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Bio-MOFs Drug Delivery Platforms

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At CD Formulation, we specialize in developing Bio-MOFs technology platforms, offering innovative solutions for nucleic acid delivery. By integrating material science with nanotechnology, our Bio-MOFs platform supports the design and synthesis of biocompatible metal-organic frameworks aimed at optimizing nucleic acid payloads and delivery efficiency. We offer various customizable carrier options to flexibly meet diverse nucleic acid delivery requirements.

Bio-MOFs Preparation Technologies

Technologies	Descriptions
Solvothermal Method	Under solvothermal conditions, reactants undergo reaction under high temperature and pressure to form Bio-MOFs with highly ordered channel structures.
Room Temperature Solution Method	Suitable for synthesizing MOFs that form under conventional conditions, usually through pH adjustment for structure self-assembly.
Microwave-assisted Synthesis Method	Microwave synthesis provides high energy in a short time to accelerate Bio-MOFs formation, reducing reaction time and enhancing crystallinity.
Electrochemical Synthesis Method	Metal ions are deposited electrochemically then combined with organic linkers to form Bio-MOFs, offering high controllability.
Template-assisted Method	Utilizes templates to guide formation of MOF materials, achieving special channel structures followed by removal of the template through physical or chemical methods.

Types of Bio-MOFs Platforms

Multi-functional Bio-MOFs Platform

This platform incorporates various functional groups into the framework to effectively load and protect nucleic acid molecules. Functional groups may include cleavable chains, fluorescent tags, or biocompatible polymers, securely attaching nucleic acids to the framework surface via chemical bonds or electrostatic interactions, enhancing transport stability and efficiency.

Microenvironment Responsive Platform

Designed to exploit the sensitivity of Bio-MOFs to microenvironment changes, this platform responds swiftly under specific physiological conditions such as low pH or reductive environments. This response triggers disassembly of the framework, releasing the embedded nucleic acids, enabling controllable release strategies to enhance delivery precision.

Hollow Nanosphere Platform

With its unique cavity structure, the Hollow Nanospheres platform provides space for nucleic acid macromolecule encapsulation, allowing stable existence and content protection in vivo. By adjusting shell thickness and pore size in this design, Bio-MOFs enhance delivery precision and efficiency.

Our Solutions of Bio-MOFs Platforms

Items	Descriptions
Efficient Loading	Bio-MOFs are designed with nanoporous structures that maximize capacity for nucleic acid molecules on a microscopic scale. By optimizing porosity and pore size, Bio-MOFs ensure maximum drug load without enlarging carrier size.
Controlled Release	Our platform supports precise design adjustments to control release rates. Modulating metal nodes and organic linker combinations allows different release profiles, ensuring nucleic acids are effective at desired time points.
Targeted Delivery	Bio-MOFs can be chemically modified to incorporate specific recognition groups for interaction with biological targets. This enhances carrier selectivity, enabling nucleic acids to preferentially reach intended areas.

Highlights of Bio-MOFs Platforms

Our platform allows for the selection and synthesis of various Bio-MOFs structures, with tunable pore size and surface features to meet the specific needs of different nucleic acids and delivery mechanisms.
Through optimized structural design, Bio-MOFs efficiently load and stabilize nucleic acids, preventing degradation from external environments, and thus providing robust molecular carriers.
The platform supports chemical modification of Bio-MOFs for enhanced target recognition capability, increasing the precision and efficiency of nucleic acid transfer.
Material selection is rigorously screened to ensure excellent biocompatibility, minimizing potential side effects while maintaining functional effectiveness.
Through comprehensive structural and compositional analysis, our platform provides detailed characteristic reports for Bio-MOFs and their nucleic acid loads, ensuring batch stability and quality control.

Custom Nucleic Acid Formulation Carrier Services

CD Formulation's Bio-MOFs platform focuses on providing comprehensive carrier development services to meet varied nucleic acid delivery needs. Our team is dedicated to crafting custom solutions to support complex research goals, driving advancements at the frontier of biotechnology.

Bio-MOFs Development Services

By combining cutting-edge material science and nanotechnology, we design and construct Bio-MOFs carriers with excellent structural properties. Their unique porous architecture and adjustable surface chemistry ensure efficient drug loading capabilities and precise targeted delivery functions.

Publication Data

Technology: Development of drug delivery systems (DDSs) utilizing the Bio-MOFs platform

Journal: Nanomaterials

IF: 5.076

Published: 2023

Results:

The efficacy of drug delivery systems (DDS) relies on their biocompatibility, inherently high specific surface area, substantial interconnecting porosity, and chemical functionality. Recent advances in metal-organic framework (MOF) nanostructures have facilitated the realization of these desirable properties. The distinguishing features of MOFs include their exceptional surface area, interconnected porosity, and versatile chemical functionality, which have led to numerous methods for drug loading within their hierarchical structures. MOFs meet the biocompatibility requirements and are currently regarded as highly effective DDSs for the treatment of a wide range of diseases. This review aims to provide a comprehensive overview of the biocompatibility of DDSs based on chemically functionalized MOF nanostructures for cancer treatment. Additionally, it presents the development and application of these DDSs in cancer therapy. A brief overview of the structure, synthesis, and mode of action of MOF-DDSs is included in this paper.

Fig.1 A variety of MOF structures are available for formulating drug delivery systems. Fig.1 Various types of MOF structures for drug delivery formulations. (Elmehrath S, et al., 2023)

If you are interested in our Bio-MOFs technology platform or want to learn more about building customized nucleic acid delivery systems, feel free to contact us. We look forward to collaborating with you to unlock the potential of Bio-MOFs in nucleic acid delivery, helping you achieve your research objectives.

References

Elmehrath S, Nguyen H L, Karam S M, et al. BioMOF-based anti-cancer drug delivery systems. Nanomaterials, 2023, 13(5): 953.

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