Microemulsion/Nanoemulsion Transdermal Patch Development

At CD Formulation, we specialize in developing advanced microemulsion and nanoemulsion transdermal patches. Our services provide innovative solutions for effective and controlled drug delivery through the skin, meeting the highest standards of quality and efficacy to ensure your products excel in the market.

About Microemulsion/Nanoemulsion Transdermal Patches

Microemulsions and nanoemulsions have good skin permeability and can promote the transdermal absorption of drugs by increasing the solubility of drugs, increasing the fluidity of the stratum corneum lipid bilayer, and acting on skin hair follicles. Because of its small particle size, nanoemulsions can penetrate the skin barrier more effectively and improve the bioavailability of drugs. These technologies enhance the delivery of active pharmaceutical ingredients (APIs) through the skin, improving effects. Microemulsion and nanoemulsion transdermal patches leverage the unique properties of microemulsions and nanoemulsions to improve solubility, stability, and penetration of drugs or active compounds.

Fig.1 Permeation pathways in the skin (the stratum corneum, SC, is illustrated). (A) The transcellular route is associated with the proteins inside corneocytes. (B) The intercellular route and the appendageal route through (C) hair follicles with associated sebaceous glands (D) via sweat ducts. (Dalia S. Shaker, et al. 2019)

Advantages of Microemulsion/Nanoemulsion Transdermal Patches

Fig.2 The advantages of microemulsion/nanoemulsion transdermal patches. (CD Formulation)

• Enhanced Drug Solubility: Microemulsions improve the solubility of poorly water-soluble drugs, making them suitable for transdermal delivery.
• Improved Skin Penetration: The small droplet size facilitates better penetration through the skin, enhancing drug absorption.
• Stability: Microemulsions are more stable than conventional emulsions, contributing to longer shelf life and consistent performance of the transdermal patch.
• Controlled Release: They can provide controlled and sustained release of active ingredients, reducing the frequency of application.

Applications of Microemulsion/Nanoemulsion Transdermal Patches

Our Microemulsion/Nanoemulsion Transdermal Patch Development Services

Formulation Design and Optimization

• Emulsion Type Selection: We decide between microemulsion (typically oil-in-water) or nanoemulsion (oil-in-water or water-in-oil) based on the desired release profile and drug properties.
• Surfactant Screening: We select suitable surfactants and co-surfactants to optimize the oil-water interfacial tension and improve the stability of microemulsions.
• Particle Size Control: By adjusting the formulation ingredients and preparation process, the particle size of microemulsions/nanoemulsions is controlled within the range of 1 to 100 nm to achieve the best transdermal effect.

Preparation Process Development

• High-energy Emulsification: Use dynamic ultra-high pressure microfluidizers, ultrasonic generators, or high-pressure homogenizers to homogenize the crude emulsion to prepare nanoemulsions with uniform particle size distribution.
• Low-energy Emulsification: Use low-energy emulsification techniques such as the emulsion inversion point (EIP) method or phase inversion emulsification (PIT) method to prepare microemulsions with excellent stability.
• Process Optimization: Through repeated experiments and data analysis, the preparation process parameters are optimized to improve production efficiency and product quality.

Performance Evaluation and Testing

Why Choose CD Formulation?

• Custom Emulsion Formulation: Our team of experts collaborates closely with researchers to develop bespoke microemulsion and nanoemulsion formulations. These formulations are meticulously crafted to cater to specific research requirements, focusing on optimizing the emulsion's composition to enhance drug solubility and stability for transdermal delivery systems.
• Scalable Manufacturing: We provide scalable manufacturing solutions that are adaptable to various stages of research and development. This ensures consistent quality and performance throughout the development process, supporting researchers in bringing their transdermal technology projects to fruition.
• Product Improvement: We leverage market feedback and performance data to refine and enhance our transdermal patches. This commitment ensures that our products not only meet the current needs of researchers but also maintain high-performance standards as research and technology evolve. Our services are dedicated to supporting researchers in their quest for innovative transdermal delivery solutions.

Published Data

Microemulsion and nanoemulsion transdermal patches are advanced drug delivery systems. These patches utilize specialized emulsion technologies to improve the penetration, stability, and bioavailability of active pharmaceutical ingredients (APIs). If you have any needs, please do not hesitate to contact us, and our colleagues will contact you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.