Nucleic Acid Transdermal Formulation Development

Nucleic acids have great potential for treating many diseases. Local administration of nucleic acids is particularly beneficial in treating skin diseases, as it avoids the challenges of systemic administration, such as enzyme degradation, systemic toxicity, and lack of skin targeting. CD Formulation is dedicated to the research and development of transdermal nucleic acid preparations, with a strong scientific research team and advanced production equipment.

About Nucleic Acid Transdermal Formulations

The introduction of nucleic acid transdermal formulations represents a pioneering approach to drug delivery, offering unique advantages and opportunities for therapeutic applications. This innovative method involves the delivery of nucleic acids (DNA or RNA) through the skin barrier, enabling targeted and sustained delivery to specific cells or tissues beneath the skin. Nucleic acid transdermal formulations hold promise for gene therapy, where functional genes can be delivered to correct genetic defects or modulate cellular processes. They can also serve as platforms for nucleic acid vaccines, delivering DNA or RNA vaccines through the skin to stimulate an immune response.

Advantages of Nucleic Acid Transdermal Formulations

The transdermal formulation of nucleic acids offers significant advantages, including patient comfort, compliance, controlled release, targeted delivery, and reduced side effects compared to traditional administration routes.

Fig.1 Advantages of Nucleic Acid Transdermal Formulation (CD Formulation)

What Can We Offer?

Skin Penetration and Barrier Overcoming

• Optimal Delivery System: Select or design a delivery system (e.g., nanoparticles, liposomes, microneedles) that can effectively penetrate the skin's barrier while protecting nucleic acids from degradation.
• Penetration Enhancers: Use appropriate penetration enhancers to facilitate the passage of nucleic acids through the stratum corneum and into target cells or tissues beneath the skin.

Stability and Protection of Nucleic Acids

• Stabilization: Nucleic acids are susceptible to degradation by nucleases and other factors. Incorporate stabilizers (e.g., sugars, polyols, proteins) and protective coatings (e.g., lipid bilayers) to maintain their integrity during formulation, storage, and delivery.

Targeting and Specificity

• Cellular Targeting: Design formulations that can target specific cell types or tissues beneath the skin, such as muscle cells for gene therapy or antigen-presenting cells for vaccination.
• Surface Modification: Utilize surface modifications or ligands on delivery vehicles to enhance targeting and cellular uptake of nucleic acids.

Explore Our Technology Platforms

Local delivery of nucleic acids is challenging. The outermost layer of the skin, the stratum corneum (SC), is a huge barrier for topical drugs to enter the skin. We use a variety of delivery methods to enhance the delivery of drugs into and through the skin.

Fig.2 Transport pathways into the skin. A: Intercellular pathway through lipid bilayers. B: Transcellular pathway through keratin-rich corneocytes. C: Shunt pathway through hair follicles and sweat ducts. (Michael Zakrewsky, et al. 2015)

• Liposomes or Nanoparticles: Encapsulating nucleic acids (DNA or RNA) within lipid-based vesicles or nanoparticles can protect them from degradation and facilitate their uptake through the skin.
• Electroporation: Applying electrical pulses to the skin temporarily disrupts cell membranes, allowing nucleic acids to enter cells more easily.
• Microneedles: These are tiny needles that painlessly penetrate the skin's outer layer, delivering nucleic acids directly to cells below.
• Chemical Enhancers: Certain chemicals can temporarily disrupt the skin barrier, enhancing the penetration of nucleic acids.

Why Choose CD Formulation?

• We have a strong research and development team and an innovative ability to continuously explore and optimize the formulation of nucleic acid transdermal formulations to improve the stability and bioavailability of drugs.
• Our precise formulation design capabilities enable us to design optimal formulations according to different drug properties and treatment needs.
• We have mastered advanced formulation processes, such as microneedle technology, iontophoresis technology, etc., which can significantly improve the skin permeability and bioavailability of nucleic acid drugs.

Published Data

The introduction of nucleic acid transdermal formulations represents a transformative advancement in drug delivery, offering new possibilities for precision medicine, gene therapy, and vaccination. Our company has rich experience in the field of nucleic acid drugs and can promote the research and development of transdermal nucleic acid formulations more efficiently, including drug design, synthesis, stability research and safety evaluation. If you have any needs, please feel free to contact us, and our colleagues will contact you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.