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Ethosomes Transdermal Patch Development

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In the rapidly evolving landscape of drug delivery, the quest for potent, non-invasive solutions is at the heart of our innovation. CD Formulation is at the forefront of this advancement, specializing in the development of transdermal patches that employ ethosomes. These ethosomes represent a groundbreaking vesicular carrier system, engineered for optimal drug delivery efficacy in our research and development services.

About Ethosomes Transdermal Patches

The primary challenge in transdermal drug delivery is the skin's natural barrier, which is designed to protect the body from external agents. Ethosomes overcome this barrier through a combination of their small size, flexible structure, and ethanol-induced fluidization of the skin lipids. This allows them to carry both hydrophilic and lipophilic drugs deep into the skin, ensuring better absorption and bioavailability. The high ethanol content in ethosomes also enhances their ability to encapsulate a wide range of therapeutic agents, including small molecules, peptides, proteins, and even genetic material. This versatility makes ethosomes a promising carrier for a broad spectrum of treatments, from pain management to hormone replacement therapy, and even in the delivery of vaccines and gene therapies.

Fig.1 Diagram of Ethosomes demonstrating their vesicular structure and enhanced permeability. Fig.1 Proposed diagram of Ethosomes. (Poonam Verma, et al. 2021)

Characteristics of Ethosomes

Stable structure: Ethosomes have a stable vesicle structure, which can protect the stability of drugs during transmission.
High permeability: The addition of anhydrous ethanol can change the tight arrangement of lipids between keratinocytes, enhance the fluidity and permeability of the skin, and thus significantly improve the transdermal permeability of drugs.
Multi-purpose: Ethosomes can be made into a variety of dosage forms such as patches, creams, and gels, to meet different drug delivery needs.

Our Methods for Ethosome Preparation

Methods	Description
Hot Method	Dissolve the phospholipids in ethanol. Heat the mixture to a temperature between 30°C and 60°C. Slowly add the aqueous phase (water) while maintaining the temperature and stirring continuously. Continue stirring until the mixture cools down to room temperature.
Cold Method	Dissolve the phospholipids in ethanol at room temperature. Inject this ethanol-phospholipid solution into a cold aqueous phase (water) under stirring. The sudden addition causes the formation of ethosomes as the ethanol diffuses and interacts with the phospholipids.
Thin-Film Hydration Method	Dissolve the phospholipids in an organic solvent and evaporate the solvent to form a thin lipid film on the walls of a flask. Hydrate the film with an aqueous phase (water or buffer solution) under stirring. Continue stirring until the film is fully hydrated and ethosomes are formed.

Types of Patches We Can Develop

Ethosomes can be used as carriers for polar, nonpolar, and amphiphilic drugs, and deliver drugs to the deep layers of the skin. If the drugs enter the blood vessels, they can also exert systemic therapeutic effects. We can develop a variety of those transdermal patches for you:

Localized skin conditions (e.g., inflammation, fungal infections)
Neurological support (e.g., depression, Alzheimer's disease)
Systemic therapeutic effects when drugs enter the bloodstream

Why Choose CD Formulation?

Expert Team & Industry Experience: Skilled professionals offer tailored solutions for complex drug delivery needs.
Advanced Technology: Cutting-edge approaches improve drug permeability and bioavailability, maintaining technological leadership.
Comprehensive R&D Services: Full-service support from R&D to production, reducing development costs and risks for clients.

Published Data

Technology: Technology for Ethosomes Transdermal Patch

Journal: J Adv Pharm Technol Res

IF: 1.4

Published: 2021

Results: The main disadvantage of transdermal drug delivery is the poor penetration of most compounds into the human skin. The main barrier of the skin is located within its uppermost layer, the stratum corneum (SC). Several approaches have been developed to weaken this skin barrier. One of the approaches for increasing the skin penetration of drugs and many cosmetic chemicals is vesicular systems, such as liposomes and ethosomes. Ethosomes are phospholipid-based elastic nanovesicles containing a high content of ethanol (20–45%). Ethanol is an efficient permeation enhancer added to the vesicular systems to prepare elastic nanovesicles. It can interact with the polar head group region of the lipid molecules, resulting in the reduction of the melting point of the stratum corneum lipid, thereby increasing lipid fluidity and cell membrane permeability. The high flexibility of vesicular membranes from the added ethanol permits the elastic vesicles to squeeze themselves through the pores, which are much smaller than their diameters. Ethosomal systems are much more efficient in delivering substances to the skin in terms of quantity and depth than either conventional liposomes or hydroalcoholic solutions. The scope of this small review is to introduce the novel concept of ethosomes and to describe some approaches and mechanisms of stimulating topical and transdermal products with ethosomes.

CD Formulation is dedicated to pushing the boundaries of innovation, as demonstrated by our state-of-the-art manufacturing facilities and rigorous quality control measures. These ensure that our transdermal drug delivery research and development services adhere to the utmost standards of safety and efficacy. Our experts are continuously perfecting our methodologies to provide cutting-edge solutions in ethosomes-based transdermal drug delivery. If you have any needs, please do not hesitate to contact us, and our colleagues will contact you within three working days.

References

Poonam Verma, K. Pathak. Therapeutic and cosmeceutical potential of ethosomes: An overview. J Adv Pharm Technol Res. 2010; 1(3): 274–282.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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