In the domain of drug delivery, recent progress has been remarkable, particularly with the emergence of Nanocrystal Transdermal Patches as a forefront innovation. These patches signify a major leap forward in the administration of medications, providing distinct benefits over conventional oral or injectable approaches. At CD Formulation, we are at the forefront of this innovation, shaping the future of pharmaceuticals with our cutting-edge nanocrystal transdermal patch technology. Our commitment is to revolutionize medication delivery, optimizing both efficacy and ease of use for researchers in the field.
Nanocarrier-based preparations, such as nanoemulsions, solid lipid nanoparticles (NPs), silicon nanoparticles, nanostructured lipid carriers, and polymerized nanoparticles, have been used for skin drug delivery. However, most NPs have the characteristics of low drug loading, limited permeability, and local skin irritation caused by heavy use of surfactants, and the carrier material may change the NPs themselves. These limitations often fail to achieve the desired therapeutic effect. Compared with these nanocrystals, nanocrystals (NCs) have the advantages of high drug loading (almost 100%), good stability, low toxicity, and simple preparation. Therefore, drug NCs are very promising in local drug delivery, because they can achieve both efficient skin delivery and durable in vivo release. They also have high drug loading capacity, low toxicity, and good stability.
Fig.1 Schematic diagram of nanocrystal transdermal patches. (Prashantkumar K. Parmar, et al. 2021)
Our nanocrystal patches can be prepared using various methods, including but not limited to the following:
Methods | Description |
---|---|
Nano Powder Technology | Directly processing raw materials into nanoscale dimensions and mixing them with auxiliary materials to form patches. |
Nanocarrier Systems | Employing nanoliposomes and polymer nanocapsules to encapsulate drugs in nanoparticles for targeted delivery and controlled release. |
High-Energy Ball Milling | Utilizing mechanical force to reduce drug particles to the nanometer scale, then mixing with other ingredients to create patches. |
Technology: Technology for Nanocrystal Transdermal Patch
Journal: Drug Discovery Today
IF: 8.2
Published: 2021
Results: The barrier function of skin and the non-optimal physicochemical properties of drugs present challenges to the skin penetration of many drugs, thus motivating the development of novel drug delivery systems. Recently, nanocrystal-based formulations have been investigated for topical drug delivery and have demonstrated improved skin penetration. This review highlights barriers in skin penetration, current techniques to enhance topical delivery, and the application of nanocrystals in conquering obstacles to topical delivery. Nanocrystals can improve delivery through the skin by mechanisms including the creation of a higher concentration gradient across skin resulting in increased passive diffusion, hair follicle targeting, formation of diffusional corona, and adhesion to skin.
Our nanocrystal transdermal patch technology is a testament to our commitment to enhancing the effectiveness and accessibility of medications, making them more user-friendly. If you have any research or development needs in this domain, please contact us without hesitation. Our team will be in touch within three working days to discuss your requirements.
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