Transdermal Microneedle Patch Development

The development of transdermal microneedle patches has been an important research direction in the field of transdermal drug delivery systems in recent years. It combines the advantages of microneedle technology and transdermal patches to improve the transdermal absorption efficiency and therapeutic effect of drugs. CD Formulation has professional knowledge and technical accumulation in the field of transdermal microneedle patches and provides you with a variety of transdermal microneedle patch development services.

Overview of Transdermal Microneedle Patches

Fig.1 Mechanism of drug delivery by microneedle device: (1) Microneedle device with drug solution; (2) Device inserted into the skin; (3) Temporary mechanical disruption of the skin; (4) Releasing the drug in the epidermis; (5) Transport of drug to the site of action. (Tejashree Waghulea, et al. 2019)

Microneedle patches contain tiny needles hundreds of microns long, arranged in a row, and are primarily used for tissue fixation in biomedical applications. Microneedles can penetrate the surface of soft tissues inside and outside the body in a minimally invasive manner, causing minimal damage and pain. One of the main applications of microneedle patch systems is local drug delivery to reduce the side effects of systemic drug administration. When fixed to the target site, the microneedles create channels in the tissue for precise therapeutic drug delivery. Therefore, microneedle patch systems have advantages over other drug carriers such as hydrogels or nanoparticles.

Advantages of Transdermal Microneedle Patches

• Painless drug delivery: Since the length of the microneedles is short (usually between a few hundred microns and a few millimeters) and there are no pain nerves in the stratum corneum, transdermal microneedle patches will hardly cause pain during drug delivery.
• Highly efficient transdermal delivery: Microneedles can penetrate the stratum corneum of the skin to form micron-level channels, allowing drugs to directly enter the deep skin layer or subcutaneous tissue through these channels, thereby improving the transdermal efficiency of drugs.
• Good drug stability: The drugs in transdermal microneedle patches are usually wrapped inside the microneedles or attached to the surface of the microneedles, which can effectively protect the drugs from the influence of the external environment and maintain the stability and activity of the drugs.
• High patient acceptance: Transdermal microneedle patches are easy to use and simple to operate. Patients can use them by themselves under the guidance of doctors, which improves patient acceptance and compliance.

Our Transdermal Microneedle Patch Development Services

We can provide you with a variety of microneedle patch development services thanks to our transdermal microneedle patch development platform.

Fig.2 Our Transdermal Microneedle Patch Development (CD Formulation)

Transdermal Solid Microneedle Patch Development

Solid microneedles are usually made of metal or inorganic materials. Their main function is to puncture the epidermis and leave micron-level channels to help the subsequent drugs penetrate.

Transdermal Hollow Microneedle Patch Development

Hollow microneedles are similar to micron-level micro-injectors. After the needle tip pierces the skin, the drug in the needle cavity is released into the human body driven by the concentration gradient or external pressure.

Transdermal Coated Microneedle Patch Development

After the coated microneedle penetrates the skin, the drug attached to the surface of the microneedle can quickly dissolve in the skin and enter the human body.

Transdermal Dissolving Microneedle Patch Development

Soluble microneedles are mainly made of biodegradable polymer materials. After piercing the skin, the drug-loaded in them will be gradually released as the material degrades or swells.

Transdermal Hydrogel Microneedle Patch Development

After being inserted into the skin, the hydrogel microneedles quickly absorb interstitial fluid and swell to form continuous pores, through which the drugs penetrate the skin tissue.

Workflow for Custom Microneedle Patch Development

1. Design & Feasibility: Conceptualizing the microneedle patch design and conducting feasibility studies.
2. Prototype Development: Creating prototypes using advanced manufacturing processes.
3. Testing & Validation: Rigorous testing to validate performance, safety, and effectiveness.
4. Delivery & Support: Providing the final product along with comprehensive support and consultancy.

Advanced Microneedle Manufacturing Technology

Why Choose CD Formulation?

• We are committed to developing new biocompatible materials to improve the safety and effectiveness of microneedle patches.
• We customize the size, shape, and materials of microneedle patches according to customer needs and characteristics to achieve efficient and accurate transdermal drug delivery.
• By introducing advanced manufacturing technologies such as 3D printing and pull-up molding, we can get rid of the limitations of traditional template preparation methods and achieve flexible adjustment and high-precision manufacturing of microneedle structures.

Published Data

Transdermal microneedle patch is a new type of transdermal drug delivery device that improves the transdermal absorption efficiency of drugs. We have made important breakthroughs in microneedle design and manufacturing technology, such as unique advantages in microneedle size (length 150-1500 microns), material selection (silicon, titanium, stainless steel, polymers, etc.), and manufacturing process (such as etching of microstructures through resin or silicon). These technological breakthroughs enable MNPs to penetrate the stratum corneum of the skin more effectively while avoiding pain receptors, achieving painless drug delivery. If you have any needs, please feel free to contact us, and our colleagues will contact you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.