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Transdermal Patch Development

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Transdermal patches, also known as transdermal drug delivery systems (TDDS) or transdermal therapeutic systems (TTS), deliver medications directly into the bloodstream through the skin, achieving therapeutic blood concentrations for systemic treatments. Unlike topical systems that provide local effects, transdermal patches ensure consistent drug release for extended periods, making them one of the leading drug delivery methods after oral and injectable routes. CD Formulation excel in supporting the development of high-quality transdermal patch products to meet your research needs.

About Transdermal Patches

Fig.1 Components of a transdermal medical patch.Fig.1 Basic component of a transdermal medical patch. (Won Fen Wong, et al. 2023)

A transdermal patch is an innovative system that administers drugs through the skin by combining active pharmaceutical ingredients with a specialized matrix. Once applied, the drug penetrates the skin at a controlled rate to achieve either systemic or localized therapeutic effects. Our expert team meticulously designs and optimizes formulations by selecting suitable active ingredients, excipients, and utilizing cutting-edge preparation techniques to ensure maximum efficacy and quality.

Advantages of Transdermal Patches

Fig.2 Key advantages of transdermal patches.Fig.2 Advantages of Transdermal Patch (CD Formulation)

Cutting-Edge Transdermal Patch Technologies

We specialize in leveraging novel carriers to enhance drug penetration through the skin, improving drug solubility and stability.

  • Cubic Nanocarriers: Disrupt the stratum corneum's structure to improve drug fluidity and penetration.
  • Liposomes: These amphiphilic vesicles increase the transdermal delivery of poorly soluble or large-molecule drugs.
  • Microneedles: Create microchannels in the skin, allowing drugs to bypass the outer layers for more efficient absorption.

Our Transdermal Patch Development Services

We offer comprehensive formulation services for a wide range of transdermal patches, including but not limited to:

Our Workflow for Transdermal Patch Development

  1. Consultation: We begin by understanding your specific requirements and research goals.
  2. Formulation Development: Our experts carefully design and optimize formulations, selecting the most appropriate active ingredients, excipients, and drug carriers.
  3. Prototyping & Testing: We produce prototype patches and conduct extensive in vitro and in vivo testing to assess performance, stability, and safety.
  4. Optimization: Based on test results, we fine-tune formulations and technologies to ensure maximum efficacy.

Comprehensive Characterization and Analysis Platform

Characterization Platform Description
Standard Characterization Services
  • Drug content, uniformity, residual solvents, microbial limits, preservative and water content.
Advanced Characterization
  • In vitro transdermal tests, adhesion, stability testing, API crystallization, transdermal absorption enhancers, and packaging integrity.
Instrument Platform
  • High-performance liquid chromatography (HPLC)
  • Gas chromatography (GC)
  • UV-Vis spectrophotometry
  • Near-infrared spectrometry
  • Adhesion testing equipment

Why Choose CD Formulation?

  • Professional team: We have a professional R&D team that can deeply study the formulation design, preparation process, and transdermal mechanism of transdermal patches.
  • Innovation ability: We have strong innovation ability and can continuously explore new transdermal drug delivery technology, carrier materials, and penetration promotion methods to improve the transdermal absorption efficiency and stability of drugs.
  • Technology accumulation: We have accumulated rich technical experience in long-term research and practice, and can quickly respond to market demand and develop competitive transdermal patch products.

Published Data

Technology: Technology for transdermal patch development

Journal: Medicina

IF: 2.4

Published: 2023

Results: In this article, we review the existing literature on the design and usage of medical patches in transdermal drug delivery, with a focus on the recent advances in innovation and technology that led to the emergence of smart, dissolvable/biodegradable, and high-loading/release, as well as 3D-printed patches.

Transdermal patches have the advantages of easy use, stable blood drug concentration, and prolonged action time. We have mastered advanced transdermal drug delivery technologies, such as microneedle perforation, iontophoresis, ultrasonic iontophoresis, etc., which can significantly improve the skin permeability and bioavailability of drugs so that drugs can more effectively enter the body to play a role and develop high-quality transdermal patch products that meet clinical needs. If you have any needs, please feel free to contact us, and our colleagues will contact you within three working days.

References

  1. Won Fen Wong, Kuan Ping Ang, et al. Recent Advancement of Medical Patch for Transdermal Drug Delivery. Medicina. 2023, 59, 778.
How It Works
STEP 2
We'll email you to provide your quote and confirm order details if applicable.
STEP 3
Execute the project with real-time communication, and deliver the final report promptly.
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CD Formulation is a global force in transdermal delivery and manufacturing. We provide a wide range of contract development and manufacturing services that are specifically designed to cater to...

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