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Therapeutic Peptide Synthesis and Production

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Many peptide drugs are developed by chemically modifying natural molecules or by artificial synthesis. CD Formulation provides reliable custom peptide synthesis services, from crude peptides to advanced peptides, we provide unparalleled service flexibility to meet your personalized needs.

About Peptide Synthesis?

Peptide pharmacology unfurls a realm teeming with intricacies, where chains of amino acids—those fundamental building blocks of life—forge connections via elusive peptide bonds. These molecular marvels assume myriad roles. They are not merely passive entities but dynamic players acting as messengers of vital signals, catalysts sparking transformative reactions, and modulators steering the course of countless biological symphonies. Indeed, the arena of peptide synthesis is rapidly morphing into a veritable epicenter of innovation and discovery. As researchers navigate this complex landscape, the potential of peptides continues to unfold, promising breakthroughs that could revolutionize therapeutic strategies and redefine our understanding of biology itself.

Fig. 1 Peptide synthesis and production. Fig. 1 Schematic representation of peptide synthesis and production. (Chandrudu S, et al., 2013)

Explore Our Custom Therapeutic Peptide Synthesis and Production Services

At CD Formulation, we wield an array of techniques that is as eclectic as it is advanced to ensure that the peptides we forge possess not only superior functional properties but also unparalleled production efficiency.

Our adept team is primed to tackle a multitude of complex peptide projects, including but not limited to:

Custom Specialty Peptide Synthesis
Custom Modified Peptide Synthesis
Custom Labeled & Conjugated Peptide Synthesis
Therapeutic Peptide Library
Therapeutic Peptide Array
Large Scale Therapeutic Peptide Synthesis
Neoantigen Peptide Production
Recombinant Peptide

Our Widely Used Peptide Synthesis Methods

Chemical Synthesis	Biosynthesis	Semisynthesis
Solid-phase peptide synthesis (SPPS). Liquid phase peptide synthesis (LPPS). Microwave-assisted solid-phase synthesis (MW-SPPS). Chemo enzymatic peptide synthesis (CEPS).	Enzyme decomposition synthesis method. Recombinant expression method (bacterial system, yeast system, and mammalian or insect cell line). Genetic engineering method.	The peptide fragments are joined together by chemical or enzymatic ligation.

SPPS and LPPS are our preferred chemical methods for producing linear peptides.

When your project is a large peptide with a complex secondary or tertiary structure, we will choose to produce it by recombinant expression. However, this technology is limited to natural amino acids produced and processed by the host organism. Therefore, when you need to produce peptides with complex structures and unnatural amino acids, we will choose semisynthetic methods.

What Do We Ultimately Deliver?

Delivery Specifications	Description
Peptide Synthesis Method	Fmoc solid phase synthesis (standard). Liquid phase synthesis (upon request). Recombinant expression (upon request). GMP peptide synthesis (upon request).
Quantity	1 mg - 2 kg
Purity	Crude to >98%. TFA removal upon request.
Peptide Sequence	Lyophilized peptides. QC report.
Standard Quality Inspection Report	Amino acid sequence. Purity information. Quantity information. Modification and conjugation information. MS and HPLC profiles (except crude and desalted peptides).
Additional Analysis	Solubility test. Net peptide content analysis (N%). Qualitative amino acid analysis (AAA). Water content analysis. Solvent residues. Endotoxin (<1EU/MG).
2-3 Weeks Delivery

Peptide Manufacturing & Analytical Services

In addition to peptide synthesis capabilities, we combine flexible GMP manufacturing facilities with cutting-edge peptide analytical knowledge to provide a full range of quality control testing services to accelerate the commercialization of your products, including:

Peptide identification (ESI-MS).
Peptide Molecular weight determination.
Peptide sequencing.
Peptide quantification/peptide content determination.
Peptide purity and impurity analysis (HPLC/UV).
Amino acid sequence.
Amino acid composition determination.
Net peptide content.

Enantiomeric purity testing (GC/MS; LC).
Residual counterion testing (e.g. TFA).
Elemental analysis.
Residual solvent testing.
Water content testing (GC or KF).
Peptide solubility testing.
Peptide stability testing.

Optical rotation determination.
Bioburden testing(TAMC/TYMC).
Bacterial endotoxin testing.
Sterility testing.
Cytotoxicity testing.
Process/product related impurity testing.
Other pharmacopoeia testing.

Publication

Published Data

Technology: Automated Fmoc-Based Synthesis

Journal: Chem Sci.

IF: 7.6

Published: 2016

Results:

The authors designed and improved a straightforward and flexible device for making peptide thioester substitutes. They effectively used it to synthesize two natural long peptides that are rich in cysteine. This apparatus is a novel C-terminal N -(2-hydroxybenzyl)cysteine thioesterification apparatus based on amide to thioester rearrangement, and the resulting peptide cryptothioesters can be directly used for NCL reactions with fast N → S transfer kinetics at neutral pH. In addition, the synthetic apparatus is fully automated and does not require any post-synthetic steps before native chemical ligation (NCL).

Fig. 2 In situ synthesis of peptide thioesters. Fig. 2 N → S shift-based in situ synthesis of peptide thioesters for NCL. (Terrier VP, et al., 2016)

CD Formulation has extensive experience in custom therapeutic peptide synthesis and production. Each synthesis step is subject to our strict quality control. Please don't hesitate to contact us if you are interested in our services. We look forward to cooperating with you.

References

Chandrudu S, Simerska P, Toth I. Chemical methods for peptide and protein production. Molecules. 2013 Apr 12;18(4):4373-88.
Terrier VP, Adihou H, Arnould M, et al. A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters. Chem Sci. 2016 Jan 1;7(1):339-345.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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