Transdermal formulation, also known as the transdermal drug delivery system (TDDS), involves the absorption of drugs through the skin into systemic circulation to achieve effective blood concentrations for local or systemic therapeutic effects. It is the third-largest drug delivery route after oral administration and injection. CD Formulation, a leader in transdermal drug delivery technology, is committed to supporting the research and development of innovative transdermal formulations.

Mechanism of Transdermal Formulations

Fig. 1. Schematic representation of transdermal drug delivery mechanisms. (Delly Ramadon, et al. 2022)

The transdermal drug delivery process consists of three main steps: the release of active ingredients, penetration through the skin or mucosa, and absorption into systemic circulation. First, the active ingredient is released from the formulation and diffuses to the skin's surface. Then, it penetrates the epidermis to reach the dermis and subcutaneous tissues. Finally, it is absorbed into the bloodstream or lymphatic vessels, circulating throughout the body to exert therapeutic effects.

Advantages of Transdermal Formulations

Compared to injections and oral formulations, transdermal formulations offer the following benefits:

Fig.2 Advantages of Transdermal Formulations (CD Formulation)

Our Transdermal Formulation Development Services

• Gel Transdermal Formulation Development
• Cream Transdermal Formulation Development
• Ointment Transdermal Formulation Development
• Spray Transdermal Formulation Development
• Transdermal Patch Development
• Transdermal Microneedle Patch Development
• Nano Transdermal Patch Development
• Peptide Transdermal Formulation Development
• Protein Transdermal Formulation Development
• Nucleic Acid Transdermal Formulation Development

What Can We Offer?

Drug Screening and Evaluation

We conduct thorough evaluations of the physicochemical properties, solubility, and pharmacokinetics of drug molecules to identify candidates suitable for transdermal delivery.

Formulation Development and Optimization

We specialize in matrix selection, drug release regulation, and permeability enhancer optimization, ensuring that the prepared formulations achieve stable and effective drug delivery.

In Vitro Transdermal Performance Testing

Using advanced in vitro skin models, we evaluate the formulation's absorption, release rate, and distribution across the skin.

In Vitro Release Kinetics Studies

We analyze the drug's release rate and mechanism in different transdermal formulations to ensure controlled and sustained delivery.

Why Choose CD Formulation?

• Expert R&D Team: Our team brings years of experience in transdermal formulation, adept at addressing complex challenges.
• Technological Expertise: We excel in formulation process optimization, excipient screening, and quality control.
• State-of-the-Art Equipment: We utilize advanced instruments such as high-performance liquid chromatography, gas chromatography, and transdermal diffusion systems to conduct precise analyses.

Published Data

Transdermal drug delivery systems are safe and controllable, and combined with their advantages and characteristics, they have become a research hotspot for many scientific researchers in the pharmaceutical industry. If you have any needs, please feel free to contact us, and our colleagues will contact you within three working days.