Protein Transdermal Formulation Development

CD Formulation has a top R&D team of experts in pharmacy, chemistry, materials science, and dermatology. With deep expertise and extensive research and development experience, we carefully design and continuously optimize the formulation of protein transdermal formulations. From raw material screening, and formula adjustment to process optimization, we are committed to creating high-quality and highly stable protein transdermal formulations.

About Protein Transdermal Formulations

Protein drugs are widely used in many diseases for treatment because of their high biological activity and strong specificity. However, traditional delivery methods such as oral and injection have many limitations, such as low bioavailability and poor patient acceptance. Protein transdermal formulation is a formulation that is made of protein drugs (such as biological drugs such as peptides and proteins) through transdermal technology and is used for drug delivery on the skin surface so that drugs can enter the body through the skin to play a role. Compared with oral and injection administration, transdermal administration has the advantages of being non-invasive, avoiding the first-pass effect, maintaining constant blood concentration, and prolonging action time.

What Can We Offer?

Thanks to our platform for protein transdermal formulations development, CD Formulation offers one-stop services from raw material screening, and formulation adjustment to process optimization, which reduces the development cycle and development costs of protein transdermal formulations.

Protein modification

Chemical modification: Structural modification of proteins by introducing additional groups (such as pegylation) to improve their enzyme stability and membrane permeability.

Backbone modification: Such as cyclization strategies and amino acid substitutions to improve the stability of gastrointestinal enzymes.

Screening of transdermal accelerators

The transdermal absorption of proteins was promoted by physical methods such as ionophoresis, electroporation, and thermal ablation.

Microneedle patch technology, which forms drug transport microchannels by painlessly destroying the stratum corneum, is also an effective transdermal drug delivery method.

Preclinical assessment

Evaluation of systemic exposure and biological response through in vitro studies of skin penetration, release curve, and stability, and in vivo studies in animal models.

Workflow for Protein Transdermal Formulation Development

1. Consultation: Understanding client requirements and project goals.
2. Research & Development: Developing preliminary concepts based on scientific research.
3. Raw Material Screening: Selecting optimal ingredients for formulation.
4. Formulation Development: Designing and testing initial formulations.
5. Optimization: Refining formulas for maximum efficacy and stability.
6. Preclinical Testing: Conducting in vitro and in vivo studies.

Our Innovative Technology

We use various delivery systems to facilitate protein delivery through the skin. Including but not limited to:

Fig.1 Different application modes of microneedle technology. a Portion of the skin with solid microneedles followed by application of a drug-loaded patch; b insertion of drug-coated solid microneedles; c insertion of drug-encapsulated soluble microneedles; and d insertion of hollow microneedles for infusion of liquid formulations. (Haripriya Kalluri, et al. 2011)

• Microneedles Array: Microneedles form instantaneous microchannels in the skin that allow proteins to bypass the stratum corneum and reach deeper layers.
• Liposomes and nanoparticles: Lipid carriers can coat proteins, protect them, and facilitate their delivery through the skin.
• Hydrogel and patch systems: Hydrogels and patches sustainably release proteins, improving their bioavailability and therapeutic effectiveness.

Why Choose CD Formulation?

• We have a research and development team composed of top experts and scholars, who have deep academic attains and rich research and development experience in transdermal drug delivery.
• Through in-depth research on transdermal promotion technologies, we can develop protein transdermal formulations with higher bioavailability and lower side effects to meet the therapeutic needs of patients.
• We have introduced a series of advanced production equipment, such as high-precision mixers, automatic coating machines, vacuum dryers, etc., to ensure the quality control and stability of protein transdermal formulations in the production process.

Published Data

CD Formulation is committed to creating high-quality, highly stable protein transdermal formulations. We have advanced transdermal delivery technologies, such as liposomes, microemulsion, ion electroosmosis, electroporation, etc., which can significantly improve the efficiency of protein transdermal absorption. Nanocarrier technologies such as liposomes can not only protect proteins from degradation, but also achieve sustained release and targeted drug delivery through the skin barrier. If you have any needs, please feel free to contact us, and our colleagues will contact you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.