Nano transdermal patches employ advanced nanotechnology to encapsulate drugs in nanocarriers, delivering them effectively through the skin. As a pioneer in transdermal drug delivery, CD Formulation is dedicated to the research and development of nano transdermal patches. We boast a robust scientific research team and state-of-the-art production equipment, dedicated to offering safe, efficient, and convenient solutions for research organizations worldwide.
Fig.1 Illustration of nanoparticle skin penetration pathways. Topically applied nanoparticles can penetrate the skin in one of three different ways: (1) through the appendageal route, (2) through the intracellular route, or (3) through the intercellular route. The appendageal route involves nanoparticles entering hair follicles, sweat glands, or skin furrows for either penetration to the dermis or retention for increased drug release. The intracellular route involves a direct path through the cell membrane of multiple layers of the epidermis. The intercellular route involves a more tortuous path between epidermal cells. The pathway taken likely depends on the nanoparticle size, charge, morphology, and material. (Brian C. Palmer, et al. 2016)
Nano transdermal patches contain drug-loaded nanoparticles that are designed to effectively penetrate the skin barrier. Nanoparticles can be made of a variety of materials such as lipids, polymers, or metals, and are customized to optimize drug release and skin penetration. Compared with traditional transdermal patches, nanoparticles help control and sustain the release of drugs, thereby improving bioavailability and therapeutic effects. Depending on the formulation design, they can be delivered to specific skin layers or systemic circulation in a targeted manner. Nano-sized particles have a larger surface area to volume ratio, enhancing their ability to penetrate the skin layer and deliver drugs more effectively.
Fig.2 Advantages of Nano Transdermal Patches (CD Formulation)
At CD Formulation, our nano-transdermal patch platform provides comprehensive services from drug screening, formulation design, and process development to performance testing. This integrated approach significantly shortens the R&D cycle and reduces costs for nano patch products.
Vesicles with a bilayer conformation can improve the transdermal delivery of poorly soluble and large molecular drugs.
Although the drug loading capacity is low and the release is uncontrollable, its transdermal efficiency can be improved by improving its formulation and process.
Natural polymer materials such as chitosan and synthetic polymer materials such as PLGA have good biocompatibility and multifunctionality, which can achieve precise drug delivery and long-term sustained release.
Microneedles can penetrate the stratum corneum of the skin and form tiny channels after entering the skin. Drugs enter the skin through these tiny channels, thereby achieving the effect of promoting transdermal penetration. Microneedle technology combines nanotechnology and micromachining technology to provide new solutions for transdermal drug delivery systems.
Using biodegradable materials as the matrix of nanocarriers can achieve precise drug delivery while reducing damage to human tissues and side effects.
Technology: Technology for Nano transdermal patch development
Journal: Molecules
IF: 4.927
Published: 2016
Results: Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for disease treatment and vaccination. Nanocarriers made of lipids, metals, or polymers have been successfully used to increase the penetration of drugs or vaccines, control drug release, and target drugs to specific areas of skin in vivo. Here, we review the current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases.
Nano transdermal patches have broad application prospects and development potential in the medical field due to their advantages in precise delivery, long-term stability, wide applicability, reduced side effects, improved patient experience, and innovative technology. If you have any needs, please feel free to contact us, and our colleagues will contact you within three working days.
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