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Virus-like Particle Drug Delivery Platforms

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CD Formulation's VLP platform leverages exceptional preparation techniques to achieve significant competitive advantages. It excels in the purification process, particle depolymerization and reassembly, as well as formulation stability of VLPs. Additionally, it meets high standards in advanced structural analysis and maintains strict control over particle uniformity and regulation.

Applications of Virus-like Particle Platforms

Applications	Descriptions
Vaccine Development	VLPs show notable promise in the vaccine domain. Since they lack the genetic material of viruses, they offer a highly safe alternative to traditional vaccines, significantly reducing potential side-effect risks.
Drug Delivery Systems	VLPs can be engineered to precisely guide drugs to specific cells, improving effective delivery while minimizing impact on non-target areas. By attaching specific ligands to VLPs, targeted delivery of chemotherapy drugs is achievable, allowing them to more effectively target cells while minimizing interference with other regions.

Types of VLP Drug Delivery Platforms

Non-enveloped VLPs Platform

This platform uses nanoparticles self-assembled only from capsid proteins, making it relatively simple in structure and suitable for applications with minimal protein shell requirements. Due to the absence of a lipid envelope, they are stable in purification and manufacturing processes, making them widely used for basic research and certain vaccine developments.

Enveloped VLPs Platform

This platform produces VLPs with lipid envelopes from host cells, displaying specific antigenic spike proteins on the surface. This makes them ideal biomimetic tools for vaccine development and targeted drug delivery through surface antigen presentation.

Methods for Loading Nucleic Acid Drugs into VLPs

Items	Descriptions
Exogenous Protein Fusion	We achieve precise loading by fusing VLP structural proteins with exogenous proteins or peptides, directly integrating protein cargo into VLPs.
De Novo Nucleic Acid Packaging	Under certain conditions, VLP subunit proteins mix with nucleic acids of specific sequences or structural characteristics, attracting capsid proteins to enclose them within VLPs.
Osmotic Shock	In low ionic strength buffers, the distance between subunits on the VLP surface increases, allowing nucleic acid molecules to be introduced into VLPs through physical interactions.
Electrostatic Adsorption	Using positively charged compounds like polyethyleneimine (PEI), negatively charged nucleic acids are efficiently loaded onto VLPs through electrostatic interactions.
Depolymerization and Reassembly	Chemical treatments with reagents like urea/NaCl or DTT/CaCl₂ disassemble and reassemble VLPs to accommodate cargo molecules such as nucleic acids.
Chemical Conjugation	Chemical or biochemical means form strong covalent bonds between VLPs and cargo to achieve precise payload loading.

Highlights of Virus-like Particle Drug Delivery Platform

Our platform uses advanced procedures to ensure precise control over particle size and structure, thus improving delivery efficiency.
It is flexibly designed to adjust particle composition and surface characteristics for precise targeting based on varying needs.
Without genetic components, the platform demonstrates high safety, eliminating infection risk and offering wide applicability.
Its multifunctionality makes it suitable for vaccine development and various drug delivery strategies.
Our platform's technology complies with international standards, supporting innovative applications' global deployment and promotion.

Custom Nucleic Acid Formulation Carrier Services

CD Formulation's platform services encompass the full process from nanoparticle design and optimization to large-scale production, providing tailored solutions. Our platform uses advanced technology for precise particle assembly and characteristic regulation, ensuring stability and functionality.

Virus-like Particles Development Services

Our carrier customization services focus on meeting clients' unique needs, combining cutting-edge biotechnology with deep expertise to optimize the assembly and functionalization of VLPs.

Publication Data

Technology: Inhalation formulation development utilizing a platform of virus-like particles (VLPs)

Journal: Allergo journal international

IF: 2.42

Published: 2018

Results:

Literature reviews indicate that VLPs deliver positive results, occasionally even in the absence of specific allergens. However, extensive investigations are essential to fully understand their potential and ensure their long-term compatibility and use.

Fig.1 Immune Mechanisms of Vaccines Utilizing Virus-like Particles (VLPs) Fig.1 Immunological mechanisms of VLP-based vaccines. (Klimek L, et al., 2018)

CD Formulation's VLP drug delivery platform delivers highly precise and effective drug delivery solutions, supporting your research and development projects. Our experienced team is ready to provide customized services tailored to your needs. Whether you are seeking collaboration or professional support, please feel free to get in touch with us.

References

Klimek L, Kündig T, Kramer M F, et al. Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases. Allergo J. Int. 2018, 27: 245-255.

How It Works

STEP 1

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STEP 2

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STEP 3

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