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Natural Polysaccharide Drug Delivery System Platforms

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Natural polysaccharide drug delivery platforms employ natural polysaccharides as drug carriers specifically designed to enhance drug stability and targeting. CD Formulation's natural polysaccharide drug delivery platforms provide a versatile and safe solution for drug design and delivery, leveraging the unique physicochemical properties and biocompatibility of polysaccharides, which include a diverse range of sources and low toxicity.

About Natural Polysaccharide Drug Delivery System

Polysaccharides are among the most attractive and promising biomaterials for pharmaceuticals due to their excellent biocompatibility, biodegradability, and non-toxicity. They interact with nucleic acids through electrostatic and hydrophilic interactions, forming small, tightly packed structures. Nucleic acids are encapsulated within a polysaccharide matrix and shielded by polysaccharide chains, which sterically hinder access to nucleolytic enzymes. Natural polysaccharide drug delivery systems (P-DDS) offer significant advantages over synthetic polymers in terms of biocompatibility and degradability. The byproducts of enzymatic and acid degradation are harmless to the human body, facilitating the prolonged circulation of the carrier in the bloodstream.

Fig.1 Advantages of natural polysaccharide platforms Fig.1 The design strategies of polysaccharide-based drug delivery systems (DDSs). (Sun Y, et al., 2020)

Types of Polysaccharide Carriers

Polysaccharide Carriers	Descriptions
Starch	Starch can bind nucleic acid drugs through both non-covalent and covalent bonds. Starch that has been modified by quaternization into positively charged polysaccharides can bind nucleic acid drugs via electrostatic interactions.
Hyaluronic Acid	Hyaluronic acid and its derivatives serve as effective drug carriers, facilitating drug thickening, sustained release, transdermal absorption, and enhanced drug targeting. The chemical modification sites of hyaluronic acid include carboxyl and N-acetyl groups, in addition to hydroxyl groups. Furthermore, hyaluronic acid-grafted derivatives have been developed for LYVE-1-mediated delivery of siRNA to targeted cells.
Cellulose	HPMC is widely utilized as a drug delivery material for several reasons: it is water-soluble, does not interfere with drug availability or tablet disintegration rates, and exhibits good stability.
Dextrose	The combined advantages of hydrophilicity, biocompatibility, biodegradability and ease of chemical derivatization of dextrose as a plasma volume expander to enhance peripheral blood flow or as a rheological excipient in artificial tears are all related to its suitability as a drug delivery biopolymer.
Chitosan	Chitosan is a cationic polymer that can deliver DNA and RNA molecules through electrostatic attraction and coupling.

Types of Natural Polysaccharide Drug Delivery Platforms

Polysaccharide Nanoparticle Platform

Polysaccharides are primarily synthesized into nanoparticles through methods such as polyelectrolyte complexation (PEC), self-assembly, covalent cross-linking, and ionic cross-linking. As drug delivery systems, nanoparticles can encapsulate drugs or biomolecules within their internal structures or adsorb them onto their external surfaces.

Polysaccharide Nanomicelles Platform

Hydrophilic charged macromolecules, such as nucleic acids, are utilized as micellar payloads. These macromolecules are incorporated into the micellar nuclei through electrostatic interactions, resulting in the formation of a nucleus composed of polyionic complexes.

Polysaccharide Nanogel Platform

Natural polysaccharide nanogels, such as hyaluronic acid, cellulose, and dextrose, can be utilized for the controlled delivery of nucleic acid drugs, primarily due to their favorable drug loading capacity.

Natural Polysaccharide Modification Platform

Our natural polysaccharide modification platform focuses on the structural modification and functionalization of natural polysaccharides using various chemical, physical, and biotechnological methods. The goal is to enhance their solubility, biocompatibility, and drug-binding capacity, thereby increasing their potential for drug delivery, tissue engineering, and biomedical applications.

Sulfation Modification	Aldoxylation Modification
Sulfation modification leads to significant alterations in the electrostatic repulsion and spatial resistance of the polysaccharide, enhances the flexibility of the polysaccharide chain, and improves its aqueous solubility.	The polysaccharide polyaldehyde structure can be crosslinked with cell adhesion functional groups such as cholesterol (Chol) or spermine (SP) to create hydrogel carriers, thereby enhancing the cellular uptake of P-DDS.
Carboxymethylation Modification	Quaternization Modification
Carboxymethylated polysaccharides are widely utilized in drug delivery systems due to their excellent controlled release properties.	Quaternized modified polysaccharides serve as drug permeation enhancers, facilitating the release of nucleic acid drugs within the body.

Highlights of Natural Polysaccharide Drug Delivery Platforms

The platform can be customized with a variety of natural polysaccharides, such as chitosan, alginate, and hyaluronic acid, to facilitate different types of drug delivery.
By optimizing the physical and chemical properties of polysaccharides, the solubility and stability of drugs are enhanced, thereby ensuring more efficient delivery.
The selected natural polysaccharide materials exhibit excellent biocompatibility, which reduces toxic side effects and enhances patient acceptance.
The platform offers comprehensive process customization services, ranging from initial research and development to scaled-up production, in order to meet the unique requirements of our customers.

Custom Nucleic Acid Formulation Carrier Services

CD Formulation's natural polysaccharide carrier customization service is designed to provide customers with biomaterials tailored to their specific needs. We focus on designing and optimizing polysaccharide vectors using advanced technology to ensure their efficacy and safety in various applications.

Natural Polysaccharide Development Services

In our natural polysaccharide carrier customization services, our professional team performs a needs analysis based on the client's requirements and designs innovative vector structures that leverage the inherent benefits of polysaccharides, including biocompatibility and low immunogenicity.

Publication Data

Technology: Natural polysaccharides platform for drug delivery

Journal: Antioxidants

IF: 5.014

Published: 2022

Results:

Many chronic diseases, such as Alzheimer's disease, diabetes, and cardiovascular diseases, are closely related to oxidative stress caused by excess reactive oxygen species (ROS) in the body. As a biomolecule with good biocompatibility, natural polysaccharides have been widely used in biomedicine and medicine due to their excellent antioxidant properties. The antioxidant mechanisms of natural polysaccharides mainly include modulation of signaling pathways, activation of enzymes and scavenging of free radicals. We will continue to explore the antioxidant activities of natural polysaccharides and their derivatives. Also, the authors summarize their applications in the fields of pharmaceuticals/drug delivery, tissue engineering and antimicrobial food additives/packaging materials.

Fig.2 The application of natural polysaccharides. (Bai L, et al., 2022)

CD Formulation's natural polysaccharide drug delivery platform is committed to modifying and reformulating natural polysaccharides using advanced science and technology to enhance their biocompatibility and delivery efficiency. If you require technical support for your project, please do not hesitate to contact us for customized drug delivery system solutions.

References

Sun Y, Jing X, Ma X, et al. Versatile types of polysaccharide-based drug delivery systems: From strategic design to cancer therapy. Int. J. Mol. Sci. 2020, 21(23): 9159.
Bai L, Xu D, Zhou Y M, et al. Antioxidant activities of natural polysaccharides and their derivatives for biomedical and medicinal applications. Antioxidants. 2022, 11(12): 2491.

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