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Polymer Nano Transdermal Patch Development

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In the dynamic field of drug delivery systems, polymer nano transdermal patches represent a significant innovation, combining polymer science and nanotechnology to enable effective administration of medications through the skin. CD Formulation provides professional services for developing polymer nano transdermal patches tailored to your specific research needs.

About Polymer Nano Transdermal Patches

The local approach is the most suitable way to deliver drugs to skin tissue to treat local skin diseases. However, the outermost layer of the skin, the stratum corneum (SC), is a major barrier. Nanotechnology-assisted interventions have been extensively studied for local administration of a variety of treatments. The number of polymer nanocarriers used for transdermal drug delivery has been increasing. Nanocarriers made from biodegradable polymers have the potential to overcome limitations associated with other lipid systems, such as lower drug loading and phase stability issues. In addition, the physicochemical properties of these polymer nanocarriers enable sustained and controlled drug release and specific targeting.

Advantages of Polymer Nano Transdermal Patches

Fig.1 Diagram illustrating the advantages of polymer nano transdermal patches, highlighting enhanced drug delivery and sustained release.Fig.1 The Advantages of Polymer Nano Transdermal Patch. (CD Formulation)

Our Polymer Nano Transdermal Patch Development Services

We specialize in providing various polymer-carriers for transdermal drug delivery, including:

Polymer Nanoparticles

These particles range from 10 to 1000 nanometers, composed of biocompatible polymers. Drugs can be dissolved, encapsulated, or attached to the polymer matrix for efficient delivery.

  • Preparation: Nano-precipitation, emulsification/solvent evaporation, and salting out methods.
  • Polymer materials: Common polymers include gelatin, chitosan, albumin, hyaluronic acid (HA), and polylactic acid (PLA).

Fig.2 Visual representation of polymeric nanoparticle synthesis methods, showing steps from preparation to final nanoparticle formation.Fig.2 The synthesis and representation of polymeric nanoparticles and polymeric micelles. (Lijun Liu, et al. 2023)

Polymer Micelles

  • Polymer micelles for transdermal drug delivery have attracted a great deal of attention in recent years. To reduce surface free energy in aqueous media, these micelles can be self-assembled from amphiphilic block copolymers at or above specific polymer concentrations (critical micelle concentrations) to form hydrophobic nuclei and hydrophilic shells. Hydrophobic nuclei contribute to drug solubility and reservoir effects, while hydrophilic shells contribute to stability. In addition, depending on the number of copolymer blocks and their arrangement in the dispersion, micellar forms such as worm-like, aversive, or lamellar forms can be formed.
  • Preparation: Polymer micelles can be generated by a variety of processes, including solvent evaporation (solution casting), self-assembly, and solid dispersion.

Dendritic Polymers

  • Dendrimers are monomolecular, monodisperse synthetic polymers (typically <15 nm) with symmetrically placed branching units that can form spherical shapes. Dendritic polymers promote drug penetration by increasing drug solubility and enhancing the distribution and diffusion of drug molecules through the skin.

Fig.3 Illustration of dendrimer and metallic nanoparticle synthesis, highlighting their role in transdermal delivery.Fig.3 The synthesis and characterization of dendrimer and metallic NPs for transdermal delivery. (Lijun Liu, et al. 2023)

Types of Patches We Can Develop

Based on our polymer nano transdermal patch development platform, we can offer you the following types of patch development services:

  • Drug Delivery Patches: For local or systemic therapeutic research applications, such as anti-inflammatory and hormone delivery.
  • Beauty and Skincare Patches: Focused on cosmetic applications, containing active ingredients like antioxidants, moisturizers, and skin-whitening agents to improve texture, reduce wrinkles, and even skin tone.
  • Other Functional Patches: Includes patches with additional benefits such as sun protection, mosquito repellent, and skin-soothing properties.

Why Choose CD Formulation?

  • We have a deep understanding of the latest trends and advancements in the field of patch technology, enabling us to develop innovative and effective products that meet the needs of our clients.
  • We have a team of skilled and experienced engineers and researchers who are dedicated to designing and manufacturing high-quality patches that are comfortable, discreet, and easy to use.
  • We have invested in advanced technology and equipment to develop high-quality and effective transdermal patches. This includes state-of-the-art manufacturing facilities and rigorous testing procedures to ensure the safety and efficacy of our products.

Published Data

Technology: Technology for Polymer Nano Transdermal Patch

Journal: Nanoscale Adv

IF: 7.233

Published: 2023

Results: Transdermal drug delivery is one of the least intrusive and patient-friendly ways for therapeutic agent administration. Recently, functional nano-systems have been demonstrated as one of the most promising strategies to treat skin diseases by improving drug penetration across the skin barrier and achieving therapeutically effective drug concentrations in the target cutaneous tissues. Here, a brief review of functional nano-systems for promoting transdermal drug delivery is presented. The fundamentals of transdermal delivery, including skin biology and penetration routes, are introduced. The characteristics of functional nano-systems for facilitating transdermal drug delivery are elucidated. Moreover, the fabrication of various types of functional transdermal nano-systems is systematically presented. Multiple techniques for evaluating the transdermal capacities of nano-systems are illustrated.

CD Formulation is committed to advancing drug delivery systems by developing cutting-edge polymer nano transdermal patches for research purposes. Contact us to discuss your project, and our team will respond within three working days.

References

  1. Lijun Liu, Wenbin Zhao, et al. Functional nano-systems for transdermal drug delivery and skin therapy. Nanoscale Adv. 2023, 5, 1527-1558.
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