skin.

About Vesicle Nano Transdermal Patches

At the core of our transdermal patch is the utilization of vesicles—tiny, spherical structures composed of lipid bilayers. These cysts are engineered at the nanoscale to encapsulate the active pharmaceutical ingredient (API), protecting it from degradation and facilitating its controlled release into the bloodstream. Vesicles are non-ionic surfactant vesicle systems ranging in size from 100 to 2000 nanometers. The surfactants used to form vesicles are biodegradable, biocompatible, and non-immunogenic. Compared with liposomes, vesicles have higher encapsulation efficiency, better chemical stability, stronger permeability, and lower cost.

Fig.1 Illustration of nanoscale vesicle structures used in transdermal drug delivery. Fig.1 Diagrammatic representation of vesicle and particle systems. (Unnati Garg, et al. 2022)

Our Vesicle Nano Transdermal Patch Development Services

Selection of Lipid Components

We carefully select lipids such as phosphatidylcholine, cholesterol, and other amphiphilic molecules to form bilayers. Lipid choice affects vesicle size, stability, and drug release characteristics.

Hydration Method

The lipids are dissolved in an organic solvent (e.g., chloroform or ethanol) to create a lipid film. This film is then hydrated with an aqueous solution containing the drug of interest. The hydration process can be performed at an elevated temperature to encourage the formation of vesicles.

Drug Loading

During the hydration process, the drug is encapsulated within the vesicles. The encapsulation efficiency depends on factors such as the drug's solubility, vesicle composition, and preparation method. For hydrophilic drugs, the drug is trapped in the aqueous core, while hydrophobic drugs are embedded within the lipid bilayer. Our techniques ensure high encapsulation efficiency for various drug types.

Surface Modification

We enhance penetration and control release by modifying the vesicle surfaces with specific ligands or polymers, such as hydrophilic polymers, to increase stability and prolong skin absorption.

Our Method for Vesicle Stabilization

Method	Description
Surface Modification	Surface modifications, such as adding PEG (polyethylene glycol), enhance vesicle stability, prevent aggregation, and extend absorption time within the skin layers.
Lyophilization (Freeze-Drying)	We can use lyophilization to ensure long-term vesicle stability. Cryoprotectants like trehalose or sucrose are added to preserve structure during this process.

Why Choose CD Formulation?

Expertise in Nanotechnology: Our experienced team of scientists and engineers specializes in the creation and optimization of nano-sized vesicles, ensuring effective transdermal delivery of a wide range of therapeutic agents.
State-of-the-Art Manufacturing: We utilize advanced facilities to produce vesicle nano transdermal patches with precision and consistency. Our automation and quality control systems guarantee compliance with stringent standards.
Innovative Solutions: We explore personalized transdermal technologies, offering tailored solutions to researchers that enhance the effectiveness of drug delivery systems.

Published Data

Technology: Technology for Vesicle Nano Transdermal Patch

Journal: Adv Pharm Bull

IF: 3.1

Published: 2022

Results: Transdermal delivery over the past decade has become the field of interest for drug delivery due to its various advantages such as no first-pass metabolism, increased drug bioavailability, and easy administration. Different vesicle systems like ethosomes, liposomes, niosomes, and transferosomes along with particle systems like lipid nanoparticles, polymeric nanoparticles, carbon nanotubes, and fullerenes have been developed. These vesicles and particle systems have been developed using various easy and effective methods like cold injection method, rotary film evaporation, thin film hydration, high shear homogenization, solvent extraction method, and many more. These drug delivery systems are a very effective and feasible option for transdermal drug delivery and further developments can be made to increase their use. This article explains in detail the preparation methods and applications for these drug delivery systems.

Our Vesicle Nano Transdermal Patch exemplifies advanced transdermal drug delivery, using nanotechnology to enhance drug stability, permeability, and controlled release. For more details or to discuss your project requirements, please contact us, and our team will respond within three working days.

References

Unnati Garg , Karuna Jain. Dermal and Transdermal Drug Delivery through Vesicles and Particles: Preparation and Application. Adv Pharm Bull. 2022 Jan; 12(1): 45–57.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

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STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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