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Thermogravimetric Analysis (TGA) Platform for Nucleic Acid Drugs

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Thermogravimetric Analysis (TGA) instruments measure the amount and rate of change in sample mass as a function of temperature and time under controlled atmospheres. CD Formulation's TGA technology platform is utilized to characterize nucleic acid drugs that have experienced mass changes due to volatile loss, decomposition, or oxidation.

About Thermogravimetric Analysis for Nucleic Acid Drugs

Thermogravimetric analysis is a technique used to measure changes in sample weight as a function of temperature or time within a controlled thermal environment. Variations in sample weight may result from changes in chemical or physical properties and can be detected with precision down to fractions of a microgram. TGA is effective for studying the thermal stability of solid or liquid materials under elevated temperature conditions in either inert or oxidizing atmospheres. Additionally, TGA can be conducted at a constant temperature to evaluate the thermal stability of a material over a specified duration.

Fig.1 About thermogravimetric analysis for nucleic acid drugs Fig.1 TGA curves of DNA samples. (Suryaprabha T, et al., 2020)

Types of Our Thermogravimetric Analysis Technology Platforms

Coupling technologies that integrate thermogravimetric analysis with other instruments can provide deeper insights and enhance your research. CD Formulation's thermal analysis technology platforms offer a range of options to accommodate various experimental requirements.

Platforms	Descriptions
High-Resolution TGA Platform	High-resolution thermogravimetric analysis (TGA) is a technique used to measure the mass change of a material during temperature variations at a highly precise scale.
TGA/MS Platform	Thermogravimetric Analysis/Mass Spectrometry (TGA/MS) enables the comprehensive analysis and characterization of gaseous molecules released during the pyrolysis of a sample. By integrating TGA with Mass Spectrometry, accurate molecular weight information and distribution can be obtained.
TGA/FTIRPlatform	Thermogravimetric Analysis/Fourier Transform Infrared Spectroscopy (TGA/FTIR) employs an infrared spectrometer to analyze the gases released during the pyrolysis of a sample.
STA Platform	Simultaneous Thermal Analysis (STA) integrates TGA and Differential Thermal Analysis (DTA) into a single instrument, enabling concurrent measurements of a sample's mass change alongside its heat absorption and release.

Factors Affecting TGA Results

Excessive sample size results in slower heat transfer and volatilization of volatile compounds, leading to closely spaced weight loss transitions. Therefore, the sample size should be minimized while remaining within the permissible sensitivity range.
The fineness of the sample and the density of the filling significantly affect heat transfer and the volatilization of volatile compounds. Generally, the sample should be finely ground and uniform, and it should be packed into a consistent, thin layer to ensure optimal tightness.
The gas surrounding the sample expands as the temperature rises, resulting in a decrease in specific gravity. Consequently, the TGA value of the sample increases.
Volatiles released during the decomposition of substances may condense on the cooler areas of the weighing dish, thereby impacting the measurement of weight loss.
If the heating rate is too rapid, the TGA curve will shift to higher temperatures; conversely, if the rate is too slow, the experimental efficiency will decrease.

Highlights of Thermogravimetric Analysis Platform for Nucleic Acid Drugs

Thermogravimetric analysis requires small sample volumes, which is particularly important for costly or rare nucleic acid drug samples.
Minimal sample preparation is required to analyze both solids and liquids, making experiments easy and efficient to conduct.
TGA technology can analyze samples both qualitatively and quantitatively, offering detailed data on changes in material composition and quality.
High-resolution TGA has the distinct advantage of separating overlapping thermal mass loss events, thereby providing a clearer understanding of the thermal stability of materials.

Our Analytical Characterization Services

CD Formulation's TGA technology platform offers valuable insights for material selection, identification of reactivity, quantification of composition or impurity content, and analysis of moisture and volatile content.

Moisture Content Determination for Nucleic Acid Drugs

Thermal analysis techniques can determine the amounts of adsorbed water, bound water, and water of crystallization in the drug, as well as assess the uniform dispersion of the drug preparation.

Stability Analysis for Nucleic Acid Drugs

Important information necessary for studying drug storage and transportation conditions can be analyzed through thermal analysis kinetics, providing a foundational reference for drug potency and related factors.

Publication Data

Technology: TGA technology platform for analyzing ionic polymers

Journal: Molecules

IF: 4.2

Published: 2023

Results:

The authors investigated how the carboxylic acid functional groups of ionic polymers influence the compatibility of blends at the interface of the two materials and how this compatibility affects their properties. Two series of blends, TPS/EMAA and TPS/EMAA-54Na, were produced using an in-house mixer, with the composition of TPS varying from 5 to 90 wt%. Thermogravimetric analysis revealed two significant weight losses, indicating that TPS and the two copolymers are primarily immiscible. At the mesoscale level, scanning electron microscopy corroborated the findings of the thermogravimetric analysis, demonstrating a two-phase domain morphology with a phase inversion occurring at approximately 80 wt% TPS, as well as differing surface appearance evolution between the two series.

Fig.2 TGA technology platform for analyzing ionic polymers Fig.2 TG and dTG curves. (Dony P, et al., 2023)

CD Formulation offers an advanced thermogravimetric analysis platform that uses state-of-the-art instruments to precisely study the thermal stability and decomposition behavior of samples. We can monitor and analyze the quality changes of nucleic acid drugs in real-time under heating conditions. Contact us, and we will provide professional solutions for your project.

References

Suryaprabha T, Sethuraman M G. Fabrication of a superhydrophobic and flame-retardant cotton fabric using a DNA-based coating. J. Mater. Sci. 2020, 55: 11959-11969.
Dony P, Berzin F. Thermogravimetric, Morphological and Infrared Analysis of Blends Involving Thermoplastic Starch and Poly (ethylene-co-methacrylic acid) and Its Ionomer Form. Molecules. 2023, 28(11): 4519.

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