At CD Formulation, we are committed to leading the pioneering efforts in developing transformative oral nucleic acid solutions. Our team of skilled R&D specialists works diligently with state-of-the-art technology to significantly enhance the stability and absorption rates of these innovative formulations. Our goal is to deliver highly customized and effective development services that are meticulously tailored to the unique needs and expectations of our client base.

Why Develop Oral Nucleic Acid Formulations?

When taken orally, nucleic acid medications face challenges like stomach acidity, enzyme breakdown, and mucus barriers outside cells, along with obstacles like cellular membranes and entrapment within endosomes inside cells. To overcome these issues, strategies utilizing nanoparticles for oral delivery are developed. These systems provide protection against digestive degradation, enhance drug loading, allow flexibility for various nucleic acids, offer customizable sizes and shapes, target specific cells with modified compounds, and assist in crossing intestinal cell barriers.

Fig.1 Characteristics of oral formulation development. (CD Formulation)

Explore our Oral Nucleic Acid Formulation Development Services

Development of Oral Nucleic Acid Drug Formulation Carriers

Development of Oral Dosage Forms

• Development of Oral Solid Nucleic Acid Formulations

Our oral solid nucleic acid formulation development services involve the utilization of innovative technologies, focusing on optimizing drug stability and absorption efficiency. These offerings include designing formulations, testing stability, and optimizing production to maintain consistent product quality in diverse conditions. Furthermore, experimenting with various excipients and production techniques can significantly improve the bioavailability of solid nucleic acid formulations.

• Development of Oral Liquid Nucleic Acid Formulations

Our oral liquid nucleic acid formulation development services aim to provide highly precise and controlled nucleic acid delivery solutions. These services include formulation development of liquid dosage forms, selection of carrier systems, and regulation of solubility and viscosity to ensure stability and release characteristics of nucleic acids in the gastrointestinal tract. With modern analytical techniques and laboratory testing, the physicochemical stability and consistency of liquid formulations in different environments are ensured, thereby optimizing nucleic acid delivery efficiency.

Our Solutions for Oral Formulation Development

Our Workflow for Oral Nucleic Acid Formulation Development

Fig.2 Flow chart of oral nucleic acid formulation development. (CD Formulation)

• Molecular Design and Construction

Design appropriate nucleic acid molecular structures based on target functions, synthesize or clone them, ensuring they possess the required characteristics.

• Formulation Development

Design formulations, select suitable excipients, and optimize formulation stability and bioavailability to meet the requirements of oral administration.

• Process Optimization and Scale-Up Production

Optimize production processes, determine key parameters, conduct small-scale pilot production, and evaluate scalability to support large-scale production.

• Quality Assessment and Control

Develop detailed quality standards and conduct comprehensive testing of the physical, chemical, and biological properties to ensure the product meets quality requirements and industry standards.

Our Technology Platforms

Formulation Preparation Technologies

Characterization Technologies

• Spectral Analysis - Includes UV-visible spectrophotometry, used for identifying the chemical composition of nucleic acids and their carriers.
• DLS - Evaluates the size distribution and potential of carriers, which is crucial for understanding their stability and in vivo behavior.
• TGA and DSC - Used to evaluate the thermal stability and interaction of formulation components.

Our Advantages of Oral Nucleic Acid Formulation Development

• Utilizing various innovative formulation technologies, such as hot melt extrusion and microfluidics, can achieve more efficient and precise nucleic acid carrier construction.
• Novel coating and nanotechnologies help to enhance the stability of nucleic acid molecules and their bioavailability in vivo.
• Customizable development of suitable oral formulations according to different types of nucleic acids and application needs, adapting to diverse market demands.
• Experts covering chemistry, materials science, and biotechnology provide comprehensive support, ensuring the effectiveness and innovation of the formulation development process.

Publication Data

CD Formulation's professional team is fully prepared and ready to support your oral nucleic acid formulation development projects at any time, ensuring the smooth progress of your R&D endeavors. For additional information or to initiate a rewarding collaboration, please feel free to contact us and explore the possibilities together.