CD Formulation boasts extensive project experience in the development of transdermal drug formulations, equipped with relevant transdermal and analytical instruments to offer professional and efficient services in nucleic acid drug development, modification, and analysis.

About Transdermal Nucleic Acid Formulation Development

Transdermal Drug Delivery Systems (TDDS) represent a unique route of administration that employs skin as a conduit for drug absorption, allowing direct entry into the bloodstream for disease prevention or treatment. TDDS is recognized for its safety and good tolerance, combining the dosage accuracy and simplicity of oral formulations with the potential to deliver therapeutics non-metabolically to plasma associated with parenteral routes. Transdermal formulations include patches, ointments, plasters, paints, and aerosols.

Unique Advantages of Transdermal Nucleic Acid Formulation Development

• Drug absorption is unaffected by gastrointestinal pH, food, or transit times.
• Local application allows direct action on target sites, enhancing efficacy.
• It circumvents hepatic first-pass metabolism and gastrointestinal interference.
• Maintains a consistent plasma drug concentration over extended periods, preventing peak-trough fluctuations and reducing side effects.
• Extends the duration of effective action, decreases dosing frequency, and improves compliance.

Explore Our Transdermal Nucleic Acid Formulation Development Services

Development of Various Types of Transdermal Drug Formulations

Development of Transdermal Penetration Enhancers

CD Formulation can create transdermal penetration enhancers customized to meet client requirements. We select various types of enhancers based on specific applications and develop appropriate formulations.

The typical classifications of these enhancers are outlined below:

• Surfactants
• Organic Solvents
• Lauryl Pyrrolidone and its Analogs
• Organic Acids
• Stratum Corneum Moisturizers and Softeners
• Terpenes

Quality Control in Transdermal Nucleic Acid Formulation Development

Stability Assessments

Perform both prolonged and accelerated stability evaluations in varying environmental conditions to ensure formulation components remain intact and avoid degradation throughout storage and use.

Physicochemical Evaluation

Precisely assess formulation attributes like pH, electrical conductivity, and viscosity to confirm its uniformity and dependability across different conditions.

Microbial Limit Examination

Verify that the transdermal formulation remains microorganism-free during its production and storage phases, achieving sterility or minimal microbial presence as per regulatory standards.

Measurement of Nucleic Acid Drug Release

In vitro evaluation focuses on determining content, release rate, transdermal permeability, and adhesion properties. In vivo evaluation involves assessing bioavailability and conducting studies on in vitro-in vivo correlation.

Transdermal Adhesive Strength Testing

Quick-stick force refers to a TDDS (transdermal drug delivery system) system's ability to adhere to the skin with minimal pressure. Various methods include:

• Thumb test
• Rolling ball test
• Peel adhesion test

Cohesive Strength Assessment

Cohesion relates to the shear strength of pressure-sensitive adhesives (PSA) and is measured by their ability to resist creep under shear stress, known as holding power. Adequate cohesion ensures that the TDDS system remains in place during use and leaves no residue upon removal.

Our Workflow for Transdermal Nucleic Acid Formulation Development

Fig.1 Flow chart of transdermal nucleic acid formulation development. (CD Formulation)

• Design of Transdermal Delivery Formulations

Combining customer needs with the characteristics of nucleic acid drugs, we design appropriate types of transdermal delivery formulations (such as reservoir type or matrix type), determine suitable transdermal absorption enhancers, and develop preliminary formulation schemes.

• Preliminary Testing of Transdermal Delivery Formulations

We conduct initial preparation of transdermal delivery formulations, testing for drug content and absorption rate, and examine the formulation's stability and safety under various conditions.

• Formulation Optimization and Pilot Scale-up

Based on preliminary test results, we optimize the formulation and release system, conduct pilot scale-up tests to verify the feasibility and consistency of the formulation in mass production.

• Quality Control and Assessment

Conduct comprehensive in vitro evaluations, including release rate, permeability, and adhesion performance tests, and use in vivo evaluation methods to study bioavailability and consistency.

• Process Validation and Mass Production

After passing all quality control tests, we perform process validation and prepare for mass production, ensuring the controllability and consistency of all quality indicators during the production process.

Our Technology Platforms

Nucleic Acid Formulation Preparation Technology

Our platform covers the preparation process of nucleic acid drugs, involving the selection of suitable materials and processes to ensure the stability and effectiveness of formulation development.

Analytical Technology Platforms

Our platform focuses on the application of analytical technology, using advanced tools and methods to evaluate the quality and performance of nucleic acid formulations, ensuring product reliability and consistency.

Our Advantages of Transdermal Nucleic Acid Formulation Development Services

• Our transdermal formulation services enhance delivery efficiency by optimizing how therapeutic agents are absorbed through the skin.
• We enhance nucleic acid stability with advanced techniques, ensuring compound integrity and effectiveness.
• Our services create formulations for consistent release, reducing dosing frequency and improving patient adherence.
• By targeting local delivery, we minimize systemic exposure and significantly reduce potential side effects.

Publication Data

At CD Formulation, we apply our expertise to craft sophisticated transdermal nucleic acid formulations, precisely tailored to your specific project requirements. Our team is poised to help you achieve exceptional delivery results. Get in touch with us to explore how we can aid your advancements in transdermal technologies.